Effect of kisspeptin and RFamide-related peptide-3 on the synthesis and secretion of LH by pituitary cells of pigs during the estrous cycle

Zmijewska, Agata; Czelejewska, Wioleta; Dziekoński, Mariusz; Gajewska, Alina; Franczak, Anita; Okrasa, S

doi:10.1016/j.anireprosci.2020.106275

Cited by 10 publications

(10 citation statements)

References 45 publications

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“…RFRP-3 application on GnRH-stimulated cultured pituitary cells was reported to inhibit gonadotropin secretion in Syrian hamsters, 228 sheep, 254 cattle, 255 rats 246 and pigs. 256 However, further studies in rodents, ewes, pigs and horses did not yield any support for a hypophysiotropic effect of RFRP-3. 218,236,245,248,257 Furthermore, although RFRP-3 is detected in the ewe portal blood, its circulating levels show no correlation with LH levels in the peripheral blood.…”

Section: A Disputed Role Of Rfrp-3 In the Seasonal Regulation Of Bree...mentioning

confidence: 90%

“…RFRP‐3 fibers are found in the outer layer of the median eminence, although with various density according to the species and study. RFRP‐3 application on GnRH‐stimulated cultured pituitary cells was reported to inhibit gonadotropin secretion in Syrian hamsters, 228 sheep, 254 cattle, 255 rats 246 and pigs 256 . However, further studies in rodents, ewes, pigs and horses did not yield any support for a hypophysiotropic effect of RFRP‐3 218,236,245,248,257 .…”

Section: A Disputed Role Of Rfrp‐3 In the Seasonal Regulation Of Bree...mentioning

confidence: 98%

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GnRHand the photoperiodic control of seasonal reproduction: Delegating the task to kisspeptin andRFRP‐3

Dardente

Simonneaux

2022

J Neuroendocrinology

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Synchronization of mammalian breeding activity to the annual change of photoperiod and environmental conditions is of the utmost importance for individual survival and species perpetuation. Subsequent to the early 1960s, when the central role of melatonin in this adaptive process was demonstrated, our comprehension of the mechanisms through which light regulates gonadal activity has increased considerably. The current model for the photoperiodic neuroendocrine system points to pivotal roles for the melatonin-sensitive pars tuberalis (PT) and its seasonally-regulated production of thyroid-stimulating hormone (TSH), as well as for TSH-sensitive hypothalamic tan-

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Section: A Disputed Role Of Rfrp-3 In the Seasonal Regulation Of Bree...mentioning

confidence: 90%

Section: A Disputed Role Of Rfrp‐3 In the Seasonal Regulation Of Bree...mentioning

confidence: 98%

GnRHand the photoperiodic control of seasonal reproduction: Delegating the task to kisspeptin andRFRP‐3

Dardente

Simonneaux

2022

J Neuroendocrinology

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“…[ 53 ] reported inhibition of testosterone synthesis by GnIH in avian testicular cell culture. Species such as rats [ 54 ], mice [ 55 ], Syrian hamsters [ 56 ], sheep [ 57 ], pigs [ 58 ], primates [ 59 ], and human [ 55 ] are able to synthesize RFRP-3 in their gonads. The GPR 174 receptors of RFRP-3 have been identified in the oviduct, epididymis, and vas deferens of birds [ 41 ].…”

Section: Functions Of Rfrp-3 In Reproductionmentioning

confidence: 99%

RFamide peptides, the novel regulators of mammalian HPG axis: A review

et al. 2021

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The RFamide-related peptides (RFRPs) are the group of neuropeptides synthesized predominantly from the hypothalamus that negatively affects the hypothalamo-hypophyseal-gonadal (hypothalamic–pituitary–gonadal [HPG]) axis. These peptides are first identified in quail brains and emerged as the mammalian orthologs of avian gonadotropin inhibitory hormones. The RFRP-3 neurons in the hypothalamus are present in several mammalian species. The action of RFRP-3 is mediated through a G-protein-coupled receptor called OT7T022. The predominant role of RFRP-3 is the inhibition of HPG axis with several other effects such as the regulation of metabolic activity, stress regulation, controlling of non-sexual motivated behavior, and sexual photoperiodicity in concert with other neuropeptides such as kisspeptin, neuropeptide-Y (NPY), pro-opiomelanocortin, orexin, and melanin. RFamide peptides synthesized in the granulosa cells, interstitial cells, and seminiferous tubule regulate steroidogenesis and gametogenesis in the gonads. The present review is intended to provide the recent findings that explore the role of RFRP-3 in regulating HPG axis and its potential applications in the synchronization of reproduction and its therapeutic interventions to prevent stress-induced amenorrhea.

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“…Early reports indicated that RFRP-3 attenuated GnRH-stimulated gonadotropin synthesis and the release from primary cultures of porcine anterior pituitary cells ( Zmijewska et al, 2020 ). Furthermore, GnRH secretion from porcine hypothalamic explants was suppressed upon treatment with RFRP-3 ( Li et al, 2013 ).…”

Section: Neuropeptide Modulators Of Gnrh Neuronal Activity Gnrh Secretion and Reproduction That Act Directly On Gnrh Neuronsmentioning

confidence: 99%

“…Furthermore, GnRH secretion from porcine hypothalamic explants was suppressed upon treatment with RFRP-3 ( Li et al, 2013 ). Additionally, there was a study demonstrated that RFRP-3 inhibits the Kisspeptin-activated GnRH firing rate in vitro, but the addition of RFRP-3 to porcine cultured pituitary cells had no antagonistic effect on the Kisspeptin-induced stimulation of LH secretion ( Wu et al, 2009 ; Zmijewska et al, 2020 ). These results indicate that RFRP-3 may be a negative regulator of pituitary gonadotropin synthesis and release via GnRH neurons.…”

Section: Neuropeptide Modulators Of Gnrh Neuronal Activity Gnrh Secretion and Reproduction That Act Directly On Gnrh Neuronsmentioning

confidence: 99%

The neuroendocrine pathways and mechanisms for the control of the reproduction in female pigs

et al. 2021

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Within the hypothalamic-pituitary-gonad (HPG) axis, the major hierarchical component is gonadotropin-releasing hormone (GnRH) neurons, which directly or indirectly receive regulatory inputs from a wide array of regulatory signals and pathways, involving numerous circulating hormones, neuropeptides, and neurotransmitters, and which operate as a final output for the brain control of reproduction. In recent years, there has been an increasing interest in neuropeptides that have the potential to stimulate or inhibit GnRH in the hypothalamus of pigs. Among them, Kisspeptin is a key component in the precise regulation of GnRH neuron secretion activity. Besides, other neuropeptides, including neurokinin B (NKB), neuromedin B (NMB), neuromedin S (NMS), α-melanocyte-stimulating hormone (α-MSH), Phoenixin (PNX), show potential for having a stimulating effect on GnRH neurons. On the contrary, RFamide-related peptide-3 (RFRP-3), endogenous opioid peptides (EOP), neuropeptide Y (NPY), and Galanin (GAL) may play an inhibitory role in the regulation of porcine reproductive nerves and may directly or indirectly regulate GnRH neurons. By combining data from suitable model species and pigs, we aim to provide a comprehensive summary of our current understanding of the neuropeptides acting on GnRH neurons, with a particular focus on their central regulatory pathways and underlying molecular basis.

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Effect of kisspeptin and RFamide-related peptide-3 on the synthesis and secretion of LH by pituitary cells of pigs during the estrous cycle

Cited by 10 publications

References 45 publications

GnRHand the photoperiodic control of seasonal reproduction: Delegating the task to kisspeptin andRFRP‐3

GnRHand the photoperiodic control of seasonal reproduction: Delegating the task to kisspeptin andRFRP‐3

RFamide peptides, the novel regulators of mammalian HPG axis: A review

The neuroendocrine pathways and mechanisms for the control of the reproduction in female pigs

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