Effect of leucine on NF-κB pathway in liver regeneration after partial hepatectomy in rats, as determined by miniarray analysis

Ceyhan, Emre; Canbek, Mediha; Uyanoğlu, Mustafa; Özen, Ahmet; Ozen, B Durmus; Berber, Burak; Yaylacı, Ayşe Özmen; Resulzade, Leman

doi:10.4149/bll_2018_017

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…The geraniol (2,6-dimethyltrans-2,6-octadiene-8-ol or 3,7-dimethylocta-trans-2,6-diene-1-ol) used in our experimental study, is a monoterpene alcohol found in rose, lavender and lemon as well (Crespo et al, 2017). Geraniol is known to have antioxidant, anti-inflammatory, antimicrobial (Bhattamisra et al, 2019), antitumor (Cho et al, 2016), hepatoprotective (Mohammed, Tadros, Michel, 2020), cardioprotective, neuroprotective (Rekha, Sivakamasundari, 2018), antidiabetic (Babakumar et al, 2017) regenerative effects (Ceyhan, Canbek, 2017).…”

Section: Discussionmentioning

confidence: 89%

The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats

Danış

Can

Yıldız

et al. 2023

Braz. J. Pharm. Sci.

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Ischemia/reperfusion (I/R) injury is one of the main causes of acute kidney injury. The pathological mechanisms underlying renal I/R injury are complex and remain uncertain. The protective effects of antioxidant properties of geraniol against renal ischemia reperfusion (I/R) damage were investigated in our study. 28 Wistar albino male rats were randomly selected and 4 groups of n = 7 were created. A right kidney nephrectomy surgery was conducted to all groups under anesthesia. 2 ml SF was given to Groups I and II, 50 mg/kg and 100 mg/ kg geraniol were administered intraperitoneally an hour before ischemia to Groups III and IV, respectively. Except for Group I, 45 minutes of ischemia and 4 hours of reperfusion were applied to the groups. At the end of the experiment, parameters related to oxidative stress and inflammation were determined by comparing kidney function, antioxidant enzyme activities and histological changes. Following comparison of BUN and CRE values with CAT and SOD values in tissue samples of Group I and Group II, an increase in Group II was observed and as a result I/R damage formation occurred. Values of geraniol-treated Group III and Group IV approximated to that of Group I, and that the 50 mg/kg geraniol dose proved more effective than 100 mg/kg geraniol.

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Section: Discussionmentioning

confidence: 89%

The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats

Danış

Can

Yıldız

et al. 2023

Braz. J. Pharm. Sci.

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“…Their aromatic properties are mainly attributable to the volatility of geraniol. In recent years, many researchers have centered on the active function of geraniol in the body, that is, its antibacterial [191] and anti-inflammatory [192] functions, improvement of oxidation resistance [192], potential to treat Parkinson's disease [193], promotion of liver regeneration [194], and potential anti-tumor properties [195]. Geranyl is a group derived from vanillin by the removal of hydroxyl, with geranyl pyrophosphate (GPP) and geranyl pyrophosphate (GGPP) among the leading derivatives of geranyl.…”

Section: Geraniolmentioning

confidence: 99%

Regulation Mechanism and Potential Value of Active Substances in Spices in Alcohol–Liver–Intestine Axis Health

Huang,

2024

IJMS

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Excessive alcohol intake will aggravate the health risk between the liver and intestine and affect the multi-directional information exchange of metabolites between host cells and microbial communities. Because of the side effects of clinical drugs, people tend to explore the intervention value of natural drugs on diseases. As a flavor substance, spices have been proven to have medicinal value, but they are still rare in treating hepatointestinal diseases caused by alcohol. This paper summarized the metabolic transformation of alcohol in the liver and intestine and summarized the potential value of various perfume active substances in improving liver and intestine diseases caused by alcohol. It is also found that bioactive substances in spices can exert antioxidant activity in the liver and intestine environment and reduce the oxidative stress caused by diseases. These substances can interfere with fatty acid synthesis, promote sugar and lipid metabolism, and reduce liver injury caused by steatosis. They can effectively regulate the balance of intestinal flora, promote the production of SCFAs, and restore the intestinal microenvironment.

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Effect of leucine on NF-κB pathway in liver regeneration after partial hepatectomy in rats, as determined by miniarray analysis

Abstract: Our results suggested that valine, glutamine, and leucine amino acids may alter expressions of the genes of NF-κB signal pathway. In addition, among these amino acids, glutamine and valine proved to be much more effective on NF-κB signal pathway after the PH (Tab. 1, Ref. 41).

Cited by 2 publications

References 36 publications

The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats

The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats

Regulation Mechanism and Potential Value of Active Substances in Spices in Alcohol–Liver–Intestine Axis Health

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