Effect of local administration of simvastatin on postorthodontic relapse in a rabbit model

AlSwafeeri, Hani; El-Kenany, Walid; Mowafy, Mohamed; Karam, Sahar S.

doi:10.1016/j.ajodo.2017.10.024

Cited by 17 publications

(27 citation statements)

References 44 publications

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“…33,34 Although lipophilic simvastatin has been suggested to exert greater influence on bone turnover when compared with other statins belonging to same class such as atorvastatin, 34 inconsistent effects on OR were noted with the administration of simvastatin. 22,23,26,27 There was a dose-dependent effect of simvastatin on the magnitude of relapse; systemic administration of a low dose of simvastatin decreased OR, 22 whereas systemic administration of a high dose and local administration of a low dose did not affect OR. 23,26,27 Differences in sensitivity of osteoclasts and osteoblasts to different concentrations of simvastatin, experimental animal model, bioavailability associated with route of drug administration, duration of exposure, and experimental designs have been attributed to this varying response of bone remodeling.…”

Section: Systematic Review On Effect Of Drugs On Relapsementioning

confidence: 98%

“…[21][22][23][24][25][26][27] Study Characteristics Table 3 presents the general characteristics of the studies included. Rats were employed as an animal model in all the studies except one 26 that used a rabbit model. OTM was induced using springs placed between either incisors and molars, or incisors and premolars, delivering forces ranging from 50 to 100 cN for a period of 14 to 21 days.…”

Section: Study Selectionmentioning

confidence: 99%

“…27 Administration was systemic in six studies, [21][22][23][24][25]27 whereas local administration was employed in one. 26 Systemic administration involved oral, intraperitoneal, or intravenous. Substances were administered either one time, daily, or weekly, for a maximum period of 4 weeks.…”

Section: Study Selectionmentioning

confidence: 99%

“…All of the studies were assessed as presenting with an unclear RoB and only one study of low risk. 26 Most of the studies presented an unclear RoB pertaining to random sequence generation, allocation concealment, blinding of caregivers/investigators, selection of animals for outcome assessment, and blinding of outcome SYSTEMATIC REVIEW ON EFFECT OF DRUGS ON RELAPSE assessor, as there was inadequate information to arrive at a definitive judgment on RoB. However, with respect to the random housing of the animals, one study presented a high RoB.…”

Section: Rob Within Studiesmentioning

confidence: 99%

“…27 Inconsistent effects were observed with administration of simvastatin. 22,23,26 The results pertaining to the simvastatin group in the study by Vieira et al 27 was not included in the synthesis considering the significant overlap with a previous study. 23…”

Section: Rob Within Studiesmentioning

confidence: 99%

See 4 more Smart Citations

Effect of pharmacological agents on relapse following orthodontic tooth movement:

Veginadu¹,

Tavva²,

Muddada³

et al. 2020

The Angle Orthodontist

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Objectives: To investigate and synthesize systematically the evidence from animal studies pertaining to the effect of pharmacological agents on tooth movement relapse following cessation of orthodontic force application. Materials and Methods: An electronic search was conducted in seven online databases (including gray sources) without restrictions until the third week of April 2019, followed by a hand search in the reference lists of eligible articles. Controlled animal studies investigating the effect of pharmacological agents on tooth movement relapse following orthodontic treatment were selected. Relevant data were extracted from eligible studies and the risk of bias assessment was done using SYRCLE's risk of bias tool. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation tool. Results: The search identified 2354 records, of which 7 studies were deemed eligible for inclusion in the qualitative synthesis, with the majority presenting an unclear risk of bias. Orthodontic relapse was shown to decrease with the administration of pamidronate disodium, atorvastatin, aspirin, and chemically modified tetracycline-3. Inconsistent effects on relapse were observed after the use of simvastatin. The overall quality of retrieved evidence was assessed as low at best.Conclusions: The available evidence shows that the investigated pharmacological agents may demonstrate variable effects on tooth movement relapse following cessation of orthodontic force. Additional evidence of higher quality is required to draw definitive conclusions on their effects and to make potential recommendations for clinical application. (Angle Orthod. 2020;90:598-606.) Although planned, analyses for small-study effects, publication bias, or exploratory subgroup analyses were not feasible because of the inadequate number of studies. The quality of evidence

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