Effect of Intestinal Microbiota Transplantation on Intestinal Flora and Inflammatory Factor Levels in Patients with Ulcerative Colitis

Abstract

Objective The present study was performed to evaluate the effect of intestinal microbiota transplantation (IMT) on intestinal flora and inflammatory factor levels in patients with ulcerative colitis (UC). Methods In this study, 94 UC patients who attended the Department of Proctology or the Department of Gastroenterology departments of Sinopharm Dongfeng General Hospital between April 2021 and April 2022 were identified as research participants and were assigned to the control or Research Groups via the random number table method, with 47 cases in each group. Interventions included oral mesalamine for patients in the control group and oral mesalamine plus IMT for those in the research group. Outcome measures included clinical efficacy, intestinal microbiota score, enteroscopy score, Sutherland index, inflammatory factor level, intestinal mucosal barrier function level, and adverse reactions. Results Mesalamine plus IMT was associated with significantly higher treatment efficiency (97.8%) versus mesalamine alone (80.85%) (P<0.05). Mesalamine plus IMT provided a better intestinal microbiota balance and milder disease symptoms versus mesalamine, as evidenced by the significantly lower intestinal microbiota scores, colonoscopy scores, and Sutherland index (P<0.05). In post-treatment, patients with IMT exhibited more mitigated inflammatory responses than those without, as shown by the higher levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-17 (IL-17), and interleukin-23 (IL-23) (P<0.05). Significantly lower D-lactate and serum diamine oxidase (DAO) levels were observed after IMT intervention than those with mesalamine alone (P<0.05). IMT features no significant increase in adverse effects than the control group (P>0.05). Conclusion IMT efficiently ameliorates the intestinal microbiota conditions of UC patients, mitigates inflammatory responses in the body, and facilitates the restoration of intestinal mucosal barrier function with no significant increase in adverse effects.

Effect of Intestinal Microbiota Transplantation on Intestinal Flora and Inflammatory Factor Levels in Patients with Ulcerative Colitis [Letter]

“…I have read the paper by Zhi Wang et al on the Effect of Intestinal Microbiota Transplantation on Intestinal Flora and Inflammatory Factor Levels in Patients with Ulcerative Colitis. 1 I congratulate the authors for providing updated information regarding the role of the gut microbiota in the treatment of patients suffering from Ulcerative Colitis. The findings in this study can be used as a consideration for the choice of therapy for Ulcerative Colitis patients in addition to giving anti-inflammatory drugs such as Dexamethasone because Microbiota Transplantation on Intestinal is still a new therapy in the world of health.…”

“…A study conducted by Zhi Wang et al proved that intestinal microbiota transplantation can improve the condition of the gut microbiota in ulcerative colitis patients, reduce excessive inflammatory responses, and facilitate restoration of intestinal mucosal function without any significant side effects. 1 However, care should be taken in the selection. The right donor is recommended to do an examination of the donor’s bacterial profile first.…”

“…The presence of disturbances in the intestinal microbiota can increase the risk of invasive infection from intestinal pathogens. 1 Therefore, a strategy to restore the composition of the intestinal microbiota is a potential strategy that should be of primary concern to reduce the risk of developing cases of ulcerative colitis. 3 However, I also recommend giving conventional probiotic therapy, which can help maintain remission for a longer time and improve the quality of life of ulcerative colitis patients.…”

“…4 The study conducted by Zhi Wang et al used correspondents of patients diagnosed with ulcerative colitis who were divided into a control group that was given oral mesalamine and an intervention group that was given oral mesalamine plus intestinal microbiota transplantation. 1 The method used has been able to assess the effectiveness of intestinal microbiota transplantation, however I recommend adjunctive therapy such as administration of conventional probiotic strains with common approaches applied in disease management to modify gut microbiota, improve gut barrier integrity and function, and maintain a balanced immune response. 4 In addition, intestinal microbiota transplantation can also help doctors predict the success of ulcerative colitis treatment.…”

Effects of Continuous Nursing on the Disease Uncertainty, Coping Strategies and Quality of Sleep and Life of Patients with Inflammatory Bowel Disease

“…The pathogenesis and aetiology of IBD have been reported to be related to environmental and genetic factors or dysbacteriosis of the intestinal flora. 3 In recent years, the prevalence of IBD has become high globally, and the mortality rate is increasing. 4 However, because the aetiology and pathogenesis of the disease are unclear, and there are differences between individuals, some treatment methods may not completely cure the disease.…”