Effect of L-thyroxine replacement on apolipoprotein B-48 in overt and subclinical hypothyroid patients

M, Ito; Kitanaka, Akira; Arishima, Takeshi; Kudo, Takumi; Nishihara, Eijun; Kubota, Sumihisa; Amino, Nobuyuki; Hiraiwa, Tomoko; Hanafusa, Toshiaki; Miyauchi, Akira

doi:10.1507/endocrj.ej12-0226

Cited by 17 publications

(12 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, an older study showed that SH affects resting energy expenditure, although its effect on body composition was insignificant (16). In general, restoration of thyroid function does not seem to have any significant effect on BMI, in patients with SH (17)(18)(19). However, a randomised controlled prospective study, evaluating the effect of L-T4 on somatometric parameters, did show a reduction in body weight, although slight (mean decrease of 0.6 kg after intervention) in patients with mean baseline TSH levels of 5.4 mIU/l, after 3 months.…”

Section: Discussionmentioning

confidence: 99%

The effect of L-thyroxine substitution on lipid profile, glucose homeostasis, inflammation and coagulation in patients with subclinical hypothyroidism

et al. 2014

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

The effect of L-thyroxine substitution on lipid profile, glucose homeostasis, inflammation and coagulation in patients with subclinical hypothyroidism

et al. 2014

View full text Add to dashboard Cite

show abstract

“…15,17 Other results showed that levothyroxine treatment significantly reduced TC, non-HDL-C, remnant-like particle (RLP)-C and apoB levels in SCH patients but not LDL-C, although normalization of serum TSH had been achieved. 65,66 On the other hand, there are also several studies demonstrating no significant benefit in lipid profile in patients with SCH receiving levothyroxine treatment.…”

Section: Effect Of Levothyroxine Treatmentmentioning

confidence: 99%

“…As far as HDL-C is concerned, most studies demonstrate no significant effect of levothyroxine substitution on HDL-C concentrations in SCH. 16,18,20,24,47,[60][61][62][63][65][66][67]69,70 Nevertheless, there is limited evidence suggesting either a lowering 15,17,59,72 or an increasing effect.…”

Section: Effect Of Levothyroxine Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Subclinical hypothyroidism and vascular risk: Αn update

Lioudaki¹,

Mavroeidi²,

Mikhailidis³

et al. 2013

View full text Add to dashboard Cite

subclinical hypothyroidism (scH), defined as elevated serum thyroid-stimulating hormone (tsH) in the presence of normal circulating free thyroxine (Ft4) and triiodothyronine (t3), is a relatively common condition. replacement treatment with levothyroxine is justified only for individuals with tsH levels >10 mIU/l. serum lipid levels are influenced by thyroid status and there is evidence pointing to a link between scH and an unfavorable lipid profile. Despite some conflicting data, most studies suggest that levothyroxine treatment may exert a beneficial effect on the lipid profile in scH regarding mainly total cholesterol and low-density lipoproteincholesterol. Moreover, it appears that treatment may also improve some other markers associated with cardiovascular (cV) disease such as carotid intima media thickness ( 17-03-201317-03- , Accepted 20-10-2013 Review (FT4) and triiodothyronine (T3) levels within the reference range.1 This is a relatively common condition with a prevalence ranging from 4 to 15% in the general population and up to 20% among females aged >60 years. [2][3][4][5]

show abstract

“…Our previous studies have demonstrated that high-fat feeding dramatically increases the concentration of TSH in the serum, and lipotoxicity may participate in thyroid dysfunction [12] . Many studies on the influence of thyroxine replacement therapy on the blood lipid characteristics of SH patients are controversial [4,13,14] . Lipolysis is one of the key steps in lipid metabolism.…”

Section: Wwwchinapharcom Zhang Y Et Almentioning

confidence: 99%

Thyroxine therapy ameliorates serum levels of eicosanoids in Chinese subclinical hypothyroidism patients

Zhang

et al. 2016

Acta Pharmacol Sin

View full text Add to dashboard Cite

Aim: The eicosanoids derived from phospholipids play key roles in inflammation. However, the profiles of serum eicosanoids in subclinical hypothyroidism (SH) patients and the effects of thyroxine replacement therapy (TRT) on these eicosanoids remain unclear. Many studies show that TSH regulates lipid metabolism. As eicosanoids derived from phospholipids play key roles in oxidative stress and immune function and inflammatory process, it was necessary to explore the profiles of serum eicosanoids in SH patients and the effects of thyroxine replacement therapy (TRT) on the eicosanoids. Methods: A total of 50 Chinese SH patients and 22 healthy volunteers were recruited. SH patients received TRT (L-T4, 25 and 50 mcg/d for patients with TSH≤10.0 mIU/L and TSH>10.0 mIU/L, respectively) for 3 months. Serum levels of major eicosanoids and cPLA2 were analyzed using LC-MS and clinical biochemical assays. Results: The serum levels of cPLA2, eicosanoids (8-isoPGF2a, 11-dehydroTXB2 and 12-HETE) and 11-dehydroTXB2/6-Keto-PGF1a were significantly elevated in SH patients. The serum TSH levels were significantly correlated with the levels of cPLA2 (r=+0.65), 11-dehydroTXB2 (r=+0.32) and 11-dehydroTXB2/6-Keto-PGF1a (r=+0.37). After 3-month TRT, the serum levels of TSH, cPLA2 and the above-mentioned eicosanoids in SH patients were significantly decreased. Conclusion: The metabolism of eicosanoids is significantly altered in Chinese SH patients, and TRT can ameliorate the abnormalities of serum eicosanoid levels.

show abstract

Effect of L-thyroxine replacement on apolipoprotein B-48 in overt and subclinical hypothyroid patients

Cited by 17 publications

References 37 publications

The effect of L-thyroxine substitution on lipid profile, glucose homeostasis, inflammation and coagulation in patients with subclinical hypothyroidism

The effect of L-thyroxine substitution on lipid profile, glucose homeostasis, inflammation and coagulation in patients with subclinical hypothyroidism

Subclinical hypothyroidism and vascular risk: Αn update

Thyroxine therapy ameliorates serum levels of eicosanoids in Chinese subclinical hypothyroidism patients

Contact Info

Product

Resources

About