Effect of lead exposure on liver lipid peroxidative and antioxidant defense systems of protein-undernourished rats

Adegbesan, Bukunola Oluyemisi; Adenuga, Gbenga A.

doi:10.1007/bf02685932

Cited by 55 publications

(26 citation statements)

References 13 publications

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“…It has been shown to cause permanently reduced cognitive capacity (intelligence) in children, with apparently no lower threshold to the dose-response relationship (unlike other heavy metals such as mercury) [71]. This neurotoxicity was later found to be associated with lead-induced production of ROS which caused increase or decrease in the levels of lipid peroxidation or antioxidant defense mechanisms in the brain of experimental animals, and the effects were concentration dependent [72–74]. …”

Section: Leadmentioning

confidence: 99%

Biomedical Implications of Heavy Metals Induced Imbalances in Redox Systems

Sharma

Singh

Siddiqi

2014

BioMed Research International

321

221

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Several workers have extensively worked out the metal induced toxicity and have reported the toxic and carcinogenic effects of metals in human and animals. It is well known that these metals play a crucial role in facilitating normal biological functions of cells as well. One of the major mechanisms associated with heavy metal toxicity has been attributed to generation of reactive oxygen and nitrogen species, which develops imbalance between the prooxidant elements and the antioxidants (reducing elements) in the body. In this process, a shift to the former is termed as oxidative stress. The oxidative stress mediated toxicity of heavy metals involves damage primarily to liver (hepatotoxicity), central nervous system (neurotoxicity), DNA (genotoxicity), and kidney (nephrotoxicity) in animals and humans. Heavy metals are reported to impact signaling cascade and associated factors leading to apoptosis. The present review illustrates an account of the current knowledge about the effects of heavy metals (mainly arsenic, lead, mercury, and cadmium) induced oxidative stress as well as the possible remedies of metal(s) toxicity through natural/synthetic antioxidants, which may render their effects by reducing the concentration of toxic metal(s). This paper primarily concerns the clinicopathological and biomedical implications of heavy metals induced oxidative stress and their toxicity management in mammals.

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Section: Leadmentioning

confidence: 99%

Biomedical Implications of Heavy Metals Induced Imbalances in Redox Systems

Sharma

Singh

Siddiqi

2014

BioMed Research International

321

221

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“…It can disturb cellular signaling and metabolism, ionic transportation, and enzyme activities by replacing mono- and bivalent cations [36]. In addition to its ionic activity, Pb triggers the generation of reactive oxygen species (ROS), which promotes oxidative damage to lipids, DNA, and proteins [37]. Accordingly, elevated LPO and NO was accompanied by a depletion of cellular antioxidants within the liver and kidneys of G. nanus , demonstrating an oxidative stress status.…”

Section: Discussionmentioning

confidence: 99%

Effects of Mining Activities on Gerbillus nanus in Saudi Arabia: A Biochemical and Histological Study

Almalki

Ajarem

Altoom

et al. 2019

Animals

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Simple SummaryMining is the extraction of materials of economic importance from the earth. It is an important source of employment and economic development. However, mining activities can impact on biodiversity, the environment, and human health, mainly through the emission of large quantities of heavy metals. Our objective was to investigate the impacts of gold mining on the Balochistan gerbil, a rodent that inhabits the natural environments of Saudi Arabia. Our results demonstrate the accumulation of heavy metals in the soil, in Arabian boxthorn plants, and in the different tissues of the gerbils. In addition, the gerbils exhibited liver, kidney, and lung injury associated with decreased antioxidants. These data may be of public interest and may call attention to the evaluation of the impacts of gold mining on the environment and nearby communities.AbstractMining can impact the environment, biodiversity, and human health through direct and indirect practices. This study investigated the effects of gold mining on Gerbillus nanus, in relation to organ dysfunction and redox imbalance. Soil samples, Lycium shawii, and G. nanus were collected from a site near a mining plant, and a control site. Soil and L. shawii samples from the mining site showed significantly higher cadmium (Cd), copper (Cu), mercury (Hg), arsenic (As), zinc (Zn), lead (Pb), and vanadium (V) levels. Hepatic, renal, and pulmonary Cd, Pb, Hg, Zn, Cu, Fe, As, and V concentrations were significantly higher in G. nanus from the mining site. Markers of liver and kidney function were elevated in serum, and several histological manifestations were observed in the liver, kidney, and lung of G. nanus from the mining site. Malondialdehyde and nitric oxide levels increased, and glutathione and antioxidant enzymes decreased in the liver and kidney of G. nanus. In conclusion, mining practices trigger tissue damage and oxidative stress in G. nanus that live close to the mining site. These findings can represent a scientific basis for evaluating the environmental and health impacts of mining on nearby communities.

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“…The results showed that low dose of mercury could incur oxidative stress and hepatic damage. Besides mercury, lead was also found to exacerbate liver lipid peroxidation in protein-undernutrited rats, in which the study also suggested that free radicals is a pathological mechanism for hepatotoxicity of lead [ 59 ]. Microcystins are algae toxins produced by cyanobacteria, kind of cyclic nonribosomal peptides, possessing hepatotoxicity that may cause severe injury to the liver.…”

Section: Oxidative Stress In Liver Diseasesmentioning

confidence: 99%

The Role of Oxidative Stress and Antioxidants in Liver Diseases

Tan

Wang

et al. 2015

IJMS

1,351

918

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A complex antioxidant system has been developed in mammals to relieve oxidative stress. However, excessive reactive species derived from oxygen and nitrogen may still lead to oxidative damage to tissue and organs. Oxidative stress has been considered as a conjoint pathological mechanism, and it contributes to initiation and progression of liver injury. A lot of risk factors, including alcohol, drugs, environmental pollutants and irradiation, may induce oxidative stress in liver, which in turn results in severe liver diseases, such as alcoholic liver disease and non-alcoholic steatohepatitis. Application of antioxidants signifies a rational curative strategy to prevent and cure liver diseases involving oxidative stress. Although conclusions drawn from clinical studies remain uncertain, animal studies have revealed the promising in vivo therapeutic effect of antioxidants on liver diseases. Natural antioxidants contained in edible or medicinal plants often possess strong antioxidant and free radical scavenging abilities as well as anti-inflammatory action, which are also supposed to be the basis of other bioactivities and health benefits. In this review, PubMed was extensively searched for literature research. The keywords for searching oxidative stress were free radicals, reactive oxygen, nitrogen species, anti-oxidative therapy, Chinese medicines, natural products, antioxidants and liver diseases. The literature, including ours, with studies on oxidative stress and anti-oxidative therapy in liver diseases were the focus. Various factors that cause oxidative stress in liver and effects of antioxidants in the prevention and treatment of liver diseases were summarized, questioned, and discussed.

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Effect of lead exposure on liver lipid peroxidative and antioxidant defense systems of protein-undernourished rats

Cited by 55 publications

References 13 publications

Biomedical Implications of Heavy Metals Induced Imbalances in Redox Systems

Biomedical Implications of Heavy Metals Induced Imbalances in Redox Systems

Effects of Mining Activities on Gerbillus nanus in Saudi Arabia: A Biochemical and Histological Study

The Role of Oxidative Stress and Antioxidants in Liver Diseases

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