Effect of L-arginine on HSP70 expression in liver in weanling piglets

Wu, Xin; Xie, Changqing; Yin, Yulong; Li, Fengna; Li, Tiejun; Huang, Ruilin; Ruan, Zheng; Deng, Zeyuan

doi:10.1186/1746-6148-9-63

Cited by 31 publications

(15 citation statements)

References 32 publications

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“…This result may indicate the cytoprotective beneficial impact of these agents against hypoxia induced renal tissue injury. There is an evidence that carnosine and arginine can regulate intracellular HSP-70 expression which is essential for preventing organ dysfunction (Chatterjee et al 2005;Mikami et al 2006;Wu et al 2013) . The current result also revealed that a marked elevation in the serum HIF-1α of hypoxic rats compared with normal animals.…”

Section: Discussionmentioning

confidence: 99%

Regulating Effect Of Carnosine And /Or L- Arginine On The Expression Of Inflammatory Molecules Induced Nephropathy In The Hypoxic Rat Model

Al-Rasheed

Fadda

Mohamed

et al. 2016

Braz. arch. biol. technol.

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This study aimed to explore the effective role of carnosine and /or L-arginine pro-inflammatory molecules, including tumor necrosis factor-α (TNF-α) , Creactive protein (CRP), vascular endothelial growth factor (VEGF) and heat shock protein -70 (HSP-70) as well as interleukin-6 (IL-6) in renal tissue compared to NaNO2 hypoxic rats . Also, the two agents successfully down modulated the alteration in the serum hypoxia inducible factor 1α (HIF 1α

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Section: Discussionmentioning

confidence: 99%

Regulating Effect Of Carnosine And /Or L- Arginine On The Expression Of Inflammatory Molecules Induced Nephropathy In The Hypoxic Rat Model

Al-Rasheed

Fadda

Mohamed

et al. 2016

Braz. arch. biol. technol.

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“…In conclusion, treatment of pigs with mold-contaminated feed has adverse effects on growth performance, structure of the intestine (histology, morphology and barrier function), and serum amino acid profile. Glutamate likes other functional amino acids can improve animal health [60] – [77] . Dietary supplementation with glutamate partially counteracts the impairments induced by mycotoxins.…”

Section: Discussionmentioning

confidence: 99%

Dietary Glutamate Supplementation Ameliorates Mycotoxin-Induced Abnormalities in the Intestinal Structure and Expression of Amino Acid Transporters in Young Pigs

Duan

Yin

et al. 2014

PLoS ONE

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The purpose of this study was to investigate the hypothesis that dietary supplementation with glutamic acid has beneficial effects on growth performance, antioxidant system, intestinal morphology, serum amino acid profile and the gene expression of intestinal amino acid transporters in growing swine fed mold-contaminated feed. Fifteen pigs (Landrace×Large White) with a mean body weight (BW) of 55 kg were randomly divided into control group (basal feed), mycotoxin group (contaminated feed) and glutamate group (2% glutamate+contaminated feed). Compared with control group, mold-contaminated feed decreased average daily gain (ADG) and increased feed conversion rate (FCR). Meanwhile, fed mold-contaminated feed impaired anti-oxidative system and intestinal morphology, as well as modified the serum amino acid profile in growing pigs. However, supplementation with glutamate exhibited potential positive effects on growth performance of pigs fed mold-contaminated feed, ameliorated the imbalance antioxidant system and abnormalities of intestinal structure caused by mycotoxins. In addition, dietary glutamate supplementation to some extent restored changed serum amino acid profile caused by mold-contaminated feed. In conclusion, glutamic acid may be act as a nutritional regulating factor to ameliorate the adverse effects induced by mycotoxins.

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“…Western blotting were performed as described previously [17]. The membranes were incubated with primary antibodies, including total mTOR (#2972; Cell Signaling Technology), p-mTOR (#5536; Cell Signaling Technology), p-4EBP1 (#9451; Cell Signaling Technology), p-p70S6K (ab126818; Abcam) and β-actin (sc-47778; Santa Cruz) antibodys at 1:1000 dilution.…”

Section: Methodsmentioning

confidence: 99%

Chitosan oligosaccharide affects antioxidant defense capacity and placental amino acids transport of sows

Xie

Long

et al. 2016

BMC Vet Res

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BackgroundChitosan oligosaccharide (COS) is widely consumed as a functional food due to its multiple health effects, but few studies about COS supplement on placental antioxidant and nutrition transport capacity were reported. Taken pregnant sow as a model, we aimed to investigate the effects of dietary COS supplementation during late gestation on placental amino acids transport and antioxidant defense capacity of sows. From day (d) 85 of gestation to parturition, sixteen pregnant sows were divided into a control group (basal diet without COS supplementation) and a COS group (30 mg COS/kg basal diet). Plasma sample of sow was collected on d 110 of gestation, and placenta tissue was obtained during parturition. Then plasma antioxidant enzyme’s activities, the relative level of oxidant stress related genes, amino acids transport related genes and mTOR pathway molecules in placenta were determined.ResultsResults showed that maternal dietary supplementation with COS increased (P < 0.05) plasma total SOD, caused a downtrend in plasma MDA (0.05 < P < 0.10) on d 110 of gestation. Interestingly, the mRNA expression of some antioxidant genes in the placenta were increased (P < 0.05) and pro-inflammatory cytokines were reduced (P < 0.05) by COS supplement, whereas no significant difference was observed in the activities of placental total SOD and CAT between two groups. Additionally, further study demonstrated that COS feeding stimulated mTOR signaling pathway, increased amino acids transporters expression in placenta.ConclusionsThese observations suggested that COS supplement in sow’s diet during late gestation enhanced antioxidant defense capacity of sows, promoted placental amino acids transport, which may contribute to the health of sows and development of fetus during gestation.

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Effect of L-arginine on HSP70 expression in liver in weanling piglets

Cited by 31 publications

References 32 publications

Regulating Effect Of Carnosine And /Or L- Arginine On The Expression Of Inflammatory Molecules Induced Nephropathy In The Hypoxic Rat Model

Regulating Effect Of Carnosine And /Or L- Arginine On The Expression Of Inflammatory Molecules Induced Nephropathy In The Hypoxic Rat Model

Dietary Glutamate Supplementation Ameliorates Mycotoxin-Induced Abnormalities in the Intestinal Structure and Expression of Amino Acid Transporters in Young Pigs

Chitosan oligosaccharide affects antioxidant defense capacity and placental amino acids transport of sows

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