Effect of Ischemic Exercise of Varying Muscle Mass and Arterial Occlusion on Maximal Vascular Conductance

Polichnowski, Aaron J.; Heyer, Ellen K.; Wyrick, Shelly L.; Ng, Alexander V.

doi:10.1097/00005768-200305001-00227

Cited by 2 publications

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“…This makes it difficult to determine the extent to which these responses reflect the effects of augmented arterial perfusion pressure and sympathoexcitation vs. the intrinsic vasodilatory capacity of the arterial vasculature (33). By contrast, 10 min of arterial occlusion without contractions do not result in significant elevations in systolic or diastolic pressure, as shown in the present study, and have been shown to yield equally high levels of peak calf conductance compared with ischemic contractions to fatigue, both in younger and older subjects (28,33). Therefore, the use of a 10-min period of arterial occlusion without contractions appears to be a "cleaner" yet equally effective stimulus for producing maximal arteriolar dilation in skeletal muscle and comparing this response between limbs and between younger and older men.…”

Section: Subjectscontrasting

confidence: 49%

Age and regional specificity of peak limb vascular conductance in women

Ridout¹,

Parker²,

Proctor³

2005

Journal of Applied Physiology

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The influence of age on limb vasodilator capacity in women is unclear. The objectives of this study were to characterize and compare age-associated changes in forearm and calf peak vascular conductance (VC(peak); a functional index of arterial structure) in women and to identify physiological characteristics predictive of variation in limb-specific VC(peak). Peak conductance (plethysmographic flow/mean arterial pressure), VC(peak) of the forearm (forearm VC(peak)), and calf (calf VC(peak)) after 10 min of arterial occlusion were measured in 58 healthy, normally active women aged 21-79 yr. Aerobic capacity (cycle peak oxygen uptake), arterial health (pulse-wave velocity, ankle-brachial index), total cholesterol, limb-specific tissue composition (dual-energy X-ray absorptiometry), and isometric strength (handgrip, plantar flexion) were also assessed. The relative decline in calf VC(peak) with age (-6.8% per decade, P < 0.001) was greater than the forearm (-4.4% per decade, P = 0.004), in contrast to results previously reported for men (forearm decline > calf decline). Limb VC(peak) per kilogram muscle declined with age in the calf (-6.0% per decade; P = 0.002), but not the forearm (P = 0.12). Age, cholesterol, and regional tissue composition were significant predictors of peak conductance in both limbs; however, age was a stronger predictor of peak conductance in the calf. These results suggest that healthy aging is associated with a linear decline in limb vasodilator capacity in women, but the magnitude of this effect is region specific. Further research will be required to determine whether the decline in lower extremity vasodilator capacity with age explains diminished exercising leg vasodilation in older women.

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Section: Subjectscontrasting

confidence: 49%

Age and regional specificity of peak limb vascular conductance in women

Ridout¹,

Parker²,

Proctor³

2005

Journal of Applied Physiology

View full text Add to dashboard Cite

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Age and regional specificity of peak limb vascular conductance in men

Proctor

Ridout

2005

Journal of Applied Physiology

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Because of methodological variation in previous studies, age-associated changes in peak limb vascular conductance (VC(peak); a functional index of arterial structure) and its determinants remain poorly defined. The objectives of this study were to describe and compare age-associated changes in peak forearm and calf conductance across a broad age range and to identify physiological characteristics that are predictive of variation in limb-specific VC(peak). Peak conductance (plethysmographic flow/brachial mean arterial pressure) of the forearm (forearm VC(peak)) and calf (calf VC(peak)) after 10 min of arterial occlusion was measured twice in 68 healthy, normally active men aged 20-79 yr. Aerobic capacity (cycle peak oxygen consumption), arterial health (ankle-brachial index, pulse wave velocity), and limb-specific measures of muscle mass (dual-energy X-ray absorptiometry) and isometric strength (grip, plantar flexion) were also assessed. The relative decline in forearm VC(peak) with age (-6.6% per decade; P < 0.001) was greater than the decline in calf VC(peak) (-3.4% per decade; P = 0.004). Limb VC(peak) per kilogram of muscle declined with age in the forearm (-3.8% per decade; P = 0.004) but not in the calf (P = 0.35). Age, Vo(2 peak), and regional muscle mass were significant predictors of peak conductance in both limbs; however, these predictors explained considerably less variance in the calf than in the forearm. These results suggest that healthy aging is associated with a linear decline in limb vasodilator capacity in men, but the magnitude of this effect is reduced in the calf relative to the forearm. This could reflect regional differences in habitual muscle use with aging in normally active men.

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Effect of Ischemic Exercise of Varying Muscle Mass and Arterial Occlusion on Maximal Vascular Conductance

Cited by 2 publications

References 0 publications

Age and regional specificity of peak limb vascular conductance in women

Age and regional specificity of peak limb vascular conductance in women

Age and regional specificity of peak limb vascular conductance in men

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