Effect of Isofluorane Anesthesia on Serum Levels of Zn, Cu, Fe, Mn and Co in Humans

Alarcon, O. M.; Reinosa, J; Rangel, Oriol; Silva, T.; Chacón, Azael Eduardo Contreras

doi:10.1016/s0946-672x(96)80030-7

Cited by 3 publications

(4 citation statements)

References 21 publications

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“…20 Noteworthy were the low serum-zinc levels before surgery in the otherwise healthy young patients included in our trial. This was most likely due to the local infection because infections in general can cause hypozincemia [52][53][54] and the serumzinc levels increased significantly in our study following surgical removal of the abscess beyond the time point of serumzinc depression due to the surgical trauma. 55 Metronidazole is often prescribed for malodorous wounds.…”

Section: Discussionmentioning

confidence: 58%

A randomized, double‐blind, placebo‐controlled multicenter trial evaluating topical zinc oxide for acute open wounds following pilonidal disease excision

Ågren

Ostenfeld

Kallehave

et al. 2006

Wound Repair Regeneration

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The purpose of this randomized, double-blind, placebo-controlled multicenter trial was to compare topical zinc oxide with placebo mesh on secondary healing pilonidal wounds. Sixty-four (53 men) consecutive patients, aged 17-60 years, were centrally randomized to either treatment with 3% zinc oxide (n = 33) or placebo (n = 31) by concealed allocation. Patients were followed with strict recording of beneficial and harmful effects including masked assessment of time to complete wound closure. Analysis was carried out on an intention-to-treat basis. Median healing times were 54 days (interquartile range 42-71 days) for the zinc and 62 days (55-82 days) for the placebo group (p = 0.32). Topical zinc oxide increased (p < 0.001) wound fluid zinc levels to 1,540 (1,035-2,265) microM and decreased (p < 0.05) the occurrence of Staphylococcus aureus in wounds. Fewer zinc oxide (n = 3) than placebo-treated patients (n = 12) were prescribed postoperative antibiotics (p = 0.005). Serum-zinc levels increased (p < 0.001) postoperatively in both groups but did not differ significantly between the two groups on day 7. Zinc oxide was not associated with increased pain by the visual analog scale, cellular abnormalities by histopathological examination of wound biopsies, or other harmful effects. Larger clinical trials will be required to show definitive effects of topical zinc oxide on wound healing and infection.

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Section: Discussionmentioning

confidence: 58%

A randomized, double‐blind, placebo‐controlled multicenter trial evaluating topical zinc oxide for acute open wounds following pilonidal disease excision

Ågren

Ostenfeld

Kallehave

et al. 2006

Wound Repair Regeneration

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“…In subsequent literature, the effects of isoflurane on trace elements have been investigated. (15,16) According to the results of the study conducted by Alarcon (17) ; it has been pointed out that the significant increase in serum Zn + occurred in the postoperative period and the authors have concluded that alterations in the serum levels of these elements predominate only after a considerable time, and the variations in serum cation con-centrations very likely result from surgical trauma and not from isoflurane anesthesia. In our study since we could not have evaluated the levels of trace elements for a considerably longer duration, and the effect of surgical trauma could not have been excluded similar to Alarcon's study, it is hard to blame anesthetic agents for these variations in the levels of trace elements.…”

Section: Discussionmentioning

confidence: 99%

“…(24) Since propofol, which was introduced in 1977 eliminated most of the disadvantages of the other intravenous agents and achieved widespread use, we have preferred to perform the anesthesia induction in both groups, and maintenance in TIVA group with this wellknown intravenous agent. (17) Higgins investigated potential effects of propofol on trace elements detected in critically ill patients. However its impact on patients in the operating rooms has not been studied.…”

Section: Discussionmentioning

confidence: 99%

Effect of Different Anesthetic Techniques on Trace Elements: TIVA vs Inhalation Anesthesia

Ceylan¹,

Eroğlu²,

Yavuz³

et al. 2011

J Turk Anaesth Int Care

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Aim: We aimed to compare two different anesthetic techniques (total intravenous anesthesia and inhalation anesthesia) with respect to their effects on trace elements.Material and Method: Patients were randomly allocated into two groups. After standart anesthesia induction; anesthesia was maintained with total intravenous anesthesia with 50 % O 2 /N 2 O mixture and propofol infusion in Group TIVA (n=18) or inhalation anesthesia with 6 % desflurane, and 50 % O 2 /N 2 O mixture in Group INH (n=17). In collected blood samples plasma zinc, copper, and aluminium levels were analyzed preoperatively and at postoperative 1 st , 24 th , and 72 nd hours.Results: In Group TIVA, Zn + levels at postoperative 24. and 72. hours decreased significantly when compared with preoperative levels (p=0.006 and 0.001, respectively), and postoperative 1. hour Cu ++ levels decreased significantly, and 24. and 72. hour Cu ++ levels decreased highly significantly relative to preoperative levels (p=0.006, and p=<0.0001, respectively). In Group INH, postoperative 1. hour Zn + levels decreased significantly, 24. hour levels decreased very significantly and 72. hour Zn + levels decreased significantly according to preoperative values (p=0.004, <0.0001 and 0.001 respectively). Postoperative 72. hour Cu ++ levels decreased significantly compared to preoperative levels (p=0.025).Conclusion: All of the results were in normal clinical ranges, so the anesthetic regimen and trace element correlation needs to be supported by further studies. ÖZET Farklı Anestezi Tekniklerinin Eser Elementler Üzerine Etkisi: TIVA ve Inhalasyon AnestezisiAmaç: İki farklı anestezi tekniğini (total intravenöz anestezi ve inhalasyon anestezisi) eser elementler üzerine olan etkileri açısından kıyaslamayı amaçladık.Gereç ve Yöntem: Hastalar randomize olarak iki gruba ayrıldı. Standart anestezi indüksiyonunu takiben anestezi idamesi Grup TIVA olgularda (n=18) % 50 O 2 /N 2 O karışımı ve propofol infüzyonu olarak total intravenöz anestezi ile; Grup INH olgularda (n=17) % 50 O 2 /N 2 O karışımı ve % 6 desfluran inhalasyonu ile sağlandı. Preoperatif, postoperatif 1., 24. ve 72. saatlarde alınan kan örneklerinde plazma çinko, kurşun ve alüminyum seviyeleri analiz edildi. Bulgular: Grup TIVA da postoperatif 24. ve 72. saatte Zn + seviyeleri preoperatif değerlere göre azaldı (p=0.006, p=0.001). Postoperatif 1. saat Cu ++ seviyeleri anlamlı, 24. ve 72. saat Cu ++ seviyeleri preoperatif değerlere göre çok anlamlı azaldı (p=0.06, p<0.0001). Grup INH da Zn + seviyeleri preoperatif değerlere göre postoperatif 1. saatte anlamlı, 24. saatte çok anlamlı ve 72. saatte anlamlı azaldı (p=0.004, p<0.0001, p=0.001) ve postoperatif 72. saat Cu ++ seviyeleri preoperatif değerlere göre anlamlı azaldı (p=0.025).Sonuç: Tüm sonuçlar normal klinik aralıklar arasında idi; anestezi rejimi ve eser element ilişkisinin ileri çalışmalarla desteklenmeye gereksinimi olduğunu düşünüyoruz.Anahtar kelimeler: Eser elementler, anestezi; inhalasyon, anestezi; intravenöz J Turk Anaesth Int Care 2011; 39(1):1-9

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“…Στον αντίποδα αυτών των µελετών, ερευνητές όπως οι Higgins TL, et al159 (2000), υποστηρίζουν ότι και άλλοι αναισθητικοί παράγοντες εκτός από την προποφόλη, όπως τα οπιούχα αναλγητικά, µειώνουν τη µέση συγκέντρωση του ασβεστίου στο πλάσµα, αυξάνοντας την απέκκριση του στοιχείου αυτού µε τα ούρα, σε Σύµφωνα µε µελέτες των Alarcon OM. et al (1996)174 , το πτητικό αναισθητικό ισοφλουράνιο, δεν επηρεάζει τα επίπεδα ψευδαργύρου και χαλκού στο πλάσµα. O ψευδάργυρος όµως είναι το ιχνοστοιχείο εκείνο που επηρεάζεται µε την υποθερµία κατά τη διεγχειρητική περίοδο, και εµφανίζει µείωση της συγκέντρωσής του στο πλάσµα175 .…”

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Εκτίμηση των μεταβολών των συγκεντρώσεων των στοιχείων Ca Mg Zn Cu κατά την περιεγχειρητική περίοδο σε περιπτώσεις χολοκυστεκτομών

Ντόνας¹

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ΤΣΟΥΚΑΛΗ -ΠΑΠΑ∆ΟΠΟΥΛΟΥ ΕΛΕΝΗ ΚΑΘΗΓΗΤΡΙΑ ΝΤΟΥΓΚΟΥ ΤΖΑΟΥ ΣΑΜΟΥΗΛ ΑΝ. ΚΑΘΗΓΗΤΗΣ ΤΣΟΥΓΚΑΣ ΜΑΤΘΑΙΟΣ ΑΝ. ΚΑΘΗΓΗΤΗΣ ΚΕΛΕΠΟΥΡΗ -ΠΑΡΛΑΠΑΝΗ ΑΓΓΕΛΙΚΗ ΚΑΘΗΓΗΤΡΙΑ ΑΛΒΑΝΟΥ -ΑΥΠΑΡΑΚΗ ΑΘΑΝΑΣΙΑ ΚΑΘΗΓΗΤΡΙΑ ΨΑΡΟΥΛΗΣ ∆ΗΜΗΤΡΙΟΣ ΚΑΘΗΓΗΤΗΣ ΡΑΪΚΟΣ ΝΙΚΟΛΑΟΣ ΕΠΙΚ. ΚΑΘΗΓΗΤΗΣ «Η έγκριση της ∆ιδακτορικής ∆ιατριβής υπό της Ιατρικής Σχολής του Αριστοτελείου Πανεπιστηµίου Θεσσαλονίκης, δεν υποδηλώνει αποδοχή των γνωµών του συγγραφέως».

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Effect of Isofluorane Anesthesia on Serum Levels of Zn, Cu, Fe, Mn and Co in Humans

Cited by 3 publications

References 21 publications

A randomized, double‐blind, placebo‐controlled multicenter trial evaluating topical zinc oxide for acute open wounds following pilonidal disease excision

A randomized, double‐blind, placebo‐controlled multicenter trial evaluating topical zinc oxide for acute open wounds following pilonidal disease excision

Effect of Different Anesthetic Techniques on Trace Elements: TIVA vs Inhalation Anesthesia

Εκτίμηση των μεταβολών των συγκεντρώσεων των στοιχείων Ca Mg Zn Cu κατά την περιεγχειρητική περίοδο σε περιπτώσεις χολοκυστεκτομών

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