Effect of Intravenous Methylprednisolone on Pain after Intertrochanteric Femoral Fracture Surgery

Rahimzadeh, Poupak; Imani, Farnad; Faiz, Seyed Hamid Reza; Nikoubakht, Nasim; Sayarifard, Azadeh

doi:10.7860/jcdr/2014/8232.4305

Cited by 7 publications

(4 citation statements)

References 36 publications

(51 reference statements)

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“…Adjuvant analgesics to opioids are being studied to decrease the required dose and the consequent unwarranted effects of opioids. For this purpose, employing adjuvant medication for prolonging motor and sensory block, and proper analgesia is very important ( 10 ). Regional magnesium sulfate and narcotics are known adjuvants used in surgeries.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Intravenous Magnesium Sulfate Versus Intravenous Sufentanil on the Duration of Analgesia and Postoperative Pain in Patients with Tibia Fracture

et al. 2017

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BackgroundIn the recent decades controlling postoperative pain has become a popular topic as it leads to the patients’ wellbeing and improved life quality, while it reduces the costs for both patients and medical facilities.ObjectivesThis study aimed at comparing intravenous magnesium sulfate versus intravenous sufentanil on the duration of analgesia and postoperative pain in patients undergoing tibia fracture surgery.MethodsThis double blind clinical trial study was performed on 70 candidates of tibia fractures between the ages of 18 and 55 years with American society of anesthesiologists (ASA) class I and II. The patients were randomly divided to 2 groups, 1 receiving magnesium sulfate (M) and another receiving sufentanil (S). Both of the groups underwent spinal anesthesia with 10 mg bupivacaine 0.5%. One hour after ensuring the sensorimotor blockade, in the S group 0.1 µg/kg/hour and in the M group 8 mg/kg/hour was diluted in 1 liter of Ringer’s solution and infused. In this study, full weakness of the lower limb was considered as the sign of sensorimotor blockade initiation. The postoperative pain intensity was measured using the Visual Analog Scale (VAS), 0, 1, 4, 8, 16, and 24 hours after the end of anesthesia duration. In case of VAS ≥ 3, the patients received 0.3 mg/kg pethidine, intravenously. At last, the time of requesting the first narcotic drug and the total usage of pethidine were recorded.Results and ConclusionsSufentanil was found to be more effective than magnesium sulfate in reducing postoperative pain and the time of first narcotics request was later in patients receiving sufentanil (P < 0.05).

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Section: Discussionmentioning

confidence: 99%

The Effect of Intravenous Magnesium Sulfate Versus Intravenous Sufentanil on the Duration of Analgesia and Postoperative Pain in Patients with Tibia Fracture

et al. 2017

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“…Inflammation makes a number of cellular courses that result in a higher concentration of opioid receptors at the peripheral nerve terminals. This, as well as other alterations in intra- and extracellular mechanisms, leads to the increased antinociceptive effectiveness of peripherally administered opioids in inflamed tissue ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

“…Recent research on postoperative pain management supports a treatment approach known as “multimodal analgesia,” which comprises the use of more than one method or modality for pain control and management (e.g., drugs from two or more classes) to achieve additive advantageous effects, to reduce side effects, or both ( 18 , 19 ). Multimodal analgesia is actually a well-adjusted analgesia technique for postoperative pain management achieved through a multimodal approach with the synergistic effect of several analgesics and a consequent decrease in the associated side effects as a result of lower individual doses ( 1 , 20 - 22 ). Non-steroidal anti-inflammatory drugs (NSAIDS) combined with opioids provide a favorable option for the effective management of postoperative pain; however, adverse effects and contraindications may limit their use ( 19 , 23 - 25 ).…”

Section: Introductionmentioning

confidence: 99%

Diclofenac Suppository vs. IV Acetaminophen Combined With IV PCA for Postoperative Pain Management in Patients Undergoing Laminectomy: A Randomized, Double-Blinded Clinical Trial

et al. 2016

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BackgroundTissue damage caused by surgical procedures nearly always results in pain. The effective management of postoperative pain remains a challenge because of its influence on the surgical outcome and its critical role in early mobilization and functionality. Recent research on postoperative pain management supports a treatment approach known as “multimodal analgesia,” which comprises the use of more than one method or modality of pain control and management.ObjectivesIn the present study, we compared the effects of diclofenac suppository and intravenous (IV) acetaminophen combined with IV patient-controlled analgesia (PCA) for pain management after laminectomy surgery.Patients and MethodsOur randomized, double-blinded controlled trial during 2013 at Besat hospital in Hamadan, Iran, included 102 ASA I-II patients aged 18 to 65 years who were candidates for laminectomy surgery. The patients were randomly assigned to receive the diclofenac suppository (100 mg) (n = 51) or IV acetaminophen (1 g in 100 mL normal saline) (n = 51) 10 minutes before completing surgery and 12 hours after the operation.ResultsThe patients’ characteristics were the same in both study groups. The patients’ satisfaction levels were higher among those who received diclofenac when compared with the acetaminophen group, especially at the time points of 6 and 12 h after surgery. The consumed narcotic using the PCA pump within 24 h of surgery in the diclofenac group was significantly lower than that of the acetaminophen group (735.70 ± 59.61 µg vs. 819.70 ± 80.02 µg; P < 0.001).ConclusionsThe use of diclofenac suppository combined with IV PCA results in reduced narcotic usage and a higher level of patient satisfaction compared to the use of IV acetaminophen combined with IV PCA.

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“…DCR causes mild to moderate postoperative pain ( 2 ). The postoperative pain control practices pose one of the major challenges in anesthesia and surgery ( 3 , 4 ). Various methods have been proposed for that purpose and acute pain services are provided in hospitals, even though the techniques to curtail postoperative acute pain, ranging from the prescription of painkillers before operation to central and peripheral nerve blocks, each have proven their own especially useful effects ( 5 - 8 ).…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study on the Efficacy of Oral Memantine and Placebo for Acute Postoperative Pain in Patients Undergoing Dacryocystorhinostomy (DCR)

Rahimzadeh¹,

Imani²,

Nikoubakht³

et al. 2017

Anesth Pain Med

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BackgroundMemantine is an N-methyl-D-Aspartate (NMDA) antagonist. By transferring acute postoperative pain, the NMDA channels may lead to active excess and neuropathic pain. Objectives: This study attempted to investigate the effect of preoperative use of single oral dose of memantine in controlling Dacryocystorhinostomy (DCR) postoperative pain.MethodsA double-blind clinical trial was conducted on 60 patients undergoing DCR. On arrival at the operating room, the memantine group received 20 mg of oral memantine and the control group received placebo. The severities of pain by visual analogue scale (VAS) and sedation by Ramsy Scale were measured immediately 1, 2, and 6 hours after the operation. The drug’s side effects were recorded.ResultsThe pain scores of patients in the recovery in 1, 2, and 6 hours after operation were significantly lower in the memantine group than the placebo group (P < 0.001). The sedation score, 1 hour after the operation, was significantly greater in the memantine group than the placebo (P < 0.001). The sedation scores did not have any statistically significant difference in recovery and 2 hours after surgery between the two groups. Moreover, the sedation scores in 6 hours after the surgery were identical in the two groups.ConclusionsThe oral single-dose 20 mg of memantine administered before DCR can reduce postoperative pain compared with placebo.

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Effect of Intravenous Methylprednisolone on Pain after Intertrochanteric Femoral Fracture Surgery

Cited by 7 publications

References 36 publications

The Effect of Intravenous Magnesium Sulfate Versus Intravenous Sufentanil on the Duration of Analgesia and Postoperative Pain in Patients with Tibia Fracture

The Effect of Intravenous Magnesium Sulfate Versus Intravenous Sufentanil on the Duration of Analgesia and Postoperative Pain in Patients with Tibia Fracture

Diclofenac Suppository vs. IV Acetaminophen Combined With IV PCA for Postoperative Pain Management in Patients Undergoing Laminectomy: A Randomized, Double-Blinded Clinical Trial

A Comparative Study on the Efficacy of Oral Memantine and Placebo for Acute Postoperative Pain in Patients Undergoing Dacryocystorhinostomy (DCR)

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