Effect of Intensive Statin Therapy on Coronary High-Intensity Plaques Detected by Noncontrast T1-Weighted Imaging

Noguchi, Teruo; Tanaka, Atsushi; Kawasaki, Terukazu; Goto, Yoichi; Morita, Yoshiaki; Asaumi, Yasuhide; Nakao, Kazuhiro; Fujiwara, Reiko; Nishimura, Kunihiro; Miyamoto, Yoshihiro; Ishihara, Masaharu; Ogawa, Hisao; Koga, Nobuhiko; Narula, Jagat; Yasuda, Satoshi

doi:10.1016/j.jacc.2015.05.056

Cited by 68 publications

(54 citation statements)

References 38 publications

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“…In this context, a study in WHHL rabbits treated with statins over a 1-year period showed a 20% reduction in circulating cholesterol and stabilization of coronary plaques. This was the end product of a decrease in the ratio of foam cells to macrophages and extracellular lipid content as well as an increase in the stabilization components of collagen and smooth muscle cells(13).In the current study(6), the primary endpoint at12 months was a change in the PMR value of HIP, which was accompanied by a decrease in the total and percentage of atheroma volume, total low attenuated plaque (LAP) volume of <30 Hounsfield units, and percentage of LAP volume on CTA compared with a matched control group. On the contrary, propensitymatched controls showed the opposite trends.…”

mentioning

confidence: 49%

Should CMR Become the New Darling of Noninvasive Imaging for the Monitoring of Progression and Regression of Coronary Heart Disease? ∗

Yahagi

Joner

Virmani

2015

Journal of the American College of Cardiology

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mentioning

confidence: 49%

Should CMR Become the New Darling of Noninvasive Imaging for the Monitoring of Progression and Regression of Coronary Heart Disease? ∗

Yahagi

Joner

Virmani

2015

Journal of the American College of Cardiology

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“…Secondly, CTCA allows 3 dimensional volume acquisition rather than accumulating multiple 2 dimensional slices in CMR, which can be time (45). Although plaque characterization by T1W MRI is technically demanding and its use is currently limited to research centers, corroborating data has been published by this group, where they showed that statin therapy reduces the PMR by comparison between propensity-matched cohorts (46).…”

Section: Cardiac Magnetic Resonance Imaging (Cmr)mentioning

confidence: 89%

Prediction of cardiovascular outcomes by imaging coronary atherosclerosis

Pathan

Negishi

2016

Cardiovasc. Diagn. Ther.

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Over the last two decades, several invasive and non-invasive coronary atherosclerosis imaging modalities have emerged as predictors of cardiovascular outcomes in at-risk population. These modalities have demonstrated independent or incremental prognostic information over existing/standard risk stratification schemes, such as the Framingham risk score (FRS), by identifying characteristics of coronary artery diseases (CADs). In this review, we begin with discussing the importance of pre-test probability and quality of outcome measure, followed by specific findings of each modality in relation to prognosis. We focused on both short and long term prognostic aspects of coronary computed tomography (CT) (including coronary calcium score and coronary angiography) and magnetic resonance imaging as non-invasive tools, as well as invasive modalities including intravascular ultrasound (IVUS), optical coherence tomography (OCT), near infrared spectroscopy and Angioscopy.

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“…In another study by the same group, the ability of PMR to monitor therapy with statins was evaluated. In control subjects with CAD who were not treated with statin, PMR significantly increased after 12 months from baseline (from 1.22 to 1.49, a 19.2% increase; p<0.001) but was significantly reduced in patients treated with statin (1.38 to 1.11, an 18.9% reduction; p<0.001) [79]. A contrast-enhanced approach can also be used for plaque characterization with CMR.…”

Section: Coronary Artery Wall Imagingmentioning

confidence: 99%

Cardiac MR Assessment of Coronary Arteries

Hamdy

Ishida

Sakuma

2017

Cardiovasc Imaging Asia

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Imaging of coronary arteries with magnetic resonance has undergone undeniable progress during the past two decades. Although coronary computed tomography angiography detects coronary artery disease (CAD) with excellent diagnostic accuracy, the inevitable exposure to ionizing radiation and iodinated contrast administration make it less appealing in certain patient populations. Coronary magnetic resonance angiography (MRA) is now performed mostly as a whole heart, free breathing, three-dimensional study. Several factors influence quality and speed of the scan, including use of the appropriate pulse sequence according to the strength of the magnetic field, cardiac and respiratory gating, preparation pulses, multi-channel cardiac coils, parallel imaging, and contrast material injection. The use of coronary MRA is well established in coronary artery anomalies and aneurysms. While diagnostic performance has also improved markedly for the detection of CAD, coronary MRA is not yet a routine clinical study. However, coronary MRA is expected to be play a major role in the near future due to continuous research and technical achievements.

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Effect of Intensive Statin Therapy on Coronary High-Intensity Plaques Detected by Noncontrast T1-Weighted Imaging

Cited by 68 publications

References 38 publications

Should CMR Become the New Darling of Noninvasive Imaging for the Monitoring of Progression and Regression of Coronary Heart Disease? ∗

Should CMR Become the New Darling of Noninvasive Imaging for the Monitoring of Progression and Regression of Coronary Heart Disease? ∗

Prediction of cardiovascular outcomes by imaging coronary atherosclerosis

Cardiac MR Assessment of Coronary Arteries

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