Effect of lead on lipid peroxidation in liver of rats

Sandhir, Rajat; Gill, Kiran Dip

doi:10.1007/bf02789081

Cited by 132 publications

(82 citation statements)

References 20 publications

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“…Reported data state that a marked increase in the total sulfhydryl group was observed in rat liver with blood lead level (BLL) higher than 80 μg/dl. This increase may be attributed to the possible induction of MT by Pb and enhanced peroxidative damage to the membrane [18]. It has also been reported that chronic exposure of an organism to Zn on a long-term basis results in enhanced synthesis of metallothioneins [17,19].…”

Section: Resultsmentioning

confidence: 95%

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The effects of lead and zinc ion exposure on the antioxidant status of mice liver

Šulinskienė¹,

Sadauskienė²,

Ivanov³

2011

Biologija

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The present study was conducted to investigate the effect of lead (Pb) and / or zinc (Zn) ions on the content of metallothionein (MT), reduced glutathione (GSH) and malondialdehyde (MDA) in mouse liver.Two weeks of mice intraperitoneal treatment with ZnSO 4 and Pb(CH 3 COO) 2 solutions, increased the content of MT by 25% and 55%, respectively. Mice pre-treatment with ZnSO 4 for 20 min before Pb(CH 3 COO) 2 injections, attenuated the effect of Pb 2+ and partly reduced (by 30%) the increase of MT content in mice liver. Two weeks of administration with Pb(CH 3 COO) 2 solution, induced the decrease of GSH content by 22% comparing to the control. Treatment with ZnSO 4 didn't have any effect on the content of GSH. Pre-treatment with ZnSO 4 for 20 min before Pb(CH 3 COO) 2 injections decreased GSH content in mice liver by 48% as compared to the control group of mice. Neither Pb 2+ nor Zn 2-caused any remarkable alterations on MDA content in liver of mice.

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Section: Resultsmentioning

confidence: 95%

“…Under oxidative stress, GSSG is reduced to GSH by glutathione reductase (GR), an indirect component of the antioxidant defense system. It was suggested that lead inhibits GR by attacking the disulfide group on the active site of this enzyme [18]. These reasons might explain why the decrease of GSH was determined.…”

Section: Resultsmentioning

confidence: 99%

The effects of lead and zinc ion exposure on the antioxidant status of mice liver

Šulinskienė¹,

Sadauskienė²,

Ivanov³

2011

Biologija

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“…These data together with the histopathological examination of the liver clearly showed that the toxins actually damaged the liver, but improved its condition by the treatment with GO and Vitamin E. Ethanol due to its ability to diffuse across biological membranes, may affect the absorption of various exogenous compounds and thus potentiate the toxic effects of several toxicants, including heavy metals such as lead [5]. The damaging effects of lead salt may be due to its action on SH group enzymes [24][25][26] e.g. catalase as for any other heavy metal such as Cd or Hg.…”

Section: Discussionmentioning

confidence: 99%

Garlic Oil and Vitamin E Prevent the Adverse Effects of Lead Acetate and Ethanol Separately as well as in Combination in the Drinking Water of Rats

Sajitha

Jose

Andrews

et al. 2010

Indian J Clin Biochem

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Daily feeding of drinking water containing lead acetate (160 mg/l) or 10% alcohol by volume or a combination of both to rats for a month produced certain deleterious effects through oxidative stress. Both heavy metal lead and alcohol are capable of doing such damages. The deleterious alterations observed were in the parameters of blood, serum and tissues, viz; Hb, Pb, proteins, lipids, lipid per oxidation, Vitamins C and E levels and enzyme activities of AST, ALT, and catalase. Simultaneous feeding of either of the two antioxidants garlic oil (GO) and vitamin E at equal doses of 100 mg/kg/day, to the rats counteracted the deleterious effects of the above two chemicals significantly. The maximum damage was brought about by feeding of drinking water containing both lead acetate and alcohol. The protective effects of GO and Vitamin E were not significantly different. The mechanism of actions of the Vitamin E and GO is probably due to their efficiency as detoxifying agents and antioxidants, to scavenging free radicals as well as an independent action of GO on the removal of lead salt as lead sulfide.

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“…GSH acts as an electron donor for the reduction of arsenicals and arsenicals had high affinity to GSH. Various researchers observed a direct correlation between lead concentration and lipid peroxidation [16,17].…”

Section: Journal Of V Journal Of Veterinary Science and Eterinary Scienmentioning

confidence: 99%

Effect of Heavy Metals on Oxidative Stress Parameters of Cattle Inhabiting Buddha Nallah Area of Ludhiana District in Punjab

Dhaliwal¹,

Chhabra²

2016

J Vet Sci Technol

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In the present study, heavy metals' (Pb, Cd, As, Ni) status and their effect on oxidative stress parameters in cattle inhabiting Buddha Nallah was assessed. A total of 63 cows were randomly selected for the study and blood plasma samples were obtained from the animals and analyzed for heavy metals and for various oxidative stress parameters viz., GSH (Reduced glutathione), malonyldialdehyde (MDA) and superoxide dismutase (SOD). A significant (p<0.01) increase in plasma heavy metals was recorded in the cows. A significant decrease in GSH (p<0.01) and SOD (p<0.05) and significant increase (p<0.01) in MDA levels was indicative of oxidative damage which may lead to detrimental health hazards in the animals inhabiting Buddha Nallah area of Ludhiana district.

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Effect of lead on lipid peroxidation in liver of rats

Cited by 132 publications

References 20 publications

The effects of lead and zinc ion exposure on the antioxidant status of mice liver

The effects of lead and zinc ion exposure on the antioxidant status of mice liver

Garlic Oil and Vitamin E Prevent the Adverse Effects of Lead Acetate and Ethanol Separately as well as in Combination in the Drinking Water of Rats

Effect of Heavy Metals on Oxidative Stress Parameters of Cattle Inhabiting Buddha Nallah Area of Ludhiana District in Punjab

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