The Role of the Endothelium in the Cardiovascular Response to Serotonin

Vanhoutte, Paul M.; Nueten, J. M. Van; Janssens, W. J.

doi:10.1007/978-94-009-1912-9_12

Serotonin 1990

DOI: 10.1007/978-94-009-1912-9_12

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The Role of the Endothelium in the Cardiovascular Response to Serotonin

Paul M. Vanhoutte

J. M. Van Nueten²,

W. J. Janssens³

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1999

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Cited by 3 publications

(1 citation statement)

References 52 publications

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“…This response is either direct or is provoked by amplification of vasoconstrictive effects of other agents (3). On the other hand, activation of endothelial 5-HT 1 -receptors leads to vasodilation, a nitric oxide (NO)-mediated indirect effect (4). Endothelial NO prevents platelet adhesion and aggregation and, hence, thrombus formation and further 5-HT-release (4).…”

mentioning

confidence: 99%

Beneficial Effect of Serotonin 5-HT2-Receptor Antagonism on Renal Blood Flow Autoregulation in Cyclosporin-Treated Rats

Verbeke

Voorde²,

Ridder³

et al. 1999

Journal of the American Society of Nephrology

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Abstract. Renal blood flow (RBF) autoregulation reappears in postischemic rat kidneys during serotonin (5-HT2) antagonism. The aim of the present study was to analyze whether 5-HT2 antagonism can ameliorate impaired RBF autoregulation in rats treated with 20 mg/kg per d cyclosporin A during 10 d. Autoregulation of RBF was assessed during stepwise lowering of renal perfusion pressure from 110 to 70 mmHg by gradual compression of the aorta. Autoregulation was lost in the cyclosporin A-treated rats. During administration of the 5-HT2 antagonist ritanserin (0.6 mg/kg intravenous bolus, followed by 1.2 mg/kg per h intravenous infusion during 1 h), autoregulation acutely reappeared. Intrarenal bolus injections of a selective 5-HT2-agonist, 2,5 dimethoxy-4-iodoamphetamine hydrochloride, elicited a significantly stronger renal vasocontraction in cyclosporin A-treated rats than in control rats. This finding was also observed with serotonin after nitric oxide-synthase blockade. These results (1) show the importance of 5-HT2-receptor-mediated vasoconstriction in the suppression of vasodilatory autoregulation of RBF in experimental cyclosporin A-induced renal dysfunction and (2) demonstrate that the complete loss of RBF autoregulation is not due to damage of the vascular smooth muscle cells.

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confidence: 99%

Beneficial Effect of Serotonin 5-HT2-Receptor Antagonism on Renal Blood Flow Autoregulation in Cyclosporin-Treated Rats

Verbeke

Voorde²,

Ridder³

et al. 1999

Journal of the American Society of Nephrology

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Serotonin and the regulation of renal blood flow in acute renal failure

Lameire¹

1999

American Journal of Kidney Diseases

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Evaluation of ketanserin in the prevention of restenosis after percutaneous transluminal coronary angioplasty. A multicenter randomized double-blind placebo-controlled trial.

Serruys¹,

Klein²,

Tijssen³

et al. 1993

Circulation

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The Role of the Endothelium in the Cardiovascular Response to Serotonin

Cited by 3 publications

References 52 publications

Beneficial Effect of Serotonin 5-HT2-Receptor Antagonism on Renal Blood Flow Autoregulation in Cyclosporin-Treated Rats

Beneficial Effect of Serotonin 5-HT2-Receptor Antagonism on Renal Blood Flow Autoregulation in Cyclosporin-Treated Rats

Serotonin and the regulation of renal blood flow in acute renal failure

Evaluation of ketanserin in the prevention of restenosis after percutaneous transluminal coronary angioplasty. A multicenter randomized double-blind placebo-controlled trial.

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