Effect of Lactobacillus casei on lipid metabolism and intestinal microflora in patients with alcoholic liver injury

Li, Xuelong; Liu, Ying; Guo, Xiaofei; Ma, Yan; Zhang, Huaqi; Liang, Hui

doi:10.1038/s41430-020-00852-8

Cited by 39 publications

(31 citation statements)

References 37 publications

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“…Other randomized-controlled trials of Lactobacillus casei supplements in patients with alcoholic liver injury support this finding. 111 In general, the mechanisms by which probiotics prevent chronic liver injury include: reducing gut-derived microbial LPS by restoring the bowel flora, repairing the intestinal mucosa and barrier function, modulation of the immune system, and reducing inflammatory cytokine levels. 112…”

Section: Probioticsmentioning

confidence: 99%

The Role of Gut-Derived Lipopolysaccharides and the Intestinal Barrier in Fatty Liver Diseases

Wirth

Koch

et al. 2022

Journal of Gastrointestinal Surgery

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Background Hepatosteatosis is the earliest stage in the pathogenesis of nonalcoholic fatty (NAFLD) and alcoholic liver disease (ALD). As NAFLD is affecting 10–24% of the general population and approximately 70% of obese patients, it carries a large economic burden and is becoming a major reason for liver transplantation worldwide. ALD is a major cause of morbidity and mortality causing 50% of liver cirrhosis and 10% of liver cancer related death. Increasing evidence has accumulated that gut-derived factors play a crucial role in the development and progression of chronic liver diseases. Methods A selective literature search was conducted in Medline and PubMed, using the terms “nonalcoholic fatty liver disease,” “alcoholic liver disease,” “lipopolysaccharide,” “gut barrier,” and “microbiome.” Results Gut dysbiosis and gut barrier dysfunction both contribute to chronic liver disease by abnormal regulation of the gut-liver axis. Thereby, gut-derived lipopolysaccharides (LPS) are a key factor in inducing the inflammatory response of liver tissue. The review further underlines that endotoxemia is observed in both NAFLD and ALD patients. LPS plays an important role in conducting liver damage through the LPS-TLR4 signaling pathway. Treatments targeting the gut microbiome and the gut barrier such as fecal microbiota transplantation (FMT), probiotics, prebiotics, synbiotics, and intestinal alkaline phosphatase (IAP) represent potential treatment modalities for NAFLD and ALD. Conclusions The gut-liver axis plays an important role in the development of liver disease. Treatments targeting the gut microbiome and the gut barrier have shown beneficial effects in attenuating liver inflammation and need to be further investigated.

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Section: Probioticsmentioning

confidence: 99%

The Role of Gut-Derived Lipopolysaccharides and the Intestinal Barrier in Fatty Liver Diseases

Wirth

Koch

et al. 2022

Journal of Gastrointestinal Surgery

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“…Furthermore, even heat-killed strains and breaking solutions can ameliorate ALD [ 19 , 20 ]. Numerous studies have reported that probiotics can attenuate alcoholic liver damaged mainly via improving lipid metabolism [ 21 ], reducing TNF- α [ 22 ], IL-6 [ 23 ], and IL-1 β [ 24 ], and ameliorating oxidative stress [ 25 ]. Reducing oxidative stress includes reducing MDA levels, increasing SOD activity [ 23 ], and regulating the keep-Nrf2-ARE signaling pathway [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidative and Anti‐Inflammatory Effects of Lactobacillus plantarum ZS62 on Alcohol‐Induced Subacute Hepatic Damage

Gan

Chen

2021

Oxidative Medicine and Cellular Longevity

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Lactobacillus plantarum ZS62 is a newly isolated strain from naturally fermented yogurt that might offer some beneficial effects in the setting of alcohol-induced subacute liver injury. The liver-protective effect of L. plantarum ZS62 was investigated by gavage feeding of mice with this Lactobacillus strain ( 1 × 10 9 CFU/kg BW) before alcohol administration daily for 7 days. We then compared hepatic morphology, liver function indexes, liver lipid levels, inflammation, oxidative stress levels, and mRNA expression of oxidative metabolism- and inflammation-related genes in mice that had been pretreated with Lactobacillus plantarum versus control mice that had not been pretreated. Our results showed that L. plantarum ZS62 attenuated alcohol-induced weight loss; prevented morphological changes in hepatocytes; reduced markers of liver damage including aspartate aminotransaminase (AST), alanine aminotransaminase (ALT), hyaluronidase (HAase), precollagen III (PC III), and inflammatory cytokines; and enhanced the antioxidative status. L. plantarum ZS62 also significantly downregulated inflammation-related genes and upregulated lipid- and oxidative-metabolism genes. Thus, Lactobacillus plantarum pretreatment appears to confer hepatic protection by reducing inflammation and enhancing antioxidative capacity. The protective effect of L. plantarum ZS62 was even better than that of a commonly used commercial lactic acid bacteria (Lactobacillus delbrueckii subsp. Bulgaricus). The L. plantarum ZS62 might be a potentially beneficial prophylactic treatment for people who frequently drink alcoholic beverages.

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“…In human study, supplementation of patients with alcoholic liver injury with L. casei significantly decreased their serum TG and LDL-C. The amounts of Lactobacillus and Bifidobacterium were increased compared to those in the control group; consequently, gut microbiota disorders were controlled, and lipid metabolism was improved [94]. Many studies have shown that Lactobacillus improves ALD.…”

Section: Alcoholic Liver Diseasementioning

confidence: 95%

The Lactobacillus as a Probiotic: Focusing on Liver Diseases

Jeong¹,

Park²,

Gi³

et al. 2022

Microorganisms

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Over the past decade, scientific evidence for the properties, functions, and beneficial effects of probiotics for humans has continued to accumulate. Interest in the use of probiotics for humans has increased tremendously. Among various microorganisms, probiotics using bacteria have been widely studied and commercialized, and, among them, Lactobacillus is representative. This genus contains about 300 species of bacteria (recently differentiated into 23 genera) and countless strains have been reported. They improved a wide range of diseases including liver disease, gastrointestinal diseases, respiratory diseases, and autoimmune diseases. Here, we intend to discuss in depth the genus Lactobacillus as a representative probiotic for chronic liver diseases.

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Effect of Lactobacillus casei on lipid metabolism and intestinal microflora in patients with alcoholic liver injury

Cited by 39 publications

References 37 publications

The Role of Gut-Derived Lipopolysaccharides and the Intestinal Barrier in Fatty Liver Diseases

The Role of Gut-Derived Lipopolysaccharides and the Intestinal Barrier in Fatty Liver Diseases

Antioxidative and Anti‐Inflammatory Effects of Lactobacillus plantarum ZS62 on Alcohol‐Induced Subacute Hepatic Damage

The Lactobacillus as a Probiotic: Focusing on Liver Diseases

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