Effect of intralesional bleomycin as an alternative therapy for cystic hygroma

Saha, Amar Kumar; Haque, Shaikh Sayidul; Islam, KM Saiful

doi:10.3329/bmjk.v46i1-2.18233

Cited by 8 publications

(10 citation statements)

References 14 publications

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“…In our study we found that of patients who received sclerotherapy, 1 (5%) patients had received two sessions of bleomycin, 4 (20%) had received three sessions and 15 (75%) had received 4 doses of bleomycin. These results were similar to many other studies in which mostly patients received 3 to 4 sessions of bleomycin for complete resolution [13][14].…”

Section: Discussionsupporting

confidence: 91%

Compare the Outcomes of Sclerotherapy with Bleomycin Versus Surgical Resection in Children with Cystic Hygroma

Khan¹,

Zada²,

Shah³

et al. 2021

PJMHS

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Objective: To compare the outcomes of sclerotherapy with bleomycin versus surgical resection in children with cystic hygroma. Study Design: Comparative/Observational Place and Duration: Paediatric department of Khalifa Gul Nawaz Medical Teaching Institute, Bannu for 20 months duration from 1st August 2019 to 31st March 2021. Methods: Total 40 patients of both genders with ages 1 month to 15 years presented with cystic hygroma were included in this study. Patients' detailed demographics were recorded after written consent from parents/guardians. Patients were divided in to two groups’ i.e. Group A consist of 20 patients and received sclerotherapy with intra-lesional bleomycin and Group B consist of 20 patients received surgical excision. Outcomes were analyzed at post-procedure 3 and 6 months post-procedure and compared the findings between both groups. Results: There was no significant difference observed between both groups regarding age, gender and site of lymphangioma p-value >0.05. In Group A 15 (75%) patients showed excellent results, 3 (15%) patients showed good results and 2 (10%) showed poor results. In Group B 13 (65%) showed excellent results, 4 (20%) showed good results and 3 (15%) showed poor results. At final follow-up there were no patient with recurrence in Group A while in Group B 2 (10%) patients had recurrence, Conclusion: It is concluded that sclerosing treatment with bleomycin is a safe and effective treatment modality with no recurrence as compared to surgical rexection. Keywords: Cystic Hygroma, Sclerotherapy, Bleomycin, Surgery, Recurrence

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Section: Discussionsupporting

confidence: 91%

Compare the Outcomes of Sclerotherapy with Bleomycin Versus Surgical Resection in Children with Cystic Hygroma

Khan¹,

Zada²,

Shah³

et al. 2021

PJMHS

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“…The mean age of patients in our study was 3.22 ± 3.39 years, youngest being 11 days and the oldest being 15 years similar to most of the reports. [ 19 20 ] Post sclerotherapy, no major injection-related event or complication occurred. Oral paracetamol was found to be effective for control of pain and fever.…”

Section: Discussionmentioning

confidence: 99%

“…The procedure under sedation is preferred for accurate drug delivery, although we avoided intravenous sedation and managed them on an outpatient basis. [ 19 20 ] Patients were reviewed after 3 weeks for assessment of response and repeat sclerotherapy was given if deemed necessary for a maximum of four sessions.…”

Section: Discussionmentioning

confidence: 99%

Results of injection sclerotherapy with bleomycin in pediatric lymphatic malformations

Kumar

Choudhury

Yadav

et al. 2021

J Indian Assoc Pediatr Surg

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Aim: The aim of the study was to evaluate the results of injection sclerotherapy with bleomycin in pediatric patients with lymphatic malformations. Materials and Methods: In this prospective cohort study, all consenting pediatric patients with macrocystic lymphatic malformations were managed with injection bleomycin sclerotherapy (0.5 mg/kg, not exceeding 5 mg at a time) under ultrasound (US) guidance. After aspirating the cyst fluid bleomycin was instilled intralesionally in a ratio of 5:1 (aspirated cyst fluid volume: diluted bleomycin solution volume). Patients were reassessed at three weekly intervals. The response to therapy was assessed clinically as well as by size and volume on ultrasound Doppler study. The response was classified as excellent response, i.e., complete regression, good response >50% regression, and poor response <50% regression. Results: Sixty patients with lymphatic malformations were enrolled in the study, the mean age was 3.22 years, and the male-to-female was 2.5:1. The most common site of lesion was in the neck (43.3%), followed by the axilla (15%) and flank (8.3%). The responses were excellent, good, and poor in 43 (71.6%), 12 (20%), and five (8.3%) patients, respectively. Two patients underwent surgical excision of the residual lesion. Complications noted were fever in six, local pain in five, and residual lesion in three patients. Conclusion: Sclerotherapy with bleomycin is simple, safe, and effective in the first line of management for macrocystic lymphatic malformations in children.

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“…The etiology of hemangioma remains unknown. Three phases were noted in the evolution of hemangioma namely rapid proliferating phase, involuting phase and involuted phase [3]. The clinical course, severity and complications of the condition depends on the site of occurrence of the lesion like airway obstruction, visual disturbances.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Intra-Lesional Bleomycin Sclerotherapy for the Treatment of Hemangioma-Case Report

Akhil

Gaikwad

Sagar

2021

JPRI

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Vascular anomalies are one of the challenging diseases to manage, presenting in different age groups and with varied clinical course, of which hemangiomas are common which are vasoproliferative neoplasms and can occur in any organ. Depending on the age at presentation they are classified as congenital and infantile hemangiomas. Not much attention has been paid regarding the imaging and treatment modalities of vascular malformations particularly hemangiomas due to scarcity of literature related to this condition. Majority of these vascular malformations are self-limiting, but in a few cases these lesions may grow with age which can be treated surgically or by sclerotherapy which has been the safe, less invasive, economical and easily available modality for treating hemangiomas. Bleomycin is the main sclerosing agent used which is a cytotoxic anti-tumor antibiotic which was later found to have anti-cancer properties. In our case, a 9 year old male child presented to our institution with a lump in the left side of abdomen since birth. Contrast enhanced CT abdomens was suggestive of a vascular malformation. Patient was treated with sclerotherapy with intralesional bleomycin for which good results were noted by decrease in the size and vascularity of the swelling.

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Effect of intralesional bleomycin as an alternative therapy for cystic hygroma

Abstract: Bang Med J Khulna 2013; 46 : 12-15

Cited by 8 publications

References 14 publications

Compare the Outcomes of Sclerotherapy with Bleomycin Versus Surgical Resection in Children with Cystic Hygroma

Compare the Outcomes of Sclerotherapy with Bleomycin Versus Surgical Resection in Children with Cystic Hygroma

Results of injection sclerotherapy with bleomycin in pediatric lymphatic malformations

Efficacy of Intra-Lesional Bleomycin Sclerotherapy for the Treatment of Hemangioma-Case Report

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