Effect of local and parenteral immunization on implantation of Actinomyces viscosus T6 in rats

Olsson, J.; Hsu, Shin; Kingman, Albert; Cole, Michael F.

doi:10.1128/iai.47.1.301-305.1985

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…These data demonstrate that effective protection against colonization of tooth surfaces by immunization correlates with elevated levels of fimbria-specific IgA and IgG in serum and saliva. These results are also consistent with the recent report by Olsson and co-workers (26), who showed that rats immunized with A. viscosus whole cells were also protected against initial infection.…”

Section: Mutanssupporting

confidence: 93%

Modulation of Actinomyces viscosus colonization of mouse teeth in vivo by immunization with fimbrial adhesins

Crawford¹,

Clark²

1986

Infect Immun

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Section: Mutanssupporting

confidence: 93%

Modulation of Actinomyces viscosus colonization of mouse teeth in vivo by immunization with fimbrial adhesins

Crawford¹,

Clark²

1986

Infect Immun

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“…Crawford et al (96) found that high salivary IgA and IgG responses limited the colonization of A. naeslundii and the development of periodontal bone loss but the immunization with A. naeslundii genospecies 2 increased periodontal loss. In another study, salivary antibodies were found to be capable of reducing the initial implantation of A. naeslundii genospecies 2 but had limited capability in suppressing the establishment of this organism (356). The injection of whole cells or fimbrial components of Porphyromonas gingivalis in the vicinity of submaxillary glands of germfree rats led to increased levels of salivary antibodies and protected against periodontal destruction (131,132).…”

Section: Active Immunization Against Oral Diseasesmentioning

confidence: 97%

“…A few investigations have studied the effects of stimulation of salivary IgA antibodies on the progress of periodontal bone loss in rodents. Germfree rats were immunized in the salivary gland region with whole cells of Actinomyces naeslundii genospecies 2 or A. naeslundii and then inoculated orally with the live homologous organism (96,356). Crawford et al (96) found that high salivary IgA and IgG responses limited the colonization of A. naeslundii and the development of periodontal bone loss but the immunization with A. naeslundii genospecies 2 increased periodontal loss.…”

Section: Active Immunization Against Oral Diseasesmentioning

confidence: 99%

Oral Microbial Ecology and the Role of Salivary Immunoglobulin A

Marcotte¹,

Lavoie

1998

Microbiol Mol Biol Rev

430

294

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SUMMARY In the oral cavity, indigenous bacteria are often associated with two major oral diseases, caries and periodontal diseases. These diseases seem to appear following an inbalance in the oral resident microbiota, leading to the emergence of potentially pathogenic bacteria. To define the process involved in caries and periodontal diseases, it is necessary to understand the ecology of the oral cavity and to identify the factors responsible for the transition of the oral microbiota from a commensal to a pathogenic relationship with the host. The regulatory forces influencing the oral ecosystem can be divided into three major categories: host related, microbe related, and external factors. Among host factors, secretory immunoglobulin A (SIgA) constitutes the main specific immune defense mechanism in saliva and may play an important role in the homeostasis of the oral microbiota. Naturally occurring SIgA antibodies that are reactive against a variety of indigenous bacteria are detectable in saliva. These antibodies may control the oral microbiota by reducing the adherence of bacteria to the oral mucosa and teeth. It is thought that protection against bacterial etiologic agents of caries and periodontal diseases could be conferred by the induction of SIgA antibodies via the stimulation of the mucosal immune system. However, elucidation of the role of the SIgA immune system in controlling the oral indigenous microbiota is a prerequisite for the development of effective vaccines against these diseases. The role of SIgA antibodies in the acquisition and the regulation of the indigenous microbiota is still controversial. Our review discusses the importance of SIgA among the multiple factors that control the oral microbiota. It describes the oral ecosystems, the principal factors that may control the oral microbiota, a basic knowledge of the secretory immune system, the biological functions of SIgA, and, finally, experiments related to the role of SIgA in oral microbial ecology.

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Microbiological and Immunological Aspects of Experimental Periodontal Disease in Rats: A Review Article

Klausen¹

1991

Journal of Periodontology

165

131

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Animal models in which microbiological and immunological aspects of periodontal disease can be studied prospectively seem well warranted. The rat bears much resemblance to man with respect to periodontal anatomy, development and composition of dental plaque, histopathology of periodontal lesions, and basic immunobiology. Furthermore, reproducible methods are available for assessment of periodontal disease in rats, and detectable periodontal destruction can be induced in a few weeks in these animals without traumatizing periodontal tissues with ligatures. Experimental periodontitis studies in germ‐free rats have confirmed the pathogenicity of several suspected periodontal pathogens (Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Capnocytophaga sputigena, Eikenella corrodens, and Fusobacterium nucleatum). The studies also suggest that the number of periodontal pathogens may be higher than generally believed, since species like Streptococcus sobrinus and Actinomyces viscosus are associated with periodontal bone loss in rats. Studies in rats with congenital or induced immune defects indicate that generalized or selective immunosuppression at the time of infection with periodontal pathogens may aggravate periodontal disease. Studies in immunized rats indicate that periodontal disease can be prevented by immunization against periodontal pathogens. However, it is also possible by immunization to induce periodontal destruction; i.e., the immune system has a destructive potential which should not be overlooked. In the future, the rat model may prove valuable for initial screening of antigen preparations and immunization regimens in the search for a periodontitis vaccine. J Periodontol 1991;62:59–73.

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Effect of local and parenteral immunization on implantation of Actinomyces viscosus T6 in rats

Cited by 4 publications

References 29 publications

Modulation of Actinomyces viscosus colonization of mouse teeth in vivo by immunization with fimbrial adhesins

Modulation of Actinomyces viscosus colonization of mouse teeth in vivo by immunization with fimbrial adhesins

Oral Microbial Ecology and the Role of Salivary Immunoglobulin A

Microbiological and Immunological Aspects of Experimental Periodontal Disease in Rats: A Review Article

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