Effect of Intrauterine Infusion with Liquid Paraffin on Phagocytes Migrating to Mucus of External os of the Cervix in Cows

Lu, Wengeng; Zabuli, Jahid; Kuroiwa, Takenobu; Tanaka, Tomomi; Kamomae, Hideo

doi:10.1111/j.1439-0531.2010.01709.x

Cited by 7 publications

(9 citation statements)

References 30 publications

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“…Furthermore, the number of neutrophils increased significantly in CE cows receiving LP compared with those injected with physiological saline 3, 4, 5 and 8 days post‐infusion. Moreover, monocytes augmented significantly 4, 6, and 24h after infusion (Lu et al, ). In our previous study, the number of neutrophils was higher, but not significantly, in CE cows injected with intrauterine paraffin than other treatment groups (cephapirin benzathine, PGF 2α and 50% dextrose solution) two weeks after the treatment (Makki et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…A lower reproductive performance in LP group can be due to the mechanism of LP in the uterus. In the research conducted by Lu et al (), after the intrauterine infusion of liquid paraffin, phagocytes such as macrophages migrated into the uterus and ameliorated the uterine defence mechanisms during infection. Furthermore, the number of neutrophils increased significantly in CE cows receiving LP compared with those injected with physiological saline 3, 4, 5 and 8 days post‐infusion.…”

Section: Discussionmentioning

confidence: 99%

“…Another non-antibiotic treatment is liquid paraffin (LP), which involves intrauterine infusion in cows (Lu, Zabuli, Kuroiwa, Tanaka, & Kamomae, 2011). Migration of peritoneal macrophages was observed following the intraperitoneal injection of LP in mice, rats and rabbits (Hayashi, Shinohara, & Ohura, 1999;Hisatsune et al, 1983;Inoue, Shinohara, & Ohura, 1997;Shacter, Arzadon, & Williams, 1992;Tsuru et al, 1984).…”

Section: Some Researchers Believe That Intrauterine Infusion Of 50% Dmentioning

confidence: 99%

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Effects of hypertonic dextrose and paraffin solution as non‐antibiotic treatments of clinical endometritis on reproductive performance of high producing dairy cows

Ahmadi

Makki

Mirzaei

et al. 2019

Reprod Domestic Animals

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Contents The objective of this study was to compare the reproductive performance of cows affected by clinical endometritis (CE) following treatment with an intrauterine infusion of 50% dextrose solutions (DEX) and liquid paraffin (LP) as alternative therapies with routine treatments including PGF2α injection and intrauterine infusion of oxytetracycline (OTC). Moreover, the reproductive indices of cows treated with endometritis were compared with those of healthy ones. At postpartum reproductive tract examination (28–35 DIM) in one Iranian dairy farm, cows with CE without any selection were assigned to four groups: (a) OTC, a common treatment in Iran, was administered (5 g) to 396 cows, (b) PGF2α (PG) was injected to 496 cows, (c) dextrose solution (DEX): intrauterine infusion of 50% dextrose solution (200 ml) was done in 427 cows, and (d) liquid paraffin (LP) was administered (100 ml) to 423 cows via intrauterine route. We further assigned 2,233 clinically healthy cows to the control group. The incidence of endometritis was 41.6% in this study. Based on the results of reproductive indices including median days to first AI, days open (DO), first service conception rate, conception rate in 2nd and 3rd services, conception rate in all three services, pregnancy rate < 100 days and pregnancy rate < 200 days, except for median days to first AI in other reproductive indexes, reproductive performance was significantly lower in LP group compared with the healthy cows and other treatment groups (p < 0.05). Except for the first service conception rate and proportion of cows pregnant before 100 days in milk (DIM), there existed no significant difference between the DEX group and the control as far as reproductive performance is concerned (p ≥ 0.05). The first service conception rate was recognizably lower in DEX group compared with OTC and PG (p < 0.05). In conclusion, the use of a non‐antibiotic special solution of dextrose 50% is a good alternative to antibiotic agents concerning the treatment of CE in dairy cows.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Some Researchers Believe That Intrauterine Infusion Of 50% Dmentioning

confidence: 99%

See 1 more Smart Citation

Effects of hypertonic dextrose and paraffin solution as non‐antibiotic treatments of clinical endometritis on reproductive performance of high producing dairy cows

Ahmadi

Makki

Mirzaei

et al. 2019

Reprod Domestic Animals

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“…2005). Although studies aimed at evaluating the immediate response to endometrial physical stimulation are not available in the mare, studies in other species suggest that neutrophil migration into the uterine lumen begins 30 to 60 min after endometrial stimulation (Lu et al. 2011).…”

Section: Methodsmentioning

confidence: 99%

Persistent Breeding‐Induced Endometritis after Hysteroscopic Insemination in the Mare

Ferrer

Lyle

Paccamonti

et al. 2011

Reprod Domestic Animals

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Low-dose insemination has been proposed to reduce persistent breeding-induced endometritis (PBIE) in mares with delayed uterine clearance (DUC). Others proposed that hysteroscopic insemination induces an exaggerated inflammatory response and should be avoided in DUC mares. The objectives here were to evaluate presence and severity of PBIE in normal and DUC mares after hysteroscopic insemination with fresh semen, and to determine if hysteroscopy could be used in DUC mares without inducing excessive inflammation. Reproductively normal (n = 4) and DUC (n = 5) mares received four treatments in random order: uterine body insemination (UB, 1 × 10(9) spermatozoa, 20 ml), hysteroscopic insemination (HYST, 5 × 10(6) spermatozoa, 0.5 ml), sham hysteroscopic insemination (SHAM, semen extender, 0.5 ml) and hysteroscopic infusion of seminal plasma (SP, 0.5 ml). Significantly more DUC (50%) mares than normal (14%) mares accumulated intrauterine fluid 24 h post-treatment. The difference in fluid accumulation between DUC (40%) mares and normal (7%) mares was also significant 48 h post-treatment. Fluid scores were not significantly different between treatments in normal mares. However, treatments HYST and SHAM resulted in significantly higher fluid scores 24 h but not 48 h post-treatment in DUC mares. There was no effect of treatment or mare group on the percentage and total number of neutrophils in uterine fluid 48 h post-treatment. Percentage of neutrophils was correlated with duration of hysteroscopy in normal mares, with procedures lasting ≥ 9 min associated with PBIE. There was no effect of mare group, treatment or duration of hysteroscopy on pregnancy rate. Hysteroscopy induces a transient inflammation that is not more severe than that after conventional artificial insemination, suggesting no contraindication to its use in DUC mares.

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“…Mostly, the antibiotics of choice for intrauterine treatment are chlortetracycline [54] and ceftiofur hydrochloride [66] . Furthermore, peroxyacetic acid [67,68] , meta-cresol sulfonic acid (Lotagen®) [69] , ozone [70] , mixtures prepared from healing herbs (AV/RMI/45) [71] and Pelargonium sidoides extract (EPs 7630) [72] , proteolytic enzymes including chemotrypsin, trypsin and papain [73] , liquid paraffin [74] , hyperimmune sera produced against Arcanobacter pyogenes and Escherichia coli [75] , formo-sulphathiazole, the phytotherapeutic EucaComp® [76] and hypertonic dextrose solution (50%) are also used for intrauterine treatment [77] .…”

Section: Treatment Options For Uterine Infectionsmentioning

confidence: 99%

İneklerde Uterus Enfeksiyonları ve Üreme Performansı Üzerine Etkisi

Kaçar¹,

Kaya²

2014

Kafkas Univ Vet Fak Derg

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Uterine infections affect the hypothalamus, hypophysis, ovaries and uterus. These infections inhibit the development of dominant follicles, prevent both the release of the luteinizing hormone (LH) and ovulation, reduce the size of the corpus luteum (CL), and decrease progesterone production. As these infections reduce fertility or cause infertility, they result in major economic losses. The diagnosis of uterine infections by means of various techniques and the detection of the severity of the infection enable the selection of the most appropriate treatment method and the estimation of the success rate that may be achieved with the application of the particular treatment method selected. This review aims to provide researchers and veterinary practitioners with practical information on the prevalence of postpartum uterine infections and currently applied diagnostic and treatment methods. Keywords: Cow, Uterine diseases , Reproductive performance İneklerde Uterus Enfeksiyonları ve Üreme Performansı Üzerine Etkisi ÖzetUterus enfeksiyonları hipotalamus, hipofiz, ovaryum ve uterus üzerine etki eder. Bu enfeksiyonlar; dominant follikül gelişimini baskılar, luteinize edici hormon (LH) salınımını ve ovulasyonu engeller, korpus luteumun (CL) daha küçük ve progesteron üretiminin daha az olmasına neden olur. Fertilitenin düşmesine veya infertiliteye neden olarak ciddi ekonomik kayıplar oluşturur. Uterus enfeksiyonlarının çeşitli yöntemlerle teşhisi ve enfeksiyon şiddetinin belirlenmesi, uygun tedavi yönteminin belirlenmesine ve tedavi yöntemi başarısının tahminine olanak sağlar. Sunulan derleme ile postpartum uterus hastalıklarının yaygınlığı, güncel teşhis ve tedavi yöntemleri hakkında araştırmacılara ve veteriner hekimlere pratik bilgiler sunulmaya çalışıldı.

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Effect of Intrauterine Infusion with Liquid Paraffin on Phagocytes Migrating to Mucus of External os of the Cervix in Cows

Cited by 7 publications

References 30 publications

Effects of hypertonic dextrose and paraffin solution as non‐antibiotic treatments of clinical endometritis on reproductive performance of high producing dairy cows

Effects of hypertonic dextrose and paraffin solution as non‐antibiotic treatments of clinical endometritis on reproductive performance of high producing dairy cows

Persistent Breeding‐Induced Endometritis after Hysteroscopic Insemination in the Mare

İneklerde Uterus Enfeksiyonları ve Üreme Performansı Üzerine Etkisi

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