Effect of intravitreal bevacizumab on iris vessels in neovascular glaucoma patients

Sugimoto, Yoshiaki; Mochizuki, Hideki; Okumichi, Hideaki; Takumida, Masaya; Takamatsu, Michiya; Kawamata, Seiichi; Kiuchi, Yoshiaki

doi:10.1007/s00417-010-1406-x

Cited by 32 publications

(19 citation statements)

References 27 publications

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“…2e), corresponding to some previous reports [23][24][25]. However, vessels did not completely disappear from the iridocorneal angle tissue in our specimens.…”

Section: Discussionsupporting

confidence: 87%

Intravitreal bevacizumab treatment for neovascular glaucoma: histopathological analysis of trabeculectomy specimens

Yoshida

Hisatomi

Ikeda

et al. 2011

Graefes Arch Clin Exp Ophthalmol

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“…2e), corresponding to some previous reports [23][24][25]. However, vessels did not completely disappear from the iridocorneal angle tissue in our specimens.…”

Section: Discussionsupporting

confidence: 87%

Intravitreal bevacizumab treatment for neovascular glaucoma: histopathological analysis of trabeculectomy specimens

Yoshida

Hisatomi

Ikeda

et al. 2011

Graefes Arch Clin Exp Ophthalmol

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“…[58–60] There have even been studies reporting NVG regression after treatment with anti-VEGF agents, with or without PRP. [61–63] …”

Section: Discussionmentioning

confidence: 99%

Neovascular glaucoma after vitrectomy in patients with proliferative diabetic retinopathy

Kwon

Jee²,

La³

2017

Medicine

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To evaluate the prevalence and risk factors of neovascular glaucoma (NVG) after vitrectomy in patients with vitreous hemorrhage associated with proliferative diabetic retinopathy (PDR). This retrospective, noncomparative, observational study included 127 eyes of 127 patients with PDR who received vitrectomy with a follow-up period of at least 6 months. The prevalence of NVG and associated risk factors were assessed including sex, age, previous panretinal photocoagulation, baseline intraocular pressure, combined phacovitrectomy, and pretreatment with intravitreal bevacizumab (IVB) before vitrectomy for the treatment of vitreous hemorrhage. NVG developed in 15 (11.8%) of 127 patients. Of the 15 eyes with NVG, 11 cases (73.3%) postoperatively developed NVG within 6 months. Postoperative NVG was associated with preoperative IVB treatment (odds ratio, 4.43; P = 0.019). The prevalence of NVG after vitrectomy was 11.8%, and an associated risk factor for NVG was preoperative IVB for the treatment of vitreous hemorrhage.

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“…Moreover, it did not decrease the risk of postoperative hyphema. Sugimoto et al [21], using resected irises from NVG patients during trabeculectomy, reported that IVB reduced the neovascularization on the iris surface but could not completely eliminate neovascularization in the iris stroma. They also reported that IVB did not prevent postoperative complications at 1 day after trabeculectomy, including hyphema [21].…”

Section: Discussionmentioning

confidence: 99%

“…Sugimoto et al [21], using resected irises from NVG patients during trabeculectomy, reported that IVB reduced the neovascularization on the iris surface but could not completely eliminate neovascularization in the iris stroma. They also reported that IVB did not prevent postoperative complications at 1 day after trabeculectomy, including hyphema [21]. Takihara et al, performing IVB 1 to 5 days before the trabeculectomy for NVG patients, reported that preoperative IVB did not significantly improve the surgical outcomes, in common with our study [20].…”

Section: Discussionmentioning

confidence: 99%

Hyphema is a risk factor for failure of trabeculectomy in neovascular glaucoma: a retrospective analysis

et al. 2014

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BackgroundSeveral retinal ischemic diseases can cause neovascular glaucoma (NVG). Trabeculectomy with mitomycin C (MMC) is a relatively better treatment modality in the management of eyes with NVG than other glaucoma surgeries. The aim of this study was to investigate the factors that may influence the outcome of trabeculectomy with MMC for NVG.MethodsForty-nine NVG eyes from 43 patients (26 males and 17 females) underwent primary trabeculectomy with MMC. The mean follow-up period was 16.8 ± 8.1 months (range, 6 to 34 months). Twenty-one eyes of 21 patients received intravitreal bevacizumab (IVB) 3.6 ± 1.8 days before trabeculectomy with MMC. A Kaplan-Meier survival-curve analysis was used to summarize the cumulative probability of success. We examined the relationship between the surgical outcome and the following surgical factors: gender, age, history of panretinal photocoagulation, history of cataract surgery, history of vitrectomy, preoperative IVB, NVG in the fellow eye, and postoperative complications (hyphema, choroidal detachment, and formation of fibrin) by multivariate analysis.ResultsThe survival rate was 83.7% after 6 months, 70.9% after 12 months, and 60.8% after 24 months. The Kaplan-Meier survival curves showed no significant difference in the survival rate between the eyes with preoperative IVB (n = 21) and the eyes without preoperative IVB (n = 28) (p = 0.14). The multiple logistic regression analysis showed that postoperative hyphema (odds ratio, 6.54; 95% confidence interval, 1.41 to 35.97) was significantly associated with the surgical outcome (p = 0.02).ConclusionsPostoperative hyphema was significantly correlated with the outcome of trabeculectomy for NVG. There was no significant association between preoperative IVB and postoperative hyphema or the results of trabeculectomy.

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Effect of intravitreal bevacizumab on iris vessels in neovascular glaucoma patients

Cited by 32 publications

References 27 publications

Intravitreal bevacizumab treatment for neovascular glaucoma: histopathological analysis of trabeculectomy specimens

Intravitreal bevacizumab treatment for neovascular glaucoma: histopathological analysis of trabeculectomy specimens

Neovascular glaucoma after vitrectomy in patients with proliferative diabetic retinopathy

Hyphema is a risk factor for failure of trabeculectomy in neovascular glaucoma: a retrospective analysis

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