Thyroxine therapy ameliorates serum levels of eicosanoids in Chinese subclinical hypothyroidism patients

Abstract

Aim: The eicosanoids derived from phospholipids play key roles in inflammation. However, the profiles of serum eicosanoids in subclinical hypothyroidism (SH) patients and the effects of thyroxine replacement therapy (TRT) on these eicosanoids remain unclear. Many studies show that TSH regulates lipid metabolism. As eicosanoids derived from phospholipids play key roles in oxidative stress and immune function and inflammatory process, it was necessary to explore the profiles of serum eicosanoids in SH patients and the effects of thyroxine replacement therapy (TRT) on the eicosanoids. Methods: A total of 50 Chinese SH patients and 22 healthy volunteers were recruited. SH patients received TRT (L-T4, 25 and 50 mcg/d for patients with TSH≤10.0 mIU/L and TSH>10.0 mIU/L, respectively) for 3 months. Serum levels of major eicosanoids and cPLA2 were analyzed using LC-MS and clinical biochemical assays. Results: The serum levels of cPLA2, eicosanoids (8-isoPGF2a, 11-dehydroTXB2 and 12-HETE) and 11-dehydroTXB2/6-Keto-PGF1a were significantly elevated in SH patients. The serum TSH levels were significantly correlated with the levels of cPLA2 (r=+0.65), 11-dehydroTXB2 (r=+0.32) and 11-dehydroTXB2/6-Keto-PGF1a (r=+0.37). After 3-month TRT, the serum levels of TSH, cPLA2 and the above-mentioned eicosanoids in SH patients were significantly decreased. Conclusion: The metabolism of eicosanoids is significantly altered in Chinese SH patients, and TRT can ameliorate the abnormalities of serum eicosanoid levels.

Two new species of Ganoderma (Ganodermataceae, Basidiomycota) from Southwest China

“…Xing & Y.F. Sun ( Zhao et al 1983 ; Cao et al 2012; Li et al 2015 ; Hapuarachchi et al 2019 ; He et al 2021 ; He et al 2022 ; Sun et al 2022 ; Yang et al 2022 ). During the last five years, the diversity of Ganoderma in Southwest China was mainly reported from Yunnan Province and Guizhou Province ( Hapuarachchi et al 2019 ; Luangharn et al 2021 ; He et al 2022 ; Sun et al 2022 ).…”

Dor facial crônica e sua associação com morbidades odontológicas e sistêmicas

“…Em seguida, ocorre catalisação da hidrólise fosfolipídea, resultando em ácidos graxos (como o ácido araquidônico). Os eicosanoides derivados do ácido araquidônico incluem as prostaglandinas e têm papel no estresse oxidativo e na função imunoinflamatória (Zhang, Zhang et al, 2016). O tratamento do hipotireoidismo baseia-se na reposição hormonal (Craig e Stitzel, 2004).…”

“…A correlação entre doenças endocrinometabólicas e a dor facial pode relacionarse aos papéis neurotrófico e inflamatório dos hormônios envolvidos (Craig e Stitzel, 2004;Zhang, Zhang et al, 2016). As alterações sensitivas nos doentes com morbidades cardiovasculares já foi descrita na literatura, estando relacionada à sensibilização de mecanoceptores e alteração na expressão de canais de sódio (Chapleau, Li et al, 2001;Viggiano, Zagaria et al, 2009;Schubert, Fischer et al, 2016 …”