Effect of intraoperative intravenous lidocaine on pain and plasma interleukin-6 in patients undergoing hysterectomy

Oliveira, Clair Motos de; Sakata, Rioko Kimiko; Slullitel, Alexandre; Salomão, Reinaldo; Lanchote, Vera Lúcia; Issy, Adriana Machado

doi:10.1016/j.bjane.2013.07.017

Cited by 13 publications

(7 citation statements)

References 33 publications

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“…A similar effect on dynamics of interleukins was also reported for lidocaine. In particular, according to the de Oliveira et al study, administration of lidocaine at the dose of 2 mg/kg/hour was characterized by a significant decrease in post-operative stress response, including a lower level of IL-6 as compared with placebo groups [15].…”

Section: Discussionmentioning

confidence: 99%

Influence of low-opioid anesthesia in cardiac surgery on dynamics of pro-inflammatory interleukin-6

Loskutov¹,

Maruniak²,

Dryzhyna

et al. 2020

kitp

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Introduction With coronary artery bypass grafting, patients are subjected to additional risk caused by both surgical treatment itself and pathophysiological changes in homeostasis, provoked by the action of anesthetics and cardiopulmonary bypass. Material and methods The study involved 60 patients, who had been subjected to coronary artery bypass grafting with cardiopulmonary bypass. All patients were divided into two groups: group I (30 patients) – low-opioid scheme of anesthesia and group II (30 patients) – standard scheme of anesthetic management. Blood interleukin-6 (IL-6) was identified before and after cardiopulmonary bypass using an ELISA test. Results Having compared IL-6 values between study groups after completion of cardiopulmonary bypass, it was established that IL-6 levels were 27.51% ( p = 0.001) lower in patients of group I compared with the results of patients in group II. Patients in the first group had a significantly shorter time of mechanical ventilation compared to group II (2.1 ±0.7 hours vs. 3.9 ±0.9 hours, p = 0.021). Low cardiac output syndrome was significantly less frequently reported in patients of group I (10.0% vs. 33.3%, p = 0.028). In addition, patients in group I had a significantly shorter time of intensive care unit (ICU) stay (2.5 ±0.7 days vs. 3.5 ±1.0 days, p = 0.044). Conclusions Application of multimodal low-opioid anesthesia was associated with significantly lower IL-6 at the end of surgery, shorter mechanical ventilation duration, less frequent low cardiac output syndrome and need for catecholamines, and shorter ICU stays.

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Section: Discussionmentioning

confidence: 99%

Influence of low-opioid anesthesia in cardiac surgery on dynamics of pro-inflammatory interleukin-6

Loskutov¹,

Maruniak²,

Dryzhyna

et al. 2020

kitp

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“…The 2018 update [17] incorporated 23 new trials, taking the total number of studies to 68. Out of these, 22 examined open abdominal surgery and 20 laparoscopic surgery, including (in addition to a new study in the 2015 version [63]), a further seven trials [64–70] measuring pain at 24 h. The authors also noted that a number of studies reported small variances, and added the novel methodological feature of 95% prediction intervals. These provide an index of dispersion (based on the SD) that suggests how widely the mean effects vary across populations; reporting a prediction interval in addition to the summary estimate and CI illustrate what range of true mean effects might be expected in future settings, and is also helpful in the clinical interpretation of heterogeneity.…”

Section: Is Intravenous Lidocaine Effective In the Treatment Of Postoperative Pain?mentioning

confidence: 99%

The use of intravenous lidocaine for postoperative pain and recovery: international consensus statement on efficacy and safety

et al. 2020

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Summary Intravenous lidocaine is used widely for its effect on postoperative pain and recovery but it can be, and has been, fatal when used inappropriately and incorrectly. The risk‐benefit ratio of i.v. lidocaine varies with type of surgery and with patient factors such as comorbidity (including pre‐existing chronic pain). This consensus statement aims to address three questions. First, does i.v. lidocaine effectively reduce postoperative pain and facilitate recovery? Second, is i.v. lidocaine safe? Third, does the fact that i.v. lidocaine is not licensed for this indication affect its use? We suggest that i.v. lidocaine should be regarded as a ‘high‐risk’ medicine. Individual anaesthetists may feel that, in selected patients, i.v. lidocaine may be beneficial as part of a multimodal peri‐operative pain management strategy. This approach should be approved by hospital medication governance systems, and the individual clinical decision should be made with properly informed consent from the patient concerned. If i.v. lidocaine is used, we recommend an initial dose of no more than 1.5 mg.kg‐1, calculated using the patient’s ideal body weight and given as an infusion over 10 min. Thereafter, an infusion of no more than 1.5 mg.kg‐1.h‐1 for no longer than 24 h is recommended, subject to review and re‐assessment. Intravenous lidocaine should not be used at the same time as, or within the period of action of, other local anaesthetic interventions. This includes not starting i.v. lidocaine within 4 h after any nerve block, and not performing any nerve block until 4 h after discontinuing an i.v. lidocaine infusion.

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“…Lidocaine has analgesic, and anti-inflammatory effects that are induced by reduction of cytokines production through inhibition of neutrophil activation, and the analgesia may persist even after plasma concentration reduction. [ 7 ] Lidocaine IV administration produces an analgesic effect in various pain states, such acute postoperative pain, and neuropathic pain. [ 8 ]…”

Section: Introductionmentioning

confidence: 99%

Effect of intravenous lidocaine infusion on long-term postoperative pain after spinal fusion surgery

Ibrahim¹,

Aly²,

Farrag³

2018

Medicine

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Background:Intravenous lidocaine infusion is known to reduce postoperative pain for days or weeks beyond the infusion time, and plasma half-life in several types of surgical procedures.Objectives:To evaluate the effect of intravenous (IV) lidocaine infusion on long term postoperative pain intensity for 3 months in patients undergoing spinal fusion surgery.Study Design:Prospective randomized, double-blinded study.Setting:Assiut University Hospital, Assiut, Egypt.Methods:Forty patients undergoing spinal fusion surgery were randomized into 2 equal groups (n = 20 in each). Patients in the lidocaine group received IV lidocaine at a dosage of 2.0 mg/kg slowly before induction of anesthesia, followed by lidocaine IV infusion at a rate of 3.0 mg/kg/h until the end of surgery. Patients in the control group received an equal volume of normal saline. The following data were assessed: pain by Visual Analog Score (VAS) at 1 hour, 6 hours, 12 hours, 24 hours, 48 hours, at discharge time, and at 1 month, 2 months, and 3 months post-operation, time to first request for additional analgesia, and total morphine consumption in 24 hours.Results:Lidocaine significantly reduced the postoperative pain score (VAS) for up to 3 months (P < .05), and significantly reduced morphine consumption (4.5 mg vs. 19.85 mg) in the 1st 24 hours postoperative. Lidocaine also significantly, prolonged (P < .05) the time to first request for additional analgesia (9.56 ± 2.06 hours vs 1.82 ± 0.91 hours).Conclusion:Intra-operative lidocaine, when given intravenously as a bolus followed by an infusion, significantly decreased long term postoperative back pain intensity in patients undergoing spinal fusion surgery.

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Effect of intraoperative intravenous lidocaine on pain and plasma interleukin-6 in patients undergoing hysterectomy

Cited by 13 publications

References 33 publications

Influence of low-opioid anesthesia in cardiac surgery on dynamics of pro-inflammatory interleukin-6

Influence of low-opioid anesthesia in cardiac surgery on dynamics of pro-inflammatory interleukin-6

The use of intravenous lidocaine for postoperative pain and recovery: international consensus statement on efficacy and safety

Effect of intravenous lidocaine infusion on long-term postoperative pain after spinal fusion surgery

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