Effect of Lactobacillus salivarius Ls-33 on fecal microbiota in obese adolescents

Larsen, Niels‐Erik; Vogensen, Finn K.; Gøbel, Rikke Juul; Michaelsen, Kim F.; Forssten, Sofia D.; Lahtinen, Sampo J.; Jakobsen, Mogens

doi:10.1016/j.clnu.2013.02.007

Cited by 94 publications

(67 citation statements)

References 27 publications

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“…Intake of Lactobacillus casei Shirota for 3 months did not positively affect the metabolic syndrome parameters in adults (Leber et al, 2012) and intake of Lactobacillus salivarius Ls-33 did not confer any beneficial effects on metabolic syndrome in obese adolescents (Gobel, Larsen, Jakobsen, Molgaard, & Michaelsen, 2012). In the latter study there was an altered faecal microbiota composition but could however not be linked to the metabolic syndrome (Larsen et al, 2013). Kim et al (2013) used 6 commercial probiotic strains to investigate the response of gut microbiota in healthy adults and found that regardless of the probiotic strain used, the intervention did not affect the overall structure of the microbiota.…”

Section: Discussionmentioning

confidence: 98%

Oral and faecal microbiota in volunteers with hypertension in a double blind, randomised placebo controlled trial with probiotics and fermented bilberries

Ahrén

Olsson

et al. 2015

Journal of Functional Foods

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Section: Discussionmentioning

confidence: 98%

Oral and faecal microbiota in volunteers with hypertension in a double blind, randomised placebo controlled trial with probiotics and fermented bilberries

Ahrén

Olsson

et al. 2015

Journal of Functional Foods

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“…SMCC ZAT352 were found to be associated with adipogenesis. For example, P. frisingensis synthesizes lipopolysaccharide with polymeric O-specific chains that are related to host obesity [32], L. salivarius can modify the fecal microbiota, which in turn affects metabolic pathways in obese chickens and humans [33, 34], and Micrococcus is involved in lipolytic activity, which shows a positive correlation with fatty acid biosynthesis [35]. Although 16S rDNA amplicon sequencing was the primary method used to analyze microbial diversity, we also used the computation tool PICRUSTs [36] to predict microbial community functions [see Additional file 7].…”

Section: Discussionmentioning

confidence: 99%

Divergent selection-induced obesity alters the composition and functional pathways of chicken gut microbiota

et al. 2016

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BackgroundThe gastrointestinal tract is populated by a complex and vast microbial network, with a composition that reflects the relationships of the symbiosis, co-metabolism, and co-evolution of these microorganisms with their host. The mechanism that underlies such interactions between the genetics of the host and gut microbiota remains elusive.ResultsTo understand how genetic variation of the host shapes the gut microbiota and interacts with it to affect the metabolic phenotype of the host, we compared the abundance of microbial taxa and their functional performance between two lines of chickens (fat and lean) that had undergone long-term divergent selection for abdominal fat pad weight, which resulted in a 4.5-fold increase in the fat line compared to the lean line. Our analysis revealed that the proportions of Fusobacteria and Proteobacteria differed significantly between the two lines (8 vs. 18% and 33 vs. 24%, respectively) at the phylum level. Eight bacterial genera and 11 species were also substantially influenced by the host genotype. Differences between the two lines in the frequency of host alleles at loci that influence accumulation of abdominal fat were associated with differences in the abundance and composition of the gut microbiota. Moreover, microbial genome functional analysis showed that the gut microbiota was involved in pathways that are associated with fat metabolism such as lipid and glycan biosynthesis, as well as amino acid and energy metabolism. Interestingly, citrate cycle and peroxisome proliferator activated receptor (PPAR) signaling pathways that play important roles in lipid storage and metabolism were more prevalent in the fat line than in the lean line.ConclusionsOur study demonstrates that long-term divergent selection not only alters the composition of the gut microbiota, but also influences its functional performance by enriching its relative abundance in microbial taxa. These results support the hypothesis that the host and gut microbiota interact at the genetic level and that these interactions result in their co-evolution.Electronic supplementary materialThe online version of this article (doi:10.1186/s12711-016-0270-5) contains supplementary material, which is available to authorized users.

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“…In a study by Larsen et al . () with obese adolescents, the researchers found that administration of L. salivarius Ls‐33 might modify the faecal microbiota in the cohort in a way not related to metabolic syndrome, a condition typically associated with the population under study. The ratio of Bacteroides / Prevotella / Porphyromonas group to Firmicutes‐ belonging bacteria, including Clostridium , was significantly increased after administration of Ls‐33.…”

Section: Lactobacillus Salivarius Applications In Human Healthmentioning

confidence: 99%

Applications and safety considerations ofLactobacillus salivariusas a probiotic in animal and human health

2017

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SummaryThe goals of this review are to summarize the current knowledge on the application of Lactobacillus salivarius as a probiotic in animals and humans, and to address safety concerns with its use on live hosts. Overall, several strains of L. salivarius are well established probiotics with multiple applications in animal health, particularly to reduce colonization by gastrointestinal pathogens, and to a lesser extent, as a production and quality aid. In humans, L. salivarius has been used to prevent and treat a variety of chronic diseases, including asthma, cancer, atopic dermatitis and halitosis, and to a much limited extent, to prevent or treat infections. Based on the results from primary research evidence, it seems that L. salivarius does not pose a health risk to animals or humans in the doses currently used for a variety of applications; however, there is a systematic lack of studies assuring the safety of many of the strains intended for clinical use. This review provides researchers in the field with up-to-date information regarding applications and safety of L. salivarius. Furthermore, it helps researchers identify knowledge gaps and potential opportunities for microbiological and clinical research.

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Effect of Lactobacillus salivarius Ls-33 on fecal microbiota in obese adolescents

Cited by 94 publications

References 27 publications

Oral and faecal microbiota in volunteers with hypertension in a double blind, randomised placebo controlled trial with probiotics and fermented bilberries

Oral and faecal microbiota in volunteers with hypertension in a double blind, randomised placebo controlled trial with probiotics and fermented bilberries

Divergent selection-induced obesity alters the composition and functional pathways of chicken gut microbiota

Applications and safety considerations ofLactobacillus salivariusas a probiotic in animal and human health

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