Effect of lemongrass water extract supplementation on atherogenic index and antioxidant status in rats

Abstract

Cymbopogon citratus (DC) Stapf., commonly known as lemongrass, possesses strong antioxidant and cardiotonic properties. Lemongrass water extract contains several polyphenolic compounds including gallic acid, isoquercetin, quercetin, rutin, catechin and tannic acid. Rutin, isoquercetin catechin and quercetin are the flavonoids most abundantly found in the extract. The extract significantly decreased total cholesterol, low-density lipoprotein and atherogenic index in rats after treatment (p < 0.05). Expression of genes and protein of sterol regulatory element binding protein-1c (SREBP1c) and HMG-CoA reductase (HMGR) was also lowered significantly in treated groups (p < 0.05). Moreover, serum antioxidant capacity increased in treated rats in comparison with untreated ones (p < 0.05) and was associated with decreased serum lipid peroxidation.

Effects of Inclusion of Different Doses of Persicaria odorata Leaf Meal (POLM) in Broiler Chicken Feed on Biochemical and Haematological Blood Indicators and Liver Histomorphological Changes

“…The decreased activity of ALT and AST indicated the hepatoprotective nature of the POLM. The POLM possesses a significant concentration of flavonoids and secondary metabolites, including quercetin, which is believed to be responsible for hepatoprotective activity [ 17 , 61 ]. Farag and El-Rayes [ 62 ] revealed the hepatoprotective effect of quercetin from bee pollen in broilers, which has an ability to restrict oxidative damage to the liver.…”

Therapeutic Potential of Quercetin as an Antiatherosclerotic Agent in Atherosclerotic Cardiovascular Disease: A Review

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Regulatory effect of Phikud Navakot extract on HMG-CoA reductase and LDL-R: potential and alternate agents for lowering blood cholesterol

“…In addition, hydrolic extract of lemongrass [ Cymbopogon citratus (DC) Stapf.] suppressed the expression of sterol regulatory element binding protein-1c and HMGCR in rats [ 31 ]. Furthermore, low concentrations of anthocyanin (200 mg/L) extracted from Thai black sticky rice significantly enhanced the expression of LDL-R in HepG2 cells [ 32 ].…”