Effect of inositol -stabilized arginine silicate on arthritis in a rat model

Şahin, Kazım; Ojalvo, Sara Perez; Akdemir, Fatih; Orhan, Cemal; Tuzcu, Mehmet; Şahin, Nurhan; Özercan, İbrahim Hanifı; Sylla, Sarah; Koca, Süleyman Serdar; Yılmaz, İsmet; Komorowski, James

doi:10.1016/j.fct.2019.01.005

Cited by 4 publications

(3 citation statements)

References 42 publications

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“…Certain nutraceuticals, for example, chondroitin, glucosamine, pentosane polysulfate, avocado/soybean unsaponifiables, milk protein, and green-lipped mussels, are used as add-on therapies [16,44]. Following the purpose of finding the exact remedy against OA, our study group has recently suggested that, in collagen-induced arthritic rats, the arginine-silicate-inositol complex (ASI) is effective in lowering the inflammation markers β-catenin, COX-2, IL-6, MAPK, NF-κB, p38, TNF-α, and WISP-1 levels in the joint tissue of the animals [45].…”

Section: Alternative Non-surgical Treatment Approaches For Oamentioning

confidence: 99%

Undenatured Type II Collagen (UC-II) in Joint Health and Disease: A Review on the Current Knowledge of Companion Animals

Gençoğlu

Orhan

Şahin

et al. 2020

Animals

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OA is quite common in companion animals, especially in large breed dogs and horses. Collagen, the most abundant protein of mammals, has specific connective tissue types for skin, bones, reticulate, basal lamina, bones, cell surfaces, while type II collagen (UC-II) forms the main structure of cartilage tissue. Even at the smaller dosages, UC-II has also been reported to be more effective than the glucosamine and chondroitin sulfate supplements, which are the supplements most frequently used in the market. In this review, we summarize the effects of UC-II on joint health and function in health and disease conditions in companion animals.

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Section: Alternative Non-surgical Treatment Approaches For Oamentioning

confidence: 99%

Undenatured Type II Collagen (UC-II) in Joint Health and Disease: A Review on the Current Knowledge of Companion Animals

Gençoğlu

Orhan

Şahin

et al. 2020

Animals

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“…This effect was particularly strong with the use of MgB in high doses and MgB cream combined with ASI. In previous studies, we demonstrated the anti-inflammatory effects of the ASI complex (Durmus et al, 2017;Sahin et al, 2019). For instance, the ASI complex inhibits the release of proinflammatory and anti-inflammatory cytokines such as IL-6, TNF-α, and IL-1 at the wound site, contributing to effective wound closure (Durmus et al, 2017).…”

Section: Discussionmentioning

confidence: 90%

The Protective Effects of a Combination of an Arginine Silicate Complex and Magnesium Biotinate Against UV-Induced Skin Damage in Rats

et al. 2021

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The purpose of this study was to observe the effects of a novel combination of inositol-stabilized arginine silicate complex (ASI) and magnesium biotinate (MgB) on the prevention of skin damage after UVB exposure in rats. Forty-nine Sprague-Dawley rats were randomized into one of the following groups (Farage et al., 2008): NC, normal control (Gragnani et al., 2014), SC, shaved control (Pandel et al., 2013), UVB (exposed to UVB radiation) (Binic et al., 2013), ASI + MgB-L (Low Dose) (Dunaway et al., 2018), ASI + MgB-H (High Dose) (Dorner et al., 2009), ASI + MgB-L + MgB cream (Durmus et al., 2017), ASI + MgB-H + MgB cream. The results showed that ASI + MgB treatment alleviated the macroscopic and histopathological damages in the skin of rats caused by UVB exposure. Skin elasticity evaluation showed a similar trend. ASI + MgB increased serum Mg, Fe, Zn, Cu, Si, biotin, and arginine concentrations and skin hydroxyproline and biotinidase levels while decreasing skin elastase activity (p < 0.05) and malondialdehyde (MDA) concentration (p < 0.001). Moreover, ASI + MgB treatment increased skin levels of biotin-dependent carboxylases (ACC1, ACC2, PC, PCC, MCC) and decreased mammalian target of rapamycin (mTOR) pathways and matrix metalloproteinase protein levels by the regulation of the activator protein 1 (AP-1), and mitogen activated protein kinases (MAPKs) signaling pathways. In addition, ASI + MgB caused lower levels of inflammatory factors, including TNF-α, NFκB, IL-6, IL-8, and COX-2 in the skin samples (p < 0.05). The levels of Bax and caspase-3 were increased, while anti-apoptotic protein Bcl-2 was decreased by UVB exposure, which was reversed by ASI + MgB treatment. These results show that treatment with ASI and MgB protects against skin damage by improving skin appearance, elasticity, inflammation, apoptosis, and overall health.

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“…Animals receiving no silicon in their diets exhibit growth retardation and poor condition of connective tissue and bones [ 10 ]. Measurements of bone weight and strength in numerous model animals has showed the favorable effect of silicon supplements for increasing bone tissue density and reducing bone fragility [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Experimental Testing of the Action of Vitamin D and Silicon Chelates in Bone Fracture Healing and Bone Turnover in Mice and Rats

et al. 2022

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This study presents findings on the biological action of an integrated supplement containing the following components involved in osteogenesis and mineralization: vitamin D and silicon in the bioavailable and soluble form. A hypothesis that these components potentiate one another’s action and make calcium absorption by the body more efficient was tested. Biological tests of the effect of vitamin D and silicon chelates on bone fracture healing and bone turnover were conducted using ICR mice and albino Wistar rats. Radiographic and biochemical studies show that the supplement simultaneously containing silicon chelates and vitamin D stimulates bone tissue regeneration upon mechanical defects and accelerates differentiation of osteogenic cells, regeneration of spongy and compact bones, and restoration of bone structure due to activation of osteoblast performance. Bone structure restoration was accompanied by less damage to skeletal bones, apparently due to better absorption of calcium from food. The studied supplement has a similar effect when used to manage physiologically induced decalcification, thus holding potential for the treatment of osteomalacia during pregnancy or occupational diseases (e.g., for managing bone decalcification in astronauts).

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Effect of inositol -stabilized arginine silicate on arthritis in a rat model

Cited by 4 publications

References 42 publications

Undenatured Type II Collagen (UC-II) in Joint Health and Disease: A Review on the Current Knowledge of Companion Animals

Undenatured Type II Collagen (UC-II) in Joint Health and Disease: A Review on the Current Knowledge of Companion Animals

The Protective Effects of a Combination of an Arginine Silicate Complex and Magnesium Biotinate Against UV-Induced Skin Damage in Rats

Experimental Testing of the Action of Vitamin D and Silicon Chelates in Bone Fracture Healing and Bone Turnover in Mice and Rats

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