Effect of Keggin Heteropoly Acids on Human Embryo Fibroblast Cells

Green Catalysts in the Synthesis of Biopolymers and Biomaterials

“…The increase in acidity in the microenvironment of oncogenic cells favors the stability of anions with a high charge, which guaranteed greater cytotoxicity. [46] Chafran et al used Keggin heteropolyacids, H 3 PW 12 O 40 .nH 2 O, supported on activated carbon (H 3 PW/C) by the evaporation impregnation method as heterogeneous catalysts in polymerization reactions of a racemic mixture of D,L-lactic acid in order to form the polymeric blend poly-D,Llactic acid that has great applicability both in the packaging industry and in the biomedical field as an absorbable, semipermanent, and injectable material that is able to gradually restore volume and stimulate collagen production. [47,48] In the method, until then unpublished in the literature, it was observed that the heterogeneous catalyst presented high enantioselectivity as a function of the L-lactic acid isomer, whose content in the polymeric chain increases as the reaction time varies, with predominance of the L configuration compared to the configuration D-lactic acid in the polymeric blend at approximately 85 % (reaction time 15 h).…”

“…Thus, HPAs containing silicon registered high toxic activity when in contact with the biological target. The increase in acidity in the microenvironment of oncogenic cells favors the stability of anions with a high charge, which guaranteed greater cytotoxicity [46] …”

“…Kovalevskii et al. monitored the effects of commercial heteropoly acids H 3 PW 12 O 40 , H 3 PMo 12 O 40 , H 4 SiW 12 O 40 and H 4 SiMo 12 O 40 on the development of Human Embryo Fibroblast Cells (HEF) in the Eagle culture medium [46] . The study revealed that cytotoxicity increased in the following order: H 3 PMo 12 O 40 <H 3 PW 12 O 40 <H 4 SiW 12 O 40 <H 4 SiMo 12 O 40 , whose greatest cytotoxic action was observed in HPAs that contained silicon as a heteroatom.…”

“…These materials have achieved high importance in the biomedical field, such as in anti-tumor and in antiviral treatments. [44,45] Kovalevskii [46] The study revealed that cytotoxicity increased in the following order: H O 40 , whose greatest cytotoxic action was observed in HPAs that contained silicon as a heteroatom. The monitoring considered the penetration of the anion inside the cell, its transport to a biological target (for example, DNA), and the anion's ability to destroy the biological 8À from pH ∼ 7 were observed.…”