Effect of landfill leachate on oxidative stress of brain structures and liver from rodents: Modulation by photoelectrooxidation process

Bertoldi, Karine; Spindler, Christiano; Moysés, Felipe dos Santos; Vanzella, Cláudia; Lovatel, Gisele Agustini; Elsner, Viviane Rostirola; Rodrigues, Marco Antônio Siqueira; Siqueira, Ionara Rodrigues

doi:10.1016/j.ecoenv.2012.08.001

Cited by 17 publications

(9 citation statements)

References 60 publications

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“…Leachate dose‐dependent genotoxicity could be induced by the relatively high concentrations of heavy metals (Ni, Pb, Cr, Cd, Mn), high concentration of organic biorefractory compounds (COD, color) and/or nitrogen species (Adamsson et al, ; Gajski et al, ; Rodrigues et al, ). Some studies have reported that the presence of dioxins, polychlorinated biphenyls, polyaromatic hydrocarbons (not measured in the present study) and PAEs could also impair DNA integrity (Ernst et al, ; Kleinsasser et al, ; Toufexi et al, ), and the possible mechanism of leachate‐induced DNA damage might be related with its ability to enhance oxidative stress caused by several xenobiotics (Bertoldi et al, ; Eckers et al, ; Patlolla et al, ; Shim et al, ). On the other hand, leachate absorption into HepG2 cells could change the pH outside and within cells, which might change the structures of DNA (Li et al, ).…”

Section: Discussionmentioning

confidence: 65%

Genotoxic effects of old landfill leachate on HepG2 cells after nitration/ultrafiltration/reverse osmosis membrane treatment process

Cheng

Zhao

Yin

2017

J of Applied Toxicology

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Toxicity assessment of nitration/ultrafiltration/reverse osmosis (nitration/UF/RO) project, which has recently been widely used as an efficient process with applications in practical leachate treatment, was very limited. In the present study, DNA damage of leachates was investigated before and after the nitration/UF/RO process by a battery of assays with human hepatoma cells. Methyletrazolium assay showed a high cytotoxicity of 97.1% after being exposed to the highest concentration of raw leachate for 24 h, and a cytotoxicity of 26% in effluent at a concentration of 30% (v/v). Both comet assay (24 h) and γH2AX flow cytometer assay (3 h) showed increased levels of DNA damage in cells exposed to raw leachate and after nitration/UF-treated leachate followed by a significant increase of 7-ethoxyresorufin-O-deethylase activity. However, the effluent after nitration/UF/RO treatment showed no significant difference compared to negative control for γH2AX flow cytometer assay but slight DNA damage at concentrations of 20% and 30% (v/v) as well as increase of 7-ethoxyresorufin-O-deethylase. Analysis showed that nitration/UF/RO process exhibited high removal of physicochemical indexes and significant reduction of toxic and genotoxic effects of leachate, but still demands an improvement to reduce all possible negative risks to the environment and humans. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 65%

Genotoxic effects of old landfill leachate on HepG2 cells after nitration/ultrafiltration/reverse osmosis membrane treatment process

Cheng

Zhao

Yin

2017

J of Applied Toxicology

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“…Se sabe, por ejemplo, que el BDNF es crucial para los procesos de señaliza-ción por calcio en neuronas glutamatérgicas que posteriormente exhiben fenómenos de plasticidad (Cechetti et al, 2008;Farmer et al, 2004;van Praag, 2008;van Praag, Kempermann & Gage, 1999;Zheng et al, 2006). También se ha demostrado que el uso de antagonistas de BDNF o la alteración en su expresión disminuyen la supervivencia neuronal y el aprendizaje (Abel & Rissman, 2013;Berchtold et al, 2010;Bertoldi et al, 2012;Elsner et al, 2011;Elsner et al, 2013;Gomez-Pinilla, Zhuang, Feng, Ying & Fan, 2011;Kaliman et al, 2011;Kong et al, 2010;Zajac et al, 2010). De acuerdo a lo anterior, es claro que muchas de las modificaciones estructurales y funcionales ocasionadas por actividad física estarían mediadas por interacciones tanto a nivel celular como posiblemente genético.…”

Section: Enriquecimiento Ambiental Ejercicio Y Actividad Físicaunclassified

Efectos del estrés sobre los procesos de plasticidad y neurogénesis: una revisión

Zarate¹,

Parra²,

Acevedo-Triana

et al. 2014

Univ Psychol

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r e S u M e n Grandes esfuerzos han sido llevados a cabo para entender los componentes psicobiológicos del estrés y de algunas de las psicopatologías relacionadas con él, tales como los trastornos de ansiedad (ansiedad generalizada o crisis de pánico) e incluso la depresión. Existen evidencias de que procesos como la neurogénesis y la plasticidad se ven enormemente afectados por muchos factores, entre ellos el estrés. En esta revisión se presentan algunos de los principales conceptos sobre la relación entre estrés, plasticidad y neurogé-nesis, a los que se ha llegado a partir de investigaciones realizadas -principalmente en modelos animales-, desde hace algunas décadas. Se realizará una diferenciación entre los efectos ocasionados por estrés crónico y agudo, tratando de establecer las interacciones que sobre estos efectos ejercen algunas variables tales como el género o el rango de edad, se enfatizarán los efectos comportamentales para finalmente revisar algunas de las formas de intervención actualmente más usadas para el tratamiento del estrés. Palabras clave estrés; plasticidad; neurogénesis a B S t r a C tThere is a growing interest in the comprehension of psychobiological mechanisms underlying stress and its relationships with many psychopathologies such as anxiety (i.e. generalized anxiety and panic attacks) or depression. There are several reports on the effects of stress on neurogenesis and plasticity. This review will discuss some of the core concepts on the relation between stress, plasticity and neurogenesis obtained during the last decades from research -mainly based in the use of animal models. The distinguishable effects between acute and chronic stress will also be discussed in relation to other factors as genre and age with an emphasis on behavioral effects. Some current therapeutic approaches will be reviewed as well.

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“…All these researches evaluate the treatment for leachates containing COD from 560 to 5200 mg L À1 and ammoniacal nitrogen from 14 to 1100 mg L À1 . One technique that has been widely studied for the treatment of complex effluents is photoelectrooxidation (Bertoldi et al, 2012;Catanho et al, 2006;da Silva et al, 2014;Molina et al, 2013;Rodrigues et al, 2008;Siqueira et al, 2011;Xavier et al, 2011), which is a combination of electrochemical process and heterogeneous photocatalysis.…”

Section: Introductionmentioning

confidence: 98%

The effect of sanitary landfill leachate aging on the biological treatment and assessment of photoelectrooxidation as a pre-treatment process

et al. 2015

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Effect of landfill leachate on oxidative stress of brain structures and liver from rodents: Modulation by photoelectrooxidation process

Cited by 17 publications

References 60 publications

Genotoxic effects of old landfill leachate on HepG2 cells after nitration/ultrafiltration/reverse osmosis membrane treatment process

Genotoxic effects of old landfill leachate on HepG2 cells after nitration/ultrafiltration/reverse osmosis membrane treatment process

Efectos del estrés sobre los procesos de plasticidad y neurogénesis: una revisión

The effect of sanitary landfill leachate aging on the biological treatment and assessment of photoelectrooxidation as a pre-treatment process

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