The Effect of Drugs, Hormones, and Diet on Orthodontic Tooth Movement

Krishnan, Vinod; Zahrowski, James J.; Davidovitch, Zéev

doi:10.1002/9781119608912.ch14

Cited by 4 publications

(4 citation statements)

References 139 publications

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“…Even though EARR is a common side effect of orthodontic treatment, noticeable amounts of resorption during a relatively short period, such as the course of orthodontic treatment, is not so common [ 9 , 10 ]. Nonetheless, it has been suggested that individuals who have comorbidities, such as allergy and asthma, that disturb the immune system, might be at a risk of developing severe root resorption [ 20 , 21 ]. Based on the information provided in the included studies, more EARR was noted in the individuals with allergy compared to the control group, while no difference was observed in patients with asthma.…”

Section: Discussionmentioning

confidence: 99%

“…Due to the significant increase in their incidence and prevalence over the last few decades, and the associated socio-economic burden, these diseases have recently gained attention [ 18 , 19 ]. Moreover, it has been suggested that asthma and allergic diseases may be involved in the exacerbation of EARR associated with orthodontic tooth movement [ 20 , 21 ]. The immunologic reaction of chronically allergic and asthmatic patients is characterized by systemic imbalances, resulting in an upregulation in the production of inflammatory mediators [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…The immunologic reaction of chronically allergic and asthmatic patients is characterized by systemic imbalances, resulting in an upregulation in the production of inflammatory mediators [ 22 , 23 ]. These biomolecules might enter the circulatory system, reach the areas of orthodontically induced bone remodelling, and influence cellular recruitment, differentiation and response, and finally, the processes pertinent to tooth movement and EARR development [ 20 , 21 ]. A recent systematic review concluded that individuals with allergy or asthma do not have a predisposition to EARR [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Are asthma and allergy associated with increased root resorption following orthodontic treatment? A meta-analysis

et al. 2023

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Objective The aim of this study is to systematically investigate the available evidence from human studies regarding the association of asthma and/or allergy with EARR. Materials and methods Unrestricted searches in 6 databases and manual searching were performed up to May 2022. We looked for data on EARR after orthodontic treatment in patients with/without asthma or allergy. Relevant data were extracted, and the risk of bias was assessed. An exploratory synthesis was carried out using the random effects model, and the overall quality of the evidence was assessed with the Grades of Recommendation, Assessment, Development, and Evaluation. Results From the initially retrieved records, nine studies met the inclusion criteria (three cohort and six case-control). Overall, increased EARR was observed in the individuals with allergies in their medical history (Standardised Mean Difference [SMD]: 0.42, 95% Confidence Interval [CI]: 0.19 to 0.64). No difference in EARR development was observed among individuals with or without a medical history of asthma (SMD: 0.20, 95% CI: -0.06 to 0.46). The quality of available evidence, excluding studies at high risk, was rated as moderate for the exposure to allergy, and low for the exposure to asthma. Conclusion Increased EARR was noted in individuals with allergies compared to the control group, while no difference was observed for individuals with asthma. Until more data become available, good practice would suggest that it is important to identify patients with asthma or allergy and consider the possible implications.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Are asthma and allergy associated with increased root resorption following orthodontic treatment? A meta-analysis

et al. 2023

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“…Drugs and nutrients given to patients on a regular basis can enter the mechanically stressed paradental tissues and interact with local target cells by circulation. Mechanical forces mixed with one or more of these chemicals may have inhibitory, additive, or synergistic effects (25) .…”

Section: Discussionmentioning

confidence: 99%

Effects of Fixed Orthodontic Appliance with Antihypertensive Drugs on the Body Weight of Experimental Rats

Mahdi,

Saloom,

Kashmola

2023

J Bagh Coll Dent

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Background: This study aims to investigate the effect of fixed orthodontic appliances and/or antihypertensive drugs on the weight of experimental rats. Materials and Methods: Thir-ty-six male Wistar albino rats were subjected to a split-mouth design study, in which an orthodontic appliance was inserted in one side to move the first molar mesially for 2 weeks while the other side acted as a control to tooth movement. The rats were allocated into three groups: group A (n = 12), without any pharmacological treatment; group B (n = 12), subcu-taneous injection of bisoprolol fumarate (5 mg/kg) daily; and group C (n = 12), subcutaneous injection of valsartan (10 mg/kg) daily. A fixed orthodontic appliance with a closing coil spring delivering 50 gm of force was used to move the first molar mesially while the incisors served as an anchor unit. The weight of the rats was measured on days 1 (the day of appli-ance insertion), 7, and 14. Results: No significant (P > 0.05) difference in the body weight of rats was found among the three groups at each time point; however, significant (P < 0.05) weight loss was noted after the first and second week of the experiment in all study groups. Conclusion: The body weight loss of rats following the insertion of a fixed orthodontic ap-pliance could be related to the effects of the appliance rather than the administered antihy-pertensive drugs.

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