Applications and safety considerations ofLactobacillus salivariusas a probiotic in animal and human health

Abstract

SummaryThe goals of this review are to summarize the current knowledge on the application of Lactobacillus salivarius as a probiotic in animals and humans, and to address safety concerns with its use on live hosts. Overall, several strains of L. salivarius are well established probiotics with multiple applications in animal health, particularly to reduce colonization by gastrointestinal pathogens, and to a lesser extent, as a production and quality aid. In humans, L. salivarius has been used to prevent and treat a variety of chronic diseases, including asthma, cancer, atopic dermatitis and halitosis, and to a much limited extent, to prevent or treat infections. Based on the results from primary research evidence, it seems that L. salivarius does not pose a health risk to animals or humans in the doses currently used for a variety of applications; however, there is a systematic lack of studies assuring the safety of many of the strains intended for clinical use. This review provides researchers in the field with up-to-date information regarding applications and safety of L. salivarius. Furthermore, it helps researchers identify knowledge gaps and potential opportunities for microbiological and clinical research.

Effect of Ligilactobacillus salivarius and Other Natural Components against Anaerobic Periodontal Bacteria

“…Tooth disease can be specified as a result of refraction or change of bacterial homeostasis. The oral epithelium is one of the physical mechanisms preventing the colonization of the oral cavity by hostile microorganisms and biofilm formation [ 1 , 2 , 3 , 4 , 5 ]. The biofilm of microorganisms themselves produce substances that inhibit other bacteria growth.…”

“…The biofilm of microorganisms themselves produce substances that inhibit other bacteria growth. The ability of some bacteria to adhere to the epithelium and teeth is one of the main factors determining the bacterial composition of the mouth [ 1 , 2 , 3 , 4 , 5 , 6 ]. The bacterial flora of the mouth has developed over the centuries to create a stable ecosystem.…”

“…According to the recent data there is over 700–1000 bacteria species that may colonize the human oral cavity like Treponema, Lactobacillus, Propionibacterium , Selenomonas and others [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. They can cause apoplexy, common warts, shingles and smallpox [ 5 , 7 , 16 , 17 , 18 ].…”

An orally administered oral pathobiont and commensal have comparable and innocuous systemic effects in germ‐free mice

“…gingivalis on the gene expression profile in various tissues was investigated in germ‐free mice. Lactobacillus salivarius , an oral commensal with probiotic characteristics, was used as a control.…”

Selection of Lactobacillus strains newly isolated from Algerian camel and mare fermented milk for their in vitro probiotic and lipolytic potentials

“…It is well known that non-hemolytic bacteria are part of the microorganism group Generally Recorganized as Safe (GRAS), which is the case of LAB. Lactobacilli strains do not pose a health risk to animals or humans (Rychen et al, 2017;Olek et al, 2017;Chaves et al, 2017).…”