Effect of Lactobacillus johnsonii La1 on immune function and serum albumin in aged and malnourished aged mice

Kaburagi, Tomoko; Yamano, Toshìo; Fukushima, Yoichi; Yoshino, Haruka; Mito, Natsuko; Sato, Kazuto

doi:10.1016/j.nut.2007.02.001

Cited by 64 publications

(37 citation statements)

References 34 publications

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“…Probiotics are able to stimulate the immunological system (Erickson and Hubbard 2000, Cano and Perdigón 2003, Copolla and Gil Turnes 2004, Villena et al 2006, De Souza et al 2007, Dewan et al 2007, kaburagi et al 2007, Pitsouni et al 2009) it is suggested that the deficit prevention in the tissue formation of the mucosa due to malnourishment be balanced because of the proliferation of conjunctive tissue cells (the lamina propria), which explains the results observed in animals of G4. Besides, the height G1: commercial chow for rodents; G2: commercial chow + supplementation with probiotics; G3: chow with 4% proteins; G4: chow with 4% proteins + supplementation with probiotics.…”

Section: Resultsmentioning

confidence: 99%

“…These findings ratify the beneficial effect of the intake of these microorganisms, including in cases when the amount of proteins present in the provided diet does not meet the demand of the involved organism. Possibly, the increase of the intestinal barrier efficiency (Menningen and Bruewer 2009) and the stimulation of the immunological system (Erickson and Hubbard 2000, Cano and Perdigón 2003, Copolla and Turnes 2004, Villena et al 2006, De Souza et al 2007, Dewan et al 2007, kaburagi et al 2007, Pitsouni et al 2009) promoted by the action of probiotics must have collaborated to a higher absorption of available aminoacids in the hypoproteic feed. Studies on this hypothesis can corroborate future investigations that aim to optimize the access to functional foods or supplements containing probiotics in cases of malnourishment in humans.…”

Section: Height Of Enterocytesmentioning

confidence: 99%

“…Several studies have demonstrated that probiotics estimulate cell proliferation of the immune system associated to the intestinal mucosa (Erickson and Hubbard 2000, Cano and Perdigón 2003, Villena et al 2006, De Souza et al 2007, Dewan et al 2007, kaburagi et al 2007, Pitsouni et al 2009), which may contribute to the control of infections, as well as to their prevention in the case of diseases derived from nutritional deficiency. On the other hand, there are few studies that evaluated the action of probiotics on the intestinal morphology of malnourished animals, and were mostly restricted only to the study of the mucosa (Allori et al 2000, Cano et al 2002, Dock et al 2004a, b, Dock-Nascimento et al 2007.…”

Section: Introductionmentioning

confidence: 99%

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Probiotics prevent growth deficit of colon wall strata of malnourished rats post-lactation

Lima

Azevedo

Hermes-Uliana

et al. 2012

An. Acad. Bras. Ciênc.

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The objective of this study was to analyze morphometrically the colon wall strata of malnourished rats supplemented with probiotics. Sixteen recently weaned Wistar rats (Rattus norvegicus) were distributed into four groups: animals that received commercial chow (G1, n = 4); animals that received the same feed as G1 and were supplemented with probiotics (G2, n = 4); animals that received chow with 4% of proteins (G3, n = 4); animals that received the same feed as G3 and were supplemented with probiotics (G4, n = 4). After 12 weeks, the proximal colon was collected and submitted to histological processing. Three-µm cuts were stained with H.E., Periodic Acid Schifff (P.A.S.) + diasthasis solution and Alcian Blue (A.B.) pH 2.5 and pH 1.0. The morphometric analysis of the intestinal wall showed that the supplementation with ABT-4 probiotic culture prevents the growth deficit of colon wall strata that normally occurs in malnourished rats right after lactation. Besides, no alteration was observed in the proportion of the number of globet cells in relation to the number of enterocytes in malnourished rats, regardless of the supplementation with probiotics.

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Section: Resultsmentioning

confidence: 99%

Section: Height Of Enterocytesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Probiotics prevent growth deficit of colon wall strata of malnourished rats post-lactation

Lima

Azevedo

Hermes-Uliana

et al. 2012

An. Acad. Bras. Ciênc.

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“…Lactobacillus johnsonii has been exfensively sfudied for its clinical and nutritional health benefits (Kaburagi et al, 2007). Reports have shown that L. johnsonii has beneficial effects such as immunomodulation and pathogen inhibition (Pridmore et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Orally administered ovine serum immunoglobulins modulate the intestinal levels of Lactobacillus and enterobacteria in the growing rat1

Balan

Han

Lawley

et al. 2013

Journal of Animal Science

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The aim was to determine whether orally administered ovine serum immunoglobulins modulate the gut microbiota in the growing rat. Thirty Sprague-Dawley male rats were used in a 21-d study and fed either a basal control diet (control; no immunoglobulin) or a similar diet containing freeze-dried ovine immunoglobulin (ovine Ig) with 15 individually fed rats per diet. Bacterial DNA isolated from ileal and colonic digesta were subjected to PCR-denaturing gradient gel electrophoresis (PCR-DGGE). In the ileum, the DGGE band number and diversity index were greater (P < 0.05) for rats fed the ovine Ig than those fed the control diet. The DNA sequencing of a selected DGGE band in the ovine Ig-fed rats revealed 99% similarity to the Lactobacillus strains. The quantitative PCR data revealed that supplementation of the diet with the ovine Ig fraction supported the growth of Lactobacillus and conversely decreased the number of enterobacteria in ileal and colonic digesta. Inclusion of the ovine Ig fraction led to a greater (P < 0.05) ratio for total Lactobacillus to total bacteria and total Lactobacillus to enterobacteria. The results from the present study show that dietary supplementation with ovine Ig may alter the intestinal environment by a specific enrichment of Lactobacillus strains and depletion of enterobacteria.

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“…However, several zootechnical studies have reported controversial results regarding digestibility and increases in body mass in animals used for human consumption (Kamra et al 1996, De Brito et al 2005, Sanches et al 2006, Budiño et al 2006, Huaynate et al 2006, Zanato et al 2008. Additionally, several studies have shown that probiotics stimulate the immune system (Erickson and Hubbard 2000, Cano and Perdigón 2003, Villena et al 2006, De Souza et al 2007, Dewan et al 2007, Kaburagi et al 2007, Pitsouni et al 2009), which could contribute to prevention or even treatment of bowel infection, which is another problem to consider in cases of malnutrition associated with anatomical and functional bowel disorders (Chandra 1992). In addition, other studies suggest that probiotics might contribute to the integrity of the intestinal barrier (Menningen and Bruewer 2009) and that they are efficacious in treating inflammatory bowel diseases (Resta-Lenert and Barrett 2009).…”

mentioning

confidence: 99%

Probiotics protect the intestinal wall of morphological changes caused by malnutrition

Azevedo

Hermes-Uliana

Lima

et al. 2014

An. Acad. Bras. Ciênc.

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This study sought to morphometrically analyze the jejunal wall of protein-malnourished rats administered a probiotic supplement. The sample consisted of recently weaned Wistar rats (Rattus norvegicus) distributed among four groups: animals given a commercial diet (G1, n = 4); animals given the same ration as G1 plus a probiotic supplement (G2, n = 4); animals given a 4% protein diet (G3, n = 4); and animals given the same ration as G3 plus a probiotic supplement (G4, n = 4). After 12 weeks, part of the jejunum was harvested and subjected to routine histological processing. Transverse sections with a thickness of 3 µm were stained with HE, and histochemical techniques were used to assay for glycoconjugates, including staining with periodic acid-Schiff (PAS) + diastase, Alcian Blue (AB) solution at pH 2.5, and Alcian Blue solution at pH 1.0. Morphometric analysis of the bowel wall showed that the probiotic culture used in this study induced hypertrophy of several layers of the jejunal wall in well-nourished animals and reduced the bowel wall atrophy usually observed in protein-malnourished animals. Neither malnutrition nor the use of probiotics altered the relationship between the number of goblet cells and the number of enterocytes.

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Effect of Lactobacillus johnsonii La1 on immune function and serum albumin in aged and malnourished aged mice

Cited by 64 publications

References 34 publications

Probiotics prevent growth deficit of colon wall strata of malnourished rats post-lactation

Probiotics prevent growth deficit of colon wall strata of malnourished rats post-lactation

Orally administered ovine serum immunoglobulins modulate the intestinal levels of Lactobacillus and enterobacteria in the growing rat1

Probiotics protect the intestinal wall of morphological changes caused by malnutrition

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