Effect of lemon peel flavonoids on anti-fatigue and anti-oxidation capacities of exhaustive exercise mice

Bao, Guili; Zhang, Yinglong; Yang, Xiaoguang

doi:10.1186/s13765-020-00573-3

Cited by 16 publications

(10 citation statements)

References 31 publications

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“…Similar results were obtained in a similar study using 0.05 mL peppermint oil ( M. piperita ) dispersed in mineral water [ 184 ]. These studies reinforce pre-clinical evidence of markedly decreased fatigue in exhaustive exercise by administration of lemon peel oil ( Citrus limon L.) [ 185 ].…”

Section: Essential Oils For Neuroprotection and Modulation Of Mood An...supporting

confidence: 76%

Plant Essential Oils as Healthy Functional Ingredients of Nutraceuticals and Diet Supplements: A Review

Matera¹,

Lucchi²,

Valgimigli

2023

Molecules

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Essential oils (EOs) are mixtures of volatile molecules endowed with health-promoting biological activities that go beyond their role as aromas and natural preservatives and can be exploited to develop functional foods and diet supplements. Their composition is briefly addressed along with regulatory aspects. The potential health benefit of human diet supplementation with EOs is outlined through a review of the recent literature on available clinical trials and preclinical research concerning EOs activity towards: (1) irritable bowel syndrome; (2) inflammatory bowel disease; (3) regulation of microbiota; (4) gastroprotection; (5) hepatoprotection; (6) protection of the urinary tract and diuresis; (7) management of metabolic disorders including hyperglycemia and hyperlipidemia; (8) anti-inflammatory and pain control; (9) immunomodulation and protection from influenza; and (10) neuroprotection and modulation of mood and cognitive performance. The emerging potential in such activities of selected EOs is given focus, particularly green and black cumin, bergamot, orange, myrtle, peppermint, sage, eucalyptus, lavender, thyme, lemon balm, ginger, and garlic.

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Section: Essential Oils For Neuroprotection and Modulation Of Mood An...supporting

confidence: 76%

Plant Essential Oils as Healthy Functional Ingredients of Nutraceuticals and Diet Supplements: A Review

Matera¹,

Lucchi²,

Valgimigli

2023

Molecules

View full text Add to dashboard Cite

show abstract

“…Flavonoids are a type of plant secondary metabolite that are widely present in many minor grains, such as Tartary buckwheat, quinoa, and barley [1][2][3]. In addition to being diverse in variety, flavonoids also possess complex structure types, and they perform many bioactive functions, including antioxidation effects [4,5], antiproliferative effects [6], and antibacterial effects [7,8]. Flavonoids have been commonly used in bacteriostatic therapy and are considered to possess the potential to replace some antibiotics; quercetin, for example, similarly to existing antibiotics, has the potential to treat Pseudomonas aeruginosa infection and its use as an alternative may help to ease the selection pressure due to antibiotic overuse [9].…”

Section: Introductionmentioning

confidence: 99%

Biotransformation of Flavonoids Improves Antimicrobial and Anti-Breast Cancer Activities In Vitro

Hao

Wei

Wang

et al. 2021

Foods

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Coarse cereals are rich in flavonoids, which are bioactive substances with a wide range of functions. Biotransformation is considered an emerging approach to methylate flavonoids, displaying prominent regio- and stereoselectivity. In the current study, liquiritigenin, naringenin, and hesperidin flavonoids were biotransformed using O-methyltransferases that were heterologously expressed in Saccharomyces cerevisiae BJ5464-NpgA. Nuclear magnetic resonance (NMR) spectroscopy was used together with high-resolution mass spectroscopy analysis to determine the structures of the resulting methylated transformants, and their antimicrobial and antiproliferation activities were also characterized. Among the five methylated flavonoids obtained, 7-methoxy-liquiritigenin had the strongest inhibitory effect on Candida albicans SC5314 (C. albicans SC5314), Staphylococcus aureus ATCC6538 (S. aureus ATCC6538), and Escherichia coli ATCC25922 (E. coli ATCC25922), which increased 7.65-, 1.49-, and 0.54-fold in comparison to the values of their unmethylated counterparts at 200, 250, and 400 μM, respectively. The results suggest that 3’-methoxyhesperetin showed the best antiproliferative activity against MCF-7 cells with IC50 values of 10.45 ± 0.45 µM, which was an increase of more than 14.35-fold compared to that of hesperetin. These results indicate that methylation enhances the antimicrobial activities and antiproliferative effects of flavonoids. The current study provides an experimental basis for further research on flavonoids as well as flavonoid-containing crops in the development of antimicrobial and anti-breast cancer drugs in addition to supplementary and health foods. The biotransformation method is ideal, as it represents a means for the sustainable production of bioactive flavonoids.

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“…Excessive and intensive exercise practice can lead to muscle fatigue in humans (5). Several studies are striving to find a promising antifatigue agent for exercise-induced fatigue syndrome (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

The anti-fatigue potential of water-soluble polysaccharides of Semen cassiae on BALB/c mice

Kang

Liu

Chi

et al. 2021

Cell Mol Biol (Noisy-le-grand)

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Fatigue syndrome is a major health problem that affects the voluntary activities of an individual. Particularly, exercise-induced fatigue has become a serious concern in people's health. Since polysaccharides from various medicinal plants have been reported for anti-fatigue effect, the current study deals with the anti-fatigue potential of water-soluble polysaccharides of the Chinese medicinal plant Semen cassiae (Cassia obtusifolia L.) in BALB/c mice. Water-soluble polysaccharides from Semen cassiae were extracted using aqueous solvent (water). An orthogonal test design was employed for the optimization of polysaccharide extraction. The conditions optimized through this design unveiled the raw materials to solvent ratio as 1:30. The optimal temperature and time duration were found to be 80°C and 3.5 h, respectively. The yield of soluble polysaccharides at these specified conditions was 5.42%. Strikingly, the water-soluble polysaccharide from S. cassiae exhibited strong anti-fatigue activity at 100 mg/kg in BALB/c mice. S. cassiae polysaccharide extended the weight-loaded swimming duration in BALB/c mice. In addition, it ameliorated the level of antioxidant enzymes (SOD, GPX) while decreased the blood urea nitrogen, creatine phosphokinase, triglyceride, lactic acid, lactate dehydrogenase, and malondialdehyde levels in blood serum. Moreover, the assessment of the immunomodulatory effect of S. cassia polysaccharides unveiled the enhancement of B-cell and T-cell lymphocytes, denoting the positive effect on physical immunity.

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Effect of lemon peel flavonoids on anti-fatigue and anti-oxidation capacities of exhaustive exercise mice

Cited by 16 publications

References 31 publications

Plant Essential Oils as Healthy Functional Ingredients of Nutraceuticals and Diet Supplements: A Review

Plant Essential Oils as Healthy Functional Ingredients of Nutraceuticals and Diet Supplements: A Review

Biotransformation of Flavonoids Improves Antimicrobial and Anti-Breast Cancer Activities In Vitro

The anti-fatigue potential of water-soluble polysaccharides of Semen cassiae on BALB/c mice

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