Effect of intraruminal propionic acid infusion on metabolism of mesenteric- and portal-drained viscera in growing steers fed a forage diet: I. Volatile fatty acids, glucose, and lactate2

Seal, CJ; Parker, David S.

doi:10.2527/1994.7251325x

Cited by 55 publications

(84 citation statements)

References 27 publications

(32 reference statements)

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“…Both basal blood GTR and blood GTR during the glucose clamp procedure were enhanced by propionate supplementation. Seal and Parker [8] infused propionic acid into the rumen of growing steers at rates of 0.5 and 1.0 mol·day -1 , which were lower doses than in the present experiment when compared on a per BW basis, and reported that glucose irreversible loss rate increased at the higher propionic acid infusion rate (1.0 mol·day -1 ). On the contrary, Majdoub et al [7] reported that in growing lambs fed rye grass, the apparent glucose turnover was not modified by intraruminal infusion of propionate (0.55 and 0.91 mol·day -1 ), despite a numerical increase which was due to one of six animals.…”

Section: Discussioncontrasting

confidence: 51%

“…Seal and Parker [8] found that in growing steers infused with propionate intraruminally, most of the infused propionate was converted to glucose. Van der Walt [2] reported that in sheep fed lucerne hay at 12-h intervals, 15 to 22% of glucose turnover derived from propionic acid even at the prefeeding period.…”

Section: Discussionmentioning

confidence: 99%

“…Propionate supplementation influences the net flux of glucose in lambs [4] and fat deposition and skeletal muscle growth in wethers [5]. However, the effects of supplementation and intraruminal infusion of propionate on blood glucose kinetics are not persistent in ruminants [6][7][8]. Intraruminal and intravascular infusions of propionate increase the release of insulin and glucagon [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Effect of supplemental calcium propionate on insulin action to blood glucose metabolism in adult sheep

Sano

Fujita

2006

Reprod. Nutr. Dev.

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-An experiment combining a hyperinsulinemic euglycemic clamp procedure of four sequential 2-h periods and an isotope dilution method of [U-13 C]glucose determined the effect of supplemental calcium propionate on blood glucose metabolism during insulin and glucose infusions in adult sheep. They were fed lucerne hay cubes and commercial concentrate with and without supplementary calcium propionate (Prop and Cont diets, respectively) in a crossover design for each 21-day period. At the preinfusion period, blood glucose turnover rate (GTR) was greater (P < 0.05) for the Prop diet than for the Cont diet. Blood GTR, endogenous glucose production rate (EGPR) and the ratio of EGPR to blood GTR were greater (P < 0.01, P < 0.05 and P < 0.05, respectively) for the Prop diet than for the Cont diet. Blood GTR and glucose infusion rate (GIR) increased (P < 0.001) and the ratio of EGPR to blood GTR was reduced (P < 0.01) with increased insulin infusion rates. The maximal GIR tended to be (P < 0.10) greater for the Prop diet than for the Cont diet but plasma insulin concentration at half maximal GIR did not differ between diets. It is suggested that in adult sheep, dietary propionate supplementation enhances insulin action on glucose metabolism, however, changes in measures of tissue responsiveness and sensitivity were not significant. calcium propionate / glucose clamp technique / glucose metabolism / insulin / isotope dilution method / sheep

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Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of supplemental calcium propionate on insulin action to blood glucose metabolism in adult sheep

Sano

Fujita

2006

Reprod. Nutr. Dev.

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“…Majdoub et al [6] also reported modifications in lactate metabolism with propionate supplementation and suggested that these modifications were associated to modifications in glucose metabolism. Other authors [7,8] had reported an increase in glucose turnover in growing steers supplemented with propionate. An increased supply of propionate to growing lambs or to lactating cows has not however been systematically associated to a higher net hepatic production of glucose [6,9,10].…”

Section: Introductionmentioning

confidence: 99%

Propionate supplementation did not increase whole body glucose turnover in growing lambs fed rye grass

et al. 2003

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-The objective of the present study was to investigate the effects of propionate supplementation on whole body glucose turnover in growing lambs fed frozen rye-grass at 1.5 × maintenance using [1-13 C]-glucose. Intraruminal infusion of propionate (0.55 and 0.91 mol·d -1 ) increased the ruminal molar proportions of propionate from 25% with the control to 40% with the highest propionate treatment. It did not however modify glucose turnover (26 mmol·d -1 ·kg -1 ), nor the conversion of its carbon into L-lactate (21%) and alanine (21%), nor glucose recycling (9%). All of the results suggest that in the present conditions glucose turnover and metabolism were not influenced by the supply of propionate.glucose turnover / propionate / growing lambs / [1-13 C]-glucose

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“…The effect on feed intake is the opposite of that expected if oxidation of glucose in enterocytes causes a satiety signal. (5) Intraruminal infusions of mixtures of acetate and propionate increase concentrations of these SCFA reaching the duodenum and unlike hepatocytes, enterocytes oxidise both acetate and propionate (91)(92)(93) . Therefore, oxidation of SCFA by enterocytes is an unlikely mechanism explaining differences in their hypophagic effects in ruminants.…”

Section: Weaknesses In the Modelmentioning

confidence: 99%

Control of food intake by metabolism of fuels: a comparison across species

Allen

Bradford

2012

Proc. Nutr. Soc.

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Research with laboratory species suggests that meals can be terminated by peripheral signals carried to brain feeding centres via hepatic vagal afferents, and that these signals are affected by oxidation of fuels. Pre-gastric fermentation in ruminants greatly alters fuels, allowing mechanisms conserved across species to be studied with different types and temporal absorption of fuels. These fuels include SCFA, glucose, lactate, amino acids and long-chain fatty acid (FA) isomers, all of which are absorbed and metabolised by different tissues at different rates. Propionate is produced by rumen microbes, absorbed within the timeframe of meals, and quickly cleared by the liver. Its hypophagic effects are variable, likely due to its fate; propionate is utilised for gluconeogenesis or oxidised and also stimulates oxidation of acetyl-CoA by anapleurosis. In contrast, acetate has little effect on food intake, likely because its uptake by the ruminant liver is negligible. Glucose is hypophagic in non-ruminants but not ruminants and unlike non-ruminant species, uptake of glucose by ruminant liver is negligible, consistent with the differences in hypophagic effects between them. Inhibition of FA oxidation increases food intake, whereas promotion of FA oxidation suppresses food intake. Hypophagic effects of fuel oxidation also vary with changes in metabolic state. The objective of this paper is to compare the type and utilisation of fuels and their effects on feeding across species. We believe that the hepatic oxidation theory allows insight into mechanisms controlling feeding behaviour that can be used to formulate diets to optimise energy balance in multiple species. Comparative metabolism: Food intake: Hepatic oxidationComparative metabolism can provide a valuable tool to improve understanding of physiological control mechanisms by investigating the similarities and differences across species. This paper addresses comparative aspects of the control of feeding behaviour by peripheral signals generated by oxidation of fuels. Research with rodents and other laboratory species indicates that inhibition of fuel oxidation stimulates feeding, whereas stimulation of oxidation inhibits feeding, and that the signal to brain feeding centres is via hepatic vagal afferents (1) . Feeding behaviour of rats has been related to energy charge in the liver and synergistic effects of metabolic inhibitors suggest an integrated mechanism with a common signal related to hepatic energy status from oxidation of various fuels (2) . However, the liver is only sparsely innervated with afferent fibres and the common hepatic vagus also innervates other tissues, including the duodenum (3) . The enterocyte was recently proposed as the primary sensor for fuel oxidation, casting doubt on a signal from the liver (4) . Evaluation of the ruminant model and comparison with non-ruminant models provides important insight into this issue because pre-gastric fermentation in ruminants greatly alters the type and temporal pattern of absorption of fuels. Rumen micr...

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Effect of intraruminal propionic acid infusion on metabolism of mesenteric- and portal-drained viscera in growing steers fed a forage diet: I. Volatile fatty acids, glucose, and lactate2

Cited by 55 publications

References 27 publications

Effect of supplemental calcium propionate on insulin action to blood glucose metabolism in adult sheep

Effect of supplemental calcium propionate on insulin action to blood glucose metabolism in adult sheep

Propionate supplementation did not increase whole body glucose turnover in growing lambs fed rye grass

Control of food intake by metabolism of fuels: a comparison across species

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