Effect of lipid lowering tablet on blood lipid in hyperlipidemia model rats

Kong, Xuejun; Gao, Yanling; Geng, Xiuli; Xie, Guofeng; Hao, Shaojun; Li, Yan; Zhang, Zhengchen

doi:10.1016/j.sjbs.2017.12.002

Cited by 17 publications

(14 citation statements)

References 11 publications

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“…In addition, it is an important risk factor leading to fatty liver, cardiovascular disease and atherosclerosis 2 , and becomes the first killer of human health. It has been reported that nearly 23.6 million people will die from cardiovascular diseases originating from hyperlipidemia by 2030 3 . Furthermore, the incidence of hyperlipidemia is increasing gradually, and may aggravate with aged tendency of population 4 .…”

Section: Introductionmentioning

confidence: 99%

Antihyperlipidemic and hepatoprotective properties of alkali- and enzyme-extractable polysaccharides by Dictyophora indusiata

Wang

Liu

Zhang

et al. 2019

Sci Rep

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Hyperlipidemia, a very common disease throughout the world, usually gives rise to severe liver damages. The current experiment was to investigate the antihyperlipidemic and hepatoprotective properties of alkali- and enzyme-extractable Dictyophora indusiata polysaccharides (Al-DPS and En-DPS) on the hyperlipidemic mice. The results of animal experiment in vivo showed that treatment with Al-DPS or En-DPS could improve the excessive level of lipid profiles in serum and liver, as well as strengthen antioxidant status. In addition, the histopathological observations of liver testified that polysaccharides were capable of attenuating hepatic cell injury. The primary structural features of Al-DPS and En-DPS were demonstrated by HPGPC, HPLC, FT-IR and NMR. Glucose tolerance test manifested that polysaccharides were able to restrain the rise of blood sugar. The results indicated that Al-DPS and En-DPS may be considered as novel compounds to treat hyperlipidemia and also act as hepatoprotective agents.

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Section: Introductionmentioning

confidence: 99%

Antihyperlipidemic and hepatoprotective properties of alkali- and enzyme-extractable polysaccharides by Dictyophora indusiata

Wang

Liu

Zhang

et al. 2019

Sci Rep

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“…The epididymal adipose tissue is a typical white adipose tissue. After the mice are killed, the white adipose tissue of epididymis is weighed and compared with the body weight to get the fat body ratio, which can be used to explain the obesity degree of mice (Kong et al., ). As shown in Table , no significant difference in fat index around the abdominal cavity is determined among the different groups.…”

Section: Resultsmentioning

confidence: 99%

“…In the diagnosis of normal hyperlipidemia, accurate findings can be obtained using TC, TG, HDL‐C, and LDL‐C (Kong et al., ). An increase in TC concentration in the serum causes cardiovascular and cerebrovascular diseases.…”

Section: Resultsmentioning

confidence: 99%

“…HDL‐C is beneficial for cholesterol efflux, which is known as “good cholesterol.” Symptoms of hyperlipidemia can manifest an increase in one or more indicators of TC, TG, and LDL‐C, as well as the decrease in HDL‐C concentrations. The study found that lowering the TC, TG, and LDL‐C levels in serum and increasing the HDL‐C levels can effectively reduce the incidence and mortality of cardiovascular and cerebrovascular diseases (Kong et al., ). LC‐YBJ02 could also decrease the TC, TG, and LDL‐C levels and increase the HDL‐C level, and these effects could reduce lipid.…”

Section: Resultsmentioning

confidence: 99%

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Effects of Lactobacillus Casei YBJ02 on Lipid Metabolism in Hyperlipidemic Mice

Qian

Wang

et al. 2019

Journal of Food Science

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Traditionally fermented yak yogurt as a Tibetan dairy product is high not only in nutrients but also in probiotics. A probiotic strain with a potential lipid reducing effect was isolated from yak yogurt. An animal model for hyperlipidemia was evaluated using the blood index and expression levels of lipid metabolism-related proteins in mice to determine the effect of Lactobacillus casei YBJ02 (LC-YBJ02) on lipid metabolism in hyperlipidemic mice and the underlying mechanism. LC-YBJ02 at different concentrations exhibited certain inhibitory effects on the increase in blood lipid in mice. Particularly, high concentrations of LC-YBJ02 can reduce the cholesterol, triglycerides, and low-density lipoprotein content; however, no significant effect on the high-density lipoprotein of the body has been reported. LC-YBJ02 can effectively increase the reduction in cholesterol level by fecal excretion. In this study, the gene-affecting mouse obesity was determined using experimental results in mice. The expression levels of peroxisome proliferator-activated receptor γ (PPARγ ), CCAAT enhancer binding protein alpha (CEBP)/α, sterol regulatory element binding protein (SREBP)-1c, and FAS could improve because of the high-fat diet in kidney fat. Bacteria at different concentrations could also decrease these expression levels. Specifically, the high concentration of LC-YBJ02 could suppress the expression of PPARγ , CEBP/α, and SREBP-1c; however, the expression of FAS was not significantly inhibited. PPARγ and FAS expression levels in the liver were low, but no significant difference was indicated. CEBP/α and SREBP-1c expression in mouse liver was further detected by Western blot analysis; CEBP/α was considerably low and could not be detected. On the basis of these results, LC-YBJ02 could be used as probiotics through its lipid reduction effects.

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“…Lipid metabolism disorder (LMD) is a major health burden, which is associated with hyperlipidemia, dyslipidemia, cardiovascular, and other metabolic syndrome (MetS) [1,2]. Hyperlipidemia is a significant risk factor for cardiovascular and atherosclerotic diseases, which are characterized by higher levels of triglyceride (TG), total cholesterol (TC), and low-density-lipoprotein cholesterol (LDL-C) and is accompanied by lower levels of high-density-lipoprotein cholesterol (HDL-C) [3]. With considerable changes in lifestyle, the number of patients with LMD has increased dramatically in recent years.…”

Section: Introductionmentioning

confidence: 99%

Effect of Marine Microalga Chlorella pyrenoidosa Ethanol Extract on Lipid Metabolism and Gut Microbiota Composition in High-Fat Diet-Fed Rats

Wan

Liú

et al. 2018

Marine Drugs

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Effects of marine microalga Chlorella pyrenoidosa 55% ethanol extract (CPE55) on lipid metabolism, gut microbiota and regulation mechanism in high fat diet-fed induced hyperlipidaemia rats were investigated. Structure characterizations of major compounds in CPE55 were determined by ultra-performance liquid chromatography-quadrupole/time of flight mass spectrometry (UPLC-Q-TOF-MS/MS). The compositions of gut microbiota in rats were analyzed by high-throughput next-generation 16S rRNA gene sequencing. Oral administration with CPE55 markedly alleviated dyslipidemia through improving adverse blood lipid profile and inhibiting hepatic lipid accumulation and steatosis. CPE55 has downregulated the gene expression levels of acetyl CoA carboxylase, sterol regulatory element-binding transcription factor-1c, and 3-hydroxy-3-methyl glutaryl coenzyme A reductase and upregulated adenosine 5′-monophosphate-activated protein kinase-α. It has also improved the abundance of bacteria Alistipes, Prevotella, Alloprevotella, and Ruminococcus1 and decreased the abundances of Turicibacter and Lachnospira. Turicibacter and Lachnospira were both positive correlations of metabolic phenotypes. The findings above illustrated that CPE55 might be developed as food ingredients to ameliorate lipid metabolic disorders and hyperlipidaemia.

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Effect of lipid lowering tablet on blood lipid in hyperlipidemia model rats

Cited by 17 publications

References 11 publications

Antihyperlipidemic and hepatoprotective properties of alkali- and enzyme-extractable polysaccharides by Dictyophora indusiata

Antihyperlipidemic and hepatoprotective properties of alkali- and enzyme-extractable polysaccharides by Dictyophora indusiata

Effects of Lactobacillus Casei YBJ02 on Lipid Metabolism in Hyperlipidemic Mice

Effect of Marine Microalga Chlorella pyrenoidosa Ethanol Extract on Lipid Metabolism and Gut Microbiota Composition in High-Fat Diet-Fed Rats

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