Effect of Intermittent Food Restriction on Growth, Food Utilization and Body Composition of the Rat

Heggeness, F. W.

doi:10.1093/jn/86.3.265

Cited by 20 publications

(5 citation statements)

References 18 publications

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“…Weight gain was even more severely impaired than was food intake. This is in direct contrast to Heggeness's findings [7], and an explanation is not apparent. It may be that protein catabolism during periods of fasting was sufficient to impair synthesis of key enzymes.…”

Section: Discussioncontrasting

confidence: 89%

“…The finding of increased carcass lipid was similar to that noted by H eggeness [7] and implies an increased amount of adipose tissue per gram of rat and hence a relative obesity even in the presence of decreased body weight.…”

Section: Discussionsupporting

confidence: 85%

“…H eggeness [7,8] has shown that 3 days of ad libitum feeding alternated with 3 days of restricted feeding produces normal weight gain, increased carcass lipid, decreased carcass protein and decreased oxygen consumption. These observations are generally compatible with increased lipogenesis noted in tissues of meal-fed as compared to nibbling rats [1,[9][10][11][12][16][17][18],…”

Section: Introductionmentioning

confidence: 99%

“…The purpose of the study was to compare effects of this more severe dietary aberration to Heggeness's results [7,8] and to correlate changes in body composition with those of tissue metabolism.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Intermittent Feeding on Rat Adipose Tissue and Diaphragm Metabolism

Goldman¹

1972

Ann Nutr Metab

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Effects of intermittent feeding were studied in rats fasted and fed for alternating 3-day periods. After 30 days, rats were sacrified and food intake, weight gain and carcass lipid measured. Fat pads and hemidiaphragms were incubated with U-¹⁴C-glucose or 1–¹⁴C-palmitate. Oxidation and incorporation into tissue lipids were analyzed. Compared to rats fed ad libitum, intermittently fed and fasted animals ate 50% less food, gained 75% less weight and had greater carcass lipid content per gram of weight. Glucose incorporation into lipid was increased in diaphragm and adipose tissue, but oxidation and incorporation into glycogen were increased only in the latter tissue. Palmitate oxidation was unchanged in either tissue, but incorporation into adipose tissue lipid fractions was increased. Conclusions are that intermittent feeding reduces caloric efficiency, stimulates lipogenesis and glucose oxidation, and results in a relative excess of body fat even in the presence of undernutrition.

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Section: Discussioncontrasting

confidence: 89%

Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Intermittent Feeding on Rat Adipose Tissue and Diaphragm Metabolism

Goldman¹

1972

Ann Nutr Metab

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“…Experiments in which growth efficiency of the diet was compared in "trained" rats and those allowed to eat ad libitum have yielded data suggesting that the "trained" rat was more economical in his use of cal ories and had a decreased energy expendi ture (26,27). However, the results were based on a collation of animals differing not only in the periodicity of food con sumption but also in the quantity of food eaten daily.…”

Section: Discussionmentioning

confidence: 99%

Effects of Caloric Intake and Feeding Frequency on Carbohydrate Metabolism of the Rat

Cohn

Joseph

1970

The Journal of Nutrition

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The relationship between quantitative nutrient intake and periodicity of food ingestion on the adaptations of carbohydrate metabolism was studied. Glucose and insulin tolerance tests were conducted on animals that had eaten ad libitum (con trols), were pair-force-fed or force-fed 80% of the nutrient intake of the others. It was found that, compared with the controls, a) the underfed rat was more reactive, the fully-force-fed animal less responsive, to the hypoglycÃ©mieeffects of insulin and b) the undernourished rat disposed of a glucose load at a faster rate, the pair-forcefed rat at a slower or equal rate. The results of glucose tolerance tests performed on relatively undernourished rats "trained" to eat for 2 hours/day or pair-fed animals eating aliquots of their ration hourly were similar. In vitro studies with diaphragms and epididymal fat pads (glucose uptakes and insulin sensitivities) of animals that had eaten ad libitum or were force-fed either 100% or 80% of the nutrient intake of the controls yielded data that do not appear to account fully for the in vivo findings. It is concluded that in studies of metabolic adaptations to altered feeding frequency, one should use pair-fed animals given "optimal" amounts of nutrients, which in this case required force-feeding to equalize intake at the ad libitum level.

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Zur Wirkung einer herabgesetzten Frequenz der Nahrungsaufnahme auf den Fettmetabolismus bei Ratten In vitro‐ und in vivo‐Verwertung von Acetat‐1‐¹⁴C

Bobek

Ginter

Cervén

et al. 1973

Nahrung

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Bei erwachsenen männlichen Ratten wurde der langfristige Einfluß einer herabgesetzten Frequenz der Nahrungszufuhr (2 h täglich) auf die in vitro‐ und in vivo‐Inkorporation von Acetat‐1‐14C in die Gesamtlipide der Leber und in das epididymale Fettgewebe auf den Glykogengehalt der Leber und auf die Körperzusammensetzung beobachtet. Die Adaptation an das 2 h‐Fütterungsregime für die Dauer von 35 Wochen erhöht die Resistenz des Glykogens der Leber gegenüber dem Hunger, ändert aber nicht den Umfang der Leberlipogenese bei den Tieren in nüchternem Zustand. Nur nach der Realimentation kommt es bei den täglich 2 h gefütterten Ratten zur erhöhten Inkorporation von Acetat‐1‐14C in die Gesamtlipide und in das Cholesterin der Leber und zur erhöhten Oxydation zu 14CO2 in diesem Gewebe. Die Verwertung des Acetat‐1‐14C im epididymalen Gewebe wurde durch das 2 h‐Fütterungsregime nicht signifikant beeinflußt, ähnlich wie sich auch der prozentuale Fettgehalt im Körper der Versuchstier nicht geändert hat. Die gewonnenen Ergebnisse werden im Zusammenhang mit dem Alter der verwendeten Tiere diskutiert.

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Effect of Intermittent Food Restriction on Growth, Food Utilization and Body Composition of the Rat

Cited by 20 publications

References 18 publications

Effects of Intermittent Feeding on Rat Adipose Tissue and Diaphragm Metabolism

Effects of Intermittent Feeding on Rat Adipose Tissue and Diaphragm Metabolism

Effects of Caloric Intake and Feeding Frequency on Carbohydrate Metabolism of the Rat

Zur Wirkung einer herabgesetzten Frequenz der Nahrungsaufnahme auf den Fettmetabolismus bei Ratten In vitro‐ und in vivo‐Verwertung von Acetat‐1‐¹⁴C

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Effect of Intermittent Food Restriction on Growth, Food Utilization and Body Composition of the Rat

Cited by 20 publications

References 18 publications

Effects of Intermittent Feeding on Rat Adipose Tissue and Diaphragm Metabolism

Effects of Intermittent Feeding on Rat Adipose Tissue and Diaphragm Metabolism

Effects of Caloric Intake and Feeding Frequency on Carbohydrate Metabolism of the Rat

Zur Wirkung einer herabgesetzten Frequenz der Nahrungsaufnahme auf den Fettmetabolismus bei Ratten In vitro‐ und in vivo‐Verwertung von Acetat‐1‐14C

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Zur Wirkung einer herabgesetzten Frequenz der Nahrungsaufnahme auf den Fettmetabolismus bei Ratten In vitro‐ und in vivo‐Verwertung von Acetat‐1‐¹⁴C