Effect of led photobiomodulation on analgesia during labor

Traverzim, Maria Aparecida Dos Santos; Makabe, Sérgio; Silva, Daniela de Fátima Teixeira da; Pavani, Christiane; Bussadori, Sandra Kalil; Fernandes, Kristianne Porta Santos; Motta, Lara Jansiski

doi:10.1097/md.0000000000011120

Cited by 15 publications

(9 citation statements)

References 33 publications

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“…So far, PBM has been applied to treat several human diseases such as stroke, Parkinson's disease, Alzheimer's disease, traumatic brain injury, and psychiatric disorders [115]. Although there have been some studies relevant to light therapy [116,117] in pregnancy, none of them have focused on offspring outcomes in adulthood. In the area of complementary and alternative medicine, several suggested therapies for insomnia might be applied for treating chronodisruption, despite not yet being recommended as standard therapies [118].…”

Section: Light and Circadian Signaling-related Therapy In Human Diseasesmentioning

confidence: 99%

Light and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and Disease

Hsu

Tain

2020

IJMS

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Light is a crucial environmental signal that affects elements of human health, including the entrainment of circadian rhythms. A suboptimal environment during pregnancy can increase the risk of offspring developing a wide range of chronic diseases in later life. Circadian rhythm disruption in pregnant women may have deleterious consequences for their progeny. In the modern world, maternal chronodisruption can be caused by shift work, jet travel across time zones, mistimed eating, and excessive artificial light exposure at night. However, the impact of maternal chronodisruption on the developmental programming of various chronic diseases remains largely unknown. In this review, we outline the impact of light, the circadian clock, and circadian signaling pathways in pregnancy and fetal development. Additionally, we show how to induce maternal chronodisruption in animal models, examine emerging research demonstrating long-term negative implications for offspring health following maternal chronodisruption, and summarize current evidence related to light and circadian signaling pathway targeted therapies in pregnancy to prevent the development of chronic diseases in offspring.

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Section: Light and Circadian Signaling-related Therapy In Human Diseasesmentioning

confidence: 99%

Light and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and Disease

Hsu

Tain

2020

IJMS

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“…In this context, photobiomodulation (PBM) is widely known for its therapeutic benefits in the protection and regeneration of tissues [18][19][20][21][22][23]. Studies have demonstrated that PBM can reduce pain and inflammation [23][24][25], improve cancer management [26], and stimulate healing and tissue repair [20][21][22][27][28][29][30][31]. PBM is defined by the use of visible light to stimulate biological functions in a non-thermal and non-cytotoxic manner.…”

Section: Introductionmentioning

confidence: 99%

Management of otitis externa with an led-illuminated gel: a randomized controlled clinical trial in dogs

et al. 2020

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Background: Canine otitis externa is a painful condition which can be challenging to treat due to difficulties in the administration of otic medication. This can be due to lack of owner compliance in the application of ear drops or due to the resentment that some dogs demonstrate when attempts are made to administer topical medication into a sensitive ear canal. The aim of the study was to assess the efficacy of a topical LED-illuminated gel (LIG) in canine otitis externa in comparison to standard of care therapy. Dogs with spontaneous otitis externa were randomly allocated in three groups: groups QW received LIG once weekly; BW received LIG twice weekly; group C received enrofloxacin and silver sulfadiazine twice daily. LIG consists of a topical application of a gel containing chromophores that, when illuminated by a LED lamp, re-emit fluorescent light which can stimulate physiological responses, promoting healing and controlling bacteria. The evaluation protocol (T 0 to T 5) considered clinical assessment (OTIS-3-index-scoring-system; pruritus-severity-scale; pain-severity-score; aural temperature), cytological scoring system, quali-quantitative bacteriologic assessment. Results: All groups (QW, n = 21; BW, n = 23; C, n = 20) showed improvement during the study (QW: P < 0.02 for cytological and pain scores, P < 0.003 for bacteriologic assessment, P < 10 − 4 for pruritus, total OTIS-3 and temperature assessments; BW: P < 10 − 4 for all clinical, cytological and bacteriologic assessments; C: P < 0.02 for all clinical and cytological assessments, P < 10 − 4 for bacteriologic assessment). The highest clinical score reduction occurred in Group BW (P < 0.014 in T 3 ; P < 0.001 in T 4 and P < 10 − 4 in T 5). BW reached the clinically relevant effect level at T 3 (− 3.26 ± 1.21 levels), QW reached it at T 4 (− 3.24 ± 0.99), C did not reach it. No differences between groups were seen in the reduction of CFU/mL (T 0-T 5). Conclusions: All treatment groups showed a positive clinical effect. LIG administered twice-a-week was the most favourable protocol of the study. LIG may be considered beneficial in the management of canine otitis externa; it seems to be effective in controlling the clinical condition, including the signs of inflammation and local pain, the bacterial growth, and it may help increasing treatment compliance.

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“…To analyze the effect of LED on analgesia during labor, the following variables were assessed: (1) perception of pain, (2) fetal well-being assessed by cardiotocography or intermittent auscultation, (3) Apgar score at minutes 1 and 5 after birth, and (4) labor duration. 15 Pain perception was assessed by means of the visual analog scale (VAS) with scores and a continuous ruler varying from 0 to 10, before and after the intervention. The scale had a size of 10 cm, and patients were given an explanation that 10 meant the strongest pain they had ever felt and 0 meant absence of pain, and then they would point to a number on the scale that corresponded to the pain they were feeling at the time.…”

Section: Methodsmentioning

confidence: 99%

The Effect of Photobiomodulation on Analgesia During Childbirth: A Controlled and Randomized Clinical Trial

Traverzim

Sobral

Fernandes

et al. 2021

Photobiomodulation, Photomedicine, and Laser Surgery

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Background: Pain during labor can be a barrier when choosing vaginal delivery. In an attempt to relief pain during labor, several pharmacological and nonpharmacological methods are proposed. Objective: To assess the effect of light-emitting diode (LED) photobiomodulation on analgesia during labor. Methods: A clinical trial was conducted with 29 women who were divided into two groups: G1 (experimental group-LED) and G2 (control group-hot shower). In the experimental group, an LED plate with red and infrared merged [red 660 -20 nm, 5 mW/cm 2 , 3 J per LED (108 J) and infrared 850 -20 nm, 5 mW/cm 2 , 3 J per LED (108 J), total energy = 216 J] was placed on the subjects' dorsal region, at the level of T10 to S4, for 10 min, with the plate automatically turning off. Hot shower at controlled temperature was offered for 30 min. To verify the effect of LED on analgesia during labor, the following variables were assessed: (1) perception of pain, (2) fetal well-being assessed by cardiotocography or intermittent auscultation of fetal heart rate, (3) Apgar score at minutes 1 and 5 after birth, and (4) labor duration. Results: There was a statistically significant difference ( p < 0.05) in pain reduction evidenced by a millimetric visual scale, before and after application on G1-LED (7.92 -1.78). Regarding the other variables, there was no statistical difference between the groups when comparing fetal well-being, Apgar score and labor duration. Conclusions: It is concluded that LED can be considered an alternative, since it caused pain reduction without changing other parameters during labor, compared with hot shower, a method included in hospital protocols, proving to be safe. Clinical Trial Registration number: NCT 03496857.

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Effect of led photobiomodulation on analgesia during labor

Cited by 15 publications

References 33 publications

Light and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and Disease

Light and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and Disease

Management of otitis externa with an led-illuminated gel: a randomized controlled clinical trial in dogs

The Effect of Photobiomodulation on Analgesia During Childbirth: A Controlled and Randomized Clinical Trial

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