Effect of kyphoplasty on survival after vertebral compression fractures

Lavelle, William F.; Khaleel, Mohammed A.; Cheney, Robert; Demers, Elizabeth; Carl, Allen L.

doi:10.1016/j.spinee.2007.05.013

Cited by 20 publications

(25 citation statements)

References 24 publications

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“…[9][10][11][12][13][14][15] Mortality after vertebral fractures has been reported to range between 16% and 60% greater than an unaffected population. [15][16][17] In a previous publication, these two morbidity scores provided a control for the medical comorbidities of patients with osteoporosis who sustained vertebral compression fractures treated either surgically or conservatively. 17 We found both instruments to be statistically predictive of survival for the entire patient population.…”

Section: Introductionmentioning

confidence: 99%

“…[15][16][17] In a previous publication, these two morbidity scores provided a control for the medical comorbidities of patients with osteoporosis who sustained vertebral compression fractures treated either surgically or conservatively. 17 We found both instruments to be statistically predictive of survival for the entire patient population. At that time, we did not examine the relationship between the two morbidity scales or whether either score was a better predictor of morbidity in the surgical versus non-operative patient population.…”

Section: Introductionmentioning

confidence: 99%

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Mortality Prediction in a Vertebral Compression Fracture Population: the ASA Physical Status Score versus the Charlson Comorbidity Index

2015

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Background Morbidity and mortality scores are useful to control for medical comorbidities in study populations where either effects of an illness or benefits of a treatment are examined. Our study examined if a direct relationship existed between the American Society of Anesthesiologists Physical Status (ASA) score and the Charlson Comorbidity Index (CCI) in an osteoporosis population where patients had sustained a vertebral compression fracture.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mortality Prediction in a Vertebral Compression Fracture Population: the ASA Physical Status Score versus the Charlson Comorbidity Index

2015

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“…Despite favorable clinical outcomes that might be presumed to confer a survival advantage, there remain little data on mortality among vertebroplasty recipients [26]. In an effort to better define the effect of vertebroplasty on survival in the osteoporotic fracture population, we retrospectively compared the post-procedural mortality of a cohort of vertebroplasty recipients (“treated”) to the mortality of a population-based cohort of Rochester, MN residents with vertebral compression fractures identified between 1985 and 1994 (“untreated”), prior to the introduction of vertebroplasty [27].…”

Section: Introductionmentioning

confidence: 99%

Mortality in the Vertebroplasty Population

McDonald

Achenbach

Atkinson

et al. 2011

AJNR Am J Neuroradiol

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Purpose Vertebroplasty is an effective treatment for painful compression fractures refractory to conservative management. Since there are limited data regarding the survival characteristics of this patient population, we compared the survival of a treated to an untreated vertebral fracture cohort to determine if vertebroplasty affects mortality rates. Materials and Methods The survival of a treated cohort, comprising 524 vertebroplasty recipients with refractory osteoporotic vertebral compression fractures, was compared to a separate, historical cohort of 589 subjects with fractures not treated by vertebroplasty who were identified from the Rochester Epidemiology Project. Mortality was compared between cohorts using Cox proportional hazard models adjusting for age, gender, and Charlson indices of co-morbidity. Mortality was also correlated with pre-, peri-, and post-procedural clinical metrics (e.g., cement volume utilization, Roland-Morris Disability Questionnaire score, analog pain scales, frequency of narcotic use, and improvements in mobility) within the treated cohort. Results Vertebroplasty recipients demonstrated 77% of the survival expected for individuals of similar age, ethnicity, and gender within the US population. When compared to individuals with both symptomatic and asymptomatic untreated vertebral fractures, vertebroplasty recipients retained a 17% greater mortality risk. However, when compared to symptomatic untreated vertebral fractures, vertebroplasty recipients had no increased mortality following adjustment for differences in age, sex and co-morbidity (HR 1.02; CI 0.82–1.25). In addition, no clinical metrics used to assess the efficacy of vertebroplasty were predictive of survival. Conclusion Vertebroplasty recipients have mortality rates similar to individuals with untreated symptomatic fractures but worse mortality compared to those with asymptomatic vertebral fractures.

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“…Vertebroplasty has been used for more than a decade; however, despite favorable clinical outcomes that might be presumed to confer a survival advantage, there are few studies on mortality among patients who undergo this procedure [4,5].…”

Section: Introductionmentioning

confidence: 99%

Can antiosteoporotic therapy reduce mortality in MRI-proved acute osteoporotic vertebral fractures?

Chen

Cheng

et al. 2015

J Bone Miner Metab

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Patients with MRI-proved acute painful vertebral fractures in whom conservative pain management fails are frequently referred for vertebroplasty. This study investigated the effects of treating osteoporosis on the mortality rate of patients with MRI-proved acute osteoporosis-related vertebral fractures who had undergone vertebroplasty. We retrospectively reviewed the cases of osteoporosis patients with MRI-proved acute vertebral fractures who had been treated with vertebroplasty from January 2001 to December 2007. The long-term outcomes of the patients who received antiosteoporotic therapy were compared with those of patients who received no therapy. A total of 304 patients (247 female patients and 57 male patients; mean age, 74.1 ± 7.7 years) were enrolled in the study. The patients who received antiosteoporotic therapy had a significantly lower mortality rate than did patients who did not receive antiosteoporotic therapy (P = 0.001; hazard ratio, 0.396, 95 % confidence interval, 0.273-0.575). At the end of the study, 183 patients were alive, and 121 had died. Effective treatment for osteoporosis may improve survival in patients with osteoporosis-related vertebral fractures after vertebroplasty.

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Effect of kyphoplasty on survival after vertebral compression fractures

Cited by 20 publications

References 24 publications

Mortality Prediction in a Vertebral Compression Fracture Population: the ASA Physical Status Score versus the Charlson Comorbidity Index

Mortality Prediction in a Vertebral Compression Fracture Population: the ASA Physical Status Score versus the Charlson Comorbidity Index

Mortality in the Vertebroplasty Population

Can antiosteoporotic therapy reduce mortality in MRI-proved acute osteoporotic vertebral fractures?

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