No abstract

Possible protective effects of geraniol, known as antioxidant properties, were analyzed biochemically and histologically on experimental long-term renal ischemia/reperfusion I/R injury in rats. This study used 3-4 months old male Wistar albino rats and were divided into 4 groups (n = 7) by random selection: Group I (Sham Group), Group II (I/R+SF), Group III (I/R+50 mg/kg geraniol), and Group IV (I/R+100 mg/kg geraniol). A right nephrectomy was performed in all groups under anesthesia. Groups I and II were inoculated with SF (1 ml/kg) and Groups III and IV were inoculated with 50 mg/kg and 100 mg/kg of geraniol, injected intraperitoneally. For Groups II, III, and IV, I/R durations were determined to be 60 mins ischemia and 24 hours reperfusion. At the end of the experiment, Urea (BUN), Creatinine (CRE) activities in the blood serum and the catalase (CAT), glutathione peroxidase (GPx) and Superoxide dismutases (SOD), enzyme activities in kidney tissue were measured. Histologic sections were examined by light microscopy using Hematoxylin & Eosine. As a result, it was determined that 100 mg / kg geraniol against renal I/R injury shows more antioxidant effect and protection than 50 mg / kg geraniol. HIGHLIGHTS • Geraniol (100 mg/kg geraniol) protected the kidneys against oxidative stress. • 100 mg / kg geraniol showed antioxidant properties and supported the antioxidant defense system. • SOD, CAT and GPx activities in renal tissue were analyzed through jel electrophoresis. • Geraniol decreased BUN and CRE levels in kidney parameters in rats. 2 Can, S.; et al.

Ischemia/reperfusion (I/R) injury is one of the main causes of acute kidney injury. The pathological mechanisms underlying renal I/R injury are complex and remain uncertain. The protective effects of antioxidant properties of geraniol against renal ischemia reperfusion (I/R) damage were investigated in our study. 28 Wistar albino male rats were randomly selected and 4 groups of n = 7 were created. A right kidney nephrectomy surgery was conducted to all groups under anesthesia. 2 ml SF was given to Groups I and II, 50 mg/kg and 100 mg/ kg geraniol were administered intraperitoneally an hour before ischemia to Groups III and IV, respectively. Except for Group I, 45 minutes of ischemia and 4 hours of reperfusion were applied to the groups. At the end of the experiment, parameters related to oxidative stress and inflammation were determined by comparing kidney function, antioxidant enzyme activities and histological changes. Following comparison of BUN and CRE values with CAT and SOD values in tissue samples of Group I and Group II, an increase in Group II was observed and as a result I/R damage formation occurred. Values of geraniol-treated Group III and Group IV approximated to that of Group I, and that the 50 mg/kg geraniol dose proved more effective than 100 mg/kg geraniol.

Violence in health, which constitutes a serious problem in Turkey and all over the world has become a global problem. It is admirable by every segment that healthcare professionals today struggle with a global problem such as coronaviruses or serve altruistically in every timed. Nevertheless, while providing services, they somehow experience communication problems with their patients and relatives, and they are subjected to physical, verbal, or psychological violence. In order to prevent violence for employees who are exposed to violence for many reasons; Work should be done on issues such as security, physical structure and equipment, communication, education, and making necessary revisions in the legal regulations on this subject motivates healthcare professionals. Health violence is not only caused by healthcare professionals, patients, or their relatives. The working system of the institutions, high density of the number of patients, the insufficent number of the personnel, the social and global factors, as well as the news in the media that we pay particular attention to in our study, can lead to the emergence of violence. The existence of violence in social life is a result of mass media's inevitably publishing the violence in health. This is why positive developments and negative events in the field of health are published in the media. The purpose of our study is to prepare a stress-free, worry-free working environment for our future healthcare professionals and us without understanding our colleagues.