Perinatal undernutrition alters intestinal alkaline phosphatase and its main transcription factors KLF4 and Cdx1 in adult offspring fed a high-fat diet

Lallès, Jean Paul; Orozco-Solís, Ricardo; Bolaños-Jiménez, Francisco; Coppet, Pierre de; Dréan, Gwenola Le; Segain, Jean–Pierre

doi:10.1016/j.jnutbio.2011.10.001

Cited by 26 publications

(42 citation statements)

References 53 publications

(80 reference statements)

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“…Moreover, regarding the role of intestinal enzymes, AP is considered as a brush border-bound representative enzyme that has a broad range of roles, involving regulation of lipid absorption (16). Its activity increased markedly after fat feeding (13,17,20) and decreased after fasting, while refeeding elevated it to the pre-fasting level (26). AP in rodents is present at its highest level in the duodenum, and its activity decreases gradually toward the jejunum and ileum (10).…”

Section: Discussionmentioning

confidence: 99%

Effect of pectin feeding on obesity development and duodenal alkaline phosphatase activity in Sprague-Dawley rats fed with high-fat/high-energy diet

Šefčíková

Racek

2016

Acta Physiol Hung

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Purpose: The objective of this study was to evaluate whether pectin feeding would affect the small intestinal function and whether these changes would lead to obesity prevention in rats fed with high-fat diet. Three groups of weaned male rats (ad lib. fed; rats fed with diet containing 15% w/w of citrus pectin; restrictedly pair-fed rats) were fed with either a standard diet (9.5% fat) or a high-fat diet (30% fat) for 10 days. Results: Our results revealed that pectin feeding led to significant decreases in body weight, energy intake and fat pad weight in rats fed with the standard as well as high-fat diet. Moreover, compared to the restrictedly pair-fed rats, in both groups of rats fed with the diet containing pectin, significant decrease in duodenal alkaline phosphatase (AP) activity was observed in histochemically stained cryostat sections. In contrast, despite their lower energy intake, restrictedly pair-fed rats showed similar fat pad deposition accompanied by unchanged values of AP activity in comparison to the controls. Conclusions: Our findings indicate that daily pectin consumption could be beneficial in suppressing body weight gain and reducing probability of obesity risk in rats fed with a high-fat diet.

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Section: Discussionmentioning

confidence: 99%

Effect of pectin feeding on obesity development and duodenal alkaline phosphatase activity in Sprague-Dawley rats fed with high-fat/high-energy diet

Šefčíková

Racek

2016

Acta Physiol Hung

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“…Be- cause increased GE has been postulated to be a critical determinant for impaired glucose tolerance (23), we reasoned that the faster delivery of substrates into the duodenum observed in UHF female rats was probably responsible for the higher GIP release stimulation and consequently for potentiating insulin secretion after oral glucose load in these rats. Moreover, feeding an HFD to rats has significant effects on various facets of intestinal architecture and function (12,43,44). However, the adult intestine adapts to an HFD differentially depending on early nutritional status.…”

Section: Discussionmentioning

confidence: 99%

“…In this way, it has been shown that undernutrition affects villus height and crypt depth (9) as well as gastric emptying speed (10,11). Increased intestinal absorption of fatty acids and cholesterol has also been described in undernourished individuals refed with a high-fat diet (HFD) (12). To maintain control of glucose homeostasis, continuous communication between gut and pancreas systems is necessary.…”

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confidence: 99%

Predominant Role of GIP in the Development of a Metabolic Syndrome-like Phenotype in Female Wistar Rats Submitted to Forced Catch-up Growth

et al. 2014

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Catch-up growth has been associated with the appearance of metabolic dysfunctions such as obesity and type 2 diabetes in adulthood. Because the entero-insular axis is critical to glucose homeostasis control, we explored the relevance of the incretins glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) in the development of these pathologies. Offspring of rat dams fed ad libitum (control [C]) or 65% food-restricted during pregnancy and suckling time (undernourished [U]) were weaned onto a high-fat (HF) diet (CHF and UHF, respectively) to drive catch-up growth. Both male and female UHF rats showed an obese phenotype characterized by hyperphagy, visceral fat accumulation, and adipocyte hypertrophy. High-fat diet induced deterioration of glucose tolerance in a sex-dependent manner. Female UHF rats experienced much more severe glucose intolerance than males, which was not compensated by insulin hypersecretion, suggesting insulin resistance, as shown by homeostatic model assessment of insulin resistance values. Moreover, female, but not male, UHF rats displayed enhanced GIP but not GLP-1 secretion during oral glucose tolerance test. Administration of the GIP receptor antagonist (Pro3)GIP to UHF female rats over 21 days markedly reduced visceral fat mass and adipocyte hypertrophy without variations in food intake or body weight. These changes were accompanied by improvement of glucose tolerance and insulin sensitivity. In conclusion, the exacerbated production and secretion of GIP after the catch-up growth seems to represent the stimulus for insulin hypersecretion and insulin resistance, ultimately resulting in derangement of glucose homeostasis. Overall, these data evidence the role of GIP as a critical link between catch-up growth and the development of metabolic disturbances. (Endocrinology 155: 3769 -3780, 2014)

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“…Current data also suggest that the rat's intestine adapts to a high-fat diet differentially depending on early nutrition. This is supported by the finding that whereas in adulthood jejunal alkaline phosphatase activity doubled in response to high-fat diet feeding in control rats, this effect was not recorded in perinatally malnourished rats [11]. Recently, it has been revealed that inactivation of the AP gene (Akp3) resulted in faster weight gain and fat accumulation in mice fed a high-fat diet in comparison with wild-type controls, suggesting www.fhc.viamedica.pl that AP may negatively regulate fat absorption [31].…”

Section: Discussionmentioning

confidence: 56%

“…Its activity displays circa dian fluctuations, i.e. it is dependent on actual feeding conditions [6], becomes significantly decreased after food deprivation [7], and also increases markedly after fat--rich diet feeding [8][9][10][11]. Furthermore, some studies have revealed in rat pups subjected to pre-weaning overnutrition via litter size reduction significantly higher AP activity in the small intestine in comparison with rats nursed in normal nests on days 15 and 20, as well as on days 40, 50 and 80 [2,[12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Effect of neonatal β3-adrenoceptor agonist CL 316,243 treatment on body fat accumulation and intestinal alkaline phosphatase activity in rats from reduced nests

Šefčíková¹,

Racek²

2016

Folia Histochem Cytobiol.

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Introduction. The aim of this study was to evaluate the effects of early life administration of b 3 -adrenoceptor agonist (CL 316,243) on somatic and feeding parameters, obesity development as well as small intestinal enzyme activity in 21-and 40-day-old overfed male Sprague-Dawley rats. Material and methods. To induce postnatal overnutrition, litter size was reduced to 4 pups/litter (small litters, SL); while in normally-nourished groups (NL) the litter size was adjusted to 10 pups/litter. From days 5 to 15, half of the suckling pups from NL and SL groups received CL 316,243 subcutaneously. From 21 st to 40 th day, in the post-weaning period, both control (NL, SL) and CL 316,243-treated (NL-CL, SL-CL) rats had free access to standard diet and water. Body composition was determined by magnetic resonance imaging, blood pressure was measured using non-invasive tail-cuff, and intestinal alkaline phosphatase (AP) activity was assessed by histochemistry. Results. At 21 and 40 days of age the SL rats showed higher body mass, displayed higher adiposity and had significantly increased duodenal and jejunal AP activity compared with NL animals. On day 21, NL and SL rats treated with CL 316,243 showed significantly less fat deposition and jejunal AP activity than the non-treated controls. In contrast, treatment-related changes in adiposity and AP activity were not observed in 40-day-old NL-CL, SL-CL rats. Conclusions. These results indicate that early pharmacological intervention with CL did not permanently influence physiological processes involved in body weight/fat regulation, which resulted in the development of early-programmed overweight status in SL rats after weaning.

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Perinatal undernutrition alters intestinal alkaline phosphatase and its main transcription factors KLF4 and Cdx1 in adult offspring fed a high-fat diet

Cited by 26 publications

References 53 publications

Effect of pectin feeding on obesity development and duodenal alkaline phosphatase activity in Sprague-Dawley rats fed with high-fat/high-energy diet

Effect of pectin feeding on obesity development and duodenal alkaline phosphatase activity in Sprague-Dawley rats fed with high-fat/high-energy diet

Predominant Role of GIP in the Development of a Metabolic Syndrome-like Phenotype in Female Wistar Rats Submitted to Forced Catch-up Growth

Effect of neonatal β3-adrenoceptor agonist CL 316,243 treatment on body fat accumulation and intestinal alkaline phosphatase activity in rats from reduced nests

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