Effect of Ketanserin on the Hyperreactivity of Platelets to 5-Hydroxytryptamine in Patients with Cardiovascular Diseases

Knowledge discovery based on an implicit and explicit conceptual network

“…From Table 2 and Figure 4, the main intermediate concepts are related to “calcium channel,” “vasodilation,” and “platelet aggregation,” and the main intermediate chemical compounds are “serotonin,” “arachidonic acid,” “prostaglandin/epoprostenol,” and “histamine.” The PRIME‐1988 data in the edge link reveals that Mg 2+ is related to serotonin secretion (Baudouin‐Legros, Dard, & Guicheney, 1986) and Mg 2+ controls prostaglandin/ epoprostenol reactivity (Altura, Carella, & Altura, 1980) and regulates histamine metabolism (Nishio, Ishiguro, & Miyao, 1987). By clicking the edge and reading linked abstracts, we can easily find that serotonin, histamine, and prostaglandin/epoprostenol cause vasodilation (Griffith & Burnstock, 1983; Knigge, Alsbjorn, Thuesen, Siemssen, & Christiansen, 1988; Bush, Busst, Booth, Knight, & Shinebourne, 1986) and inhibit platelet aggregation (De Cree, Leempoels, Demoen, Roels, & Verhaegen 1985; Smith, 1981) and that vasoconstriction and platelet aggregation cause migraine (Berde & Fanchamps, 1975; Carrieri, Sorge, Orefice, De Feo, & Fioretti, 1984). The highly scoring abstract in the edge link between “arachidoic acid” and “platelet aggregation,” on the other hand, reveals that arachidonic acid induces platelet aggregation (Tur'ianov, Lomazova, Kazanskaia, Chumakova, & Poliakova, 1983), and PRIME‐1988 data in the edge link indicates that magnesium deficiency increases the amount of arachidoic acid (Thomas‐Benhamou, Rayssiguier, Cardot, Gueux, & Trugnan, 1988).…”