Effect of Intrauterine Growth Retardation on the Activities of Fetal Intestinal Enzymes in Rats

Lebenthal, Emanuel; Nitzan, M; Lee, P.C.; Chrzanowski, B; Krasner, Joseph

doi:10.1159/000241387

Cited by 28 publications

(17 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In animals IUGR reduces small intestinal weight, length, and the intestinal weightdength ratio [3,15,16]. In this study, total, small, and large intes tinal lengths were decreased.…”

Section: Discussionsupporting

confidence: 48%

“…In animals, IUGR reduces intestinal and pancreatic growth by a reduction in cell num ber [15,16]. Mucosal disaccharidase, alkaline phosphatase, enterokinase levels, and total pancreatic enzymes are also decreased [15,16].…”

Section: Discussionmentioning

confidence: 99%

“…Mucosal disaccharidase, alkaline phosphatase, enterokinase levels, and total pancreatic enzymes are also decreased [15,16]. Such effects may limit nutrient assimila tion and explain postnatal growth retardation sometimes seen in the IUGR human infant.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Intrauterine Growth on Intestinal Length in the Human Fetus

Shanklin¹,

Cooke²

1993

Neonatology

View full text Add to dashboard Cite

Standards for human fetal intestinal length are not well established but have important implications for the care of the preterm and intrauterine growth-retarded (IUGR) infant. Our purpose was to examine the relationship between intrauterine growth and intestinal length in the human fetus. One hundred infants were studied. Birth weight and gestational age ranged from 76 to 4,385 g and from 12 to 42 weeks, respectively. Twenty-one infants were noted to be IUGR. Intestinal length (total, small, large) increased (p < 0.0001) with birth weight, gestational age, and crownheel length but was reduced in IUGR infants. The ratio of body weight to intestinal length increased with gestation but was also reduced in IUGR infants. In conclusion, a reduced functional mass, as suggested by decreased intestinal length or body weight:intestinal length ratio, may contribute to the poor weight sometimes seen in the very-low-birth weight or IUGR infant.

show abstract

“…In animals IUGR reduces small intestinal weight, length, and the intestinal weightdength ratio [3,15,16]. In this study, total, small, and large intes tinal lengths were decreased.…”

Section: Discussionsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Intrauterine Growth on Intestinal Length in the Human Fetus

Shanklin¹,

Cooke²

1993

Neonatology

View full text Add to dashboard Cite

show abstract

“…We found a tendency for TLR4 mRNA (P=.065) expression to be reduced in jejunal epithelial cells of IUGR rats (Table 6). An inhibitory effect of IUGR on intestinal IAP activity has been observed in rat neonates, but to date, no data are available on the effects of IUGR on IAP gene expression [40]. A down-regulation of TLR4 mRNA levels in the liver but not in the intestine or spleen of adult IUGR rats has been reported [41].…”

Section: Discussionmentioning

confidence: 99%

Perinatal undernutrition alters intestinal alkaline phosphatase and its main transcription factors KLF4 and Cdx1 in adult offspring fed a high-fat diet

Lallès¹,

Orozco-Solís

Bolaños-Jiménez

et al. 2012

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

“…IUGR models based on maternal caloric restriction or surgical manipulation have inconsistent fetal outcomes. Therefore, intrauterine therapeutic interventions have been difficult to evaluate (3,8).…”

Section: Delayed Disaccharidase Development In Iugr Mented (7)mentioning

confidence: 99%

Delayed Disaccharidase Development in a Rabbit Model of Intrauterine Growth Retardation

et al. 2001

View full text Add to dashboard Cite

Intrauterine growth retardation (IUGR) affects almost 10% of infants born in the United States. It may be responsible for delayed gastrointestinal function and is an important cause of perinatal morbidity and mortality. The New Zealand White rabbit provides an optimal model for the study of naturally occurring IUGR. At term, birth weight is determined by fetal position within the bicornuate uterus. The small intestinal disaccharidase enzymes are indicators of bowel maturity and function. To examine potential differences in disaccharidase development between normal and IUGR fetuses, this rabbit model was investigated. Jejunum was harvested at multiple stages in rabbit development including the third trimester fetus, neonate, and adult. Lactase, maltase, and sucrase enzyme activity, as well as total protein content, was determined. Results were analyzed by the 2-tailed t test and ANOVA. Lactase activity appeared in the mid-third trimester, peaked in the early neonatal period, then declined to adult levels. Maltase activity appeared in the early third trimester and gradually rose to adult levels. Sucrase remained at trace levels until the mid-neonatal period, reaching adult levels by weaning. Both lactase and maltase activity were depressed in IUGR fetuses compared with their normal littermates. This pattern of disaccharidase depression continued into the neonatal period until catch-up growth occurred at 2 wk when levels equalized. This report describes differential small intestinal disaccharidase development between normal and growthretarded rabbit fetuses in a naturally occurring model of IUGR. The third trimester is a critical period in the maturation of the fetal gut for the postnatal functions of nutrient propulsion and absorption. The terminal stages of digestion are accomplished by the disaccharide hydrolases, disaccharidases, which are located on the enterocyte brush-border membrane. Disaccharidase activity parallels the digestive needs of the animal and is indicative of intestinal function and maturity. Disaccharidase ontogeny has been described in human (1) and animal models, including fetal and neonatal rabbits (2). Developmental delays in fetal disaccharidase activity have been reported in rat models of surgically created intrauterine growth retardation (IUGR) (3) and fetal rabbit gastroschisis (our unpublished observation).The pregnant New Zealand White rabbit has a bicornuate uterus containing multiple fetuses within individual amniotic cavities ( Fig. 1). By convention, the fetus at the ovarian end is numbered 1. At term, the weight ratio of the growth-retarded fetus (position 3) to the ipsilateral normal fetus (position 1) is consistently 0.85, an example of naturally occurring IUGR (4). We hypothesize that IUGR rabbits are not only small but also have immature gastrointestinal development that impairs postnatal bowel function. To test this hypothesis, we studied the development of small intestinal disaccharidase enzymes. These enzymes are indicators of intestinal maturity and function in both norma...

show abstract

Effect of Intrauterine Growth Retardation on the Activities of Fetal Intestinal Enzymes in Rats

Cited by 28 publications

References 4 publications

Effects of Intrauterine Growth on Intestinal Length in the Human Fetus

Effects of Intrauterine Growth on Intestinal Length in the Human Fetus

Perinatal undernutrition alters intestinal alkaline phosphatase and its main transcription factors KLF4 and Cdx1 in adult offspring fed a high-fat diet

Delayed Disaccharidase Development in a Rabbit Model of Intrauterine Growth Retardation

Contact Info

Product

Resources

About