Garlic Oil and Vitamin E Prevent the Adverse Effects of Lead Acetate and Ethanol Separately as well as in Combination in the Drinking Water of Rats

Sajitha, G R; Jose, Regi; Andrews, Anne M.; Ajantha, K.; Augustine, Paul; Augusti, K. T.

doi:10.1007/s12291-010-0042-x

Cited by 42 publications

(29 citation statements)

References 41 publications

(39 reference statements)

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“…Garlic also showed good protective effects against experimental intoxication with Cd and Hg and organo metallic compounds according to various workers [75]. The authors of this paper also showed the beneficial effects of garlic oil and onion oil in ameliorating the toxic effects of lead acetate in the drinking water of rats [6]. These oils helped to remove lead salt from the blood of the rats fed with lead acetate along with and without alcohol.…”

Section: Antidote For Heavy Metal Poisoning and Other Toxinsmentioning

confidence: 54%

“…The so called vitamins C in citrus fruits, E in germinated seeds and vegetable oils, and b-carotene in carrots, lycopene in tomatoes, EGCG in green tea [3], sulfoxides and polysulfoxides in alliums or their extracts [4][5][6][7] may be in minute quantities only in each serve of the items in a menu. Such minute quantities of AOs mostly present in much acclaimed Mediterranean, Chinese and Indian foods may give a guideline for arriving at a moderate concentration of AOs for a healthy practice of foods.…”

Section: Antioxidant Vitamins a C And E And B-carotene Are Notmentioning

confidence: 99%

“…are used in plenty. All the above food materials contain a cock tail of AOs as described in the book on nutraceuticals and else where [4][5][6][7][8][9]. Daily use of any such plant product as a food supplement singly or in combination may help the body to scavenge the day to day production of ROS and RNS due to alcoholism, smoking, over eating or any injury/disease in the body.…”

Section: Antioxidant Vitamins a C And E And B-carotene Are Notmentioning

confidence: 99%

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A Rethinking on the Benefits and Drawbacks of Common Antioxidants and a Proposal to Look for the Antioxidants in Allium Products as Ideal Agents: A Review

et al. 2011

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This review article on the beneficial uses of Allium antioxidants tries to give some answers to the recent doubts raised by Singh et al. (Ind J Clin Biochem 25(3):225-243, 2010) against the claim of some researchers that Antioxidants (AOs) are miraculous molecules. Many people still believe that vitamins like A, C and E are the only true AOs that play important role in the corrections of metabolic derangements in life style diseases and hence all their faults are attributed to the failures of AOs as a class. This is quite unfair as there are many other natural AOs that do equal or even better AO action than the vitamins. Such is the case with the Allium S-alkyl sulfoxide aminoacids and their breakdown products viz, the various poly sulfides and their oxides e.g. allicin and ajoene type compounds which trap electrons mainly. It is true that antioxidant vitamins and b-carotene a precursor of Vitamin A bring about problems as prooxidant or as agents that block some metabolic pathways and gene expression. Again the argument that AOs cannot improve the level of antioxidant enzymes like SOD, catalase and glutathione Px is also not universal. Actually allium AOs can even spare the use of antioxidant vitamins in the body and enhance the action of antioxidant enzymes and supply of ATP and other nutrients to the tissues as the former are good vasodialators and promoters of membrane permeability. The use of AOs should be selective and moderate.

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Section: Antidote For Heavy Metal Poisoning and Other Toxinsmentioning

confidence: 54%

Section: Antioxidant Vitamins a C And E And B-carotene Are Notmentioning

confidence: 99%

Section: Antioxidant Vitamins a C And E And B-carotene Are Notmentioning

confidence: 99%

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A Rethinking on the Benefits and Drawbacks of Common Antioxidants and a Proposal to Look for the Antioxidants in Allium Products as Ideal Agents: A Review

et al. 2011

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“…(19) Tocopherol when given to lead-exposed rats can neutralize lead toxicity by cleaving free radicals and preventing oxidative stress. (20) Tocopherol as an antioxidant acts by competitive inhibition of lead and prevents the formation of lipid peroxides as a result of lead exposure.…”

Section: Discussionmentioning

confidence: 99%

Red fruit oil increases trophoblast cells and decreases caspase-9 expression in placenta of lead exposed mice

Sumarsono

Widjiati

Susilowati

2016

UnivMed

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BACKGROUND Lead is able to pass through the placental barrier and interfere with fetal development. Red fruit has high antioxidant activity, due to carotenoids (pro-vitamin A), tocopherols (vitamin E) and unsaturated fatty acids. This study aims to examine the effect of red fruit oil towards placenta in pregnant mice before lead exposure. METHODS This was a laboratory experimental post test only study, using 20 pregnant mice (Mus musculus) that were randomized into five groups. The negative control group was not exposed to lead; intervention group 0 (P0) was exposed to lead at 0.011 mg/20 g BW/day on days 6-15 of gestation. The intervention groups P1-P3 were given red fruit orally at 0.3 mL/20 g BW/day, 0.8 mL/20 g BW/day, 0.9 mL/20 g BW/day, respectively, before lead exposure. Normal trophoblast cell count and caspase-9 expression of trophoblasts were calculated. One-way ANOVA, Kruskal-Wallis and Mann Whitney tests were used to analyze the data. RESULTS The intervention groups P2 and P3 given red fruit at 0.8 mL/20 g BW/day and 0.9 mL/20 g BW/day showed a significant increase in normal trophoblast cell count of 88.2% (p=0.024) and a decrease in caspase-9 expression of 70.8% compared with P0 to which was not given red fruit (p=0.020). CONCLUSION Red fruit increased normal trophoblast cell count by 88.2% and decreased caspase-9 expression by 70.8% in pregnant mice before lead exposure. It should be noted that red fuit may prevent oxidative damage to cells.

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“…Swati et al [6] reported that allium plants such as garlic has some beneficial effects in preventing the heavy metals such as nickel and chromium induced alteration in serum lipid profile. The preventive role of garlic oil and Vitamin E against the adverse effects of lead acetate and ethanol separately as well as in combination in the drinking water of rats were previously reported by our team [7]. So for very little work was carried out for the prevention of lead induced oxidative stress by using nutritional medicines (neutraceuticals).…”

Section: Introductionmentioning

confidence: 95%

Prophylactic Effects of Garlic Oil and Onion Oil Fractions as Compared to Vitamin E on Rats Orally Fed with Lead Acetate Solution

2016

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Heavy metal pollution is a global public health challenge due to its stable and persistent environmental contamination. Of these lead is considered to be one of the most common ubiquitous and industrial pollutants and at low concentration it exerts extensive damages to the tissues. Daily feeding of lead acetate solution (Dose: 10 mg/ kg/day) to normal rats for a month adversely altered the parameters of blood, serum and tissues, viz; RBC, WBC, Hb, ë-ALAD (Delta amino levulinic acid dehydratase), Pb content, lipids, oxidized lipids (TBARS), vitamins C and E and GSH levels and activities of AST, ALT and antioxidant enzymes viz; catalase, GR, Gpx and SOD. In order to study whether antioxidants have any effect to counteract the toxicity of lead we have selected comparatively better active allium fractions for the study viz: polar fraction of garlic (PFG) and polar fraction of onion (PFO). On feeding of these active fractions of garlic and onion oils i.e. their polar fractions and vitamin E (Dose 100 mg/kg/day) separately for a month along with or without lead acetate to rats each nutraceutical and vitamin E counteracted the adverse effects of Pb significantly (p B 0.05). Their effects are in the order of PFG [ PFO [ Vitamin E. All these results point out that garlic and onion oils contain natural disulfoxide compounds which act as antioxidant and anti toxic to lead compounds. Their comparative differences in action may be due to the presence and position of double bonds and disulfide oxide bonds in their molecules. i.e., in PFG the allyl disulfide oxide group is present and in PFO saturated methyl and propyl groups and unsaturated propenyl group are present in place of allyl groups. The former group confers a better antioxidant activity on PFG, while the latter groups confer a lesser activity on PFO.

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Garlic Oil and Vitamin E Prevent the Adverse Effects of Lead Acetate and Ethanol Separately as well as in Combination in the Drinking Water of Rats

Cited by 42 publications

References 41 publications

A Rethinking on the Benefits and Drawbacks of Common Antioxidants and a Proposal to Look for the Antioxidants in Allium Products as Ideal Agents: A Review

A Rethinking on the Benefits and Drawbacks of Common Antioxidants and a Proposal to Look for the Antioxidants in Allium Products as Ideal Agents: A Review

Red fruit oil increases trophoblast cells and decreases caspase-9 expression in placenta of lead exposed mice

Prophylactic Effects of Garlic Oil and Onion Oil Fractions as Compared to Vitamin E on Rats Orally Fed with Lead Acetate Solution

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