Experimental Testing of the Action of Vitamin D and Silicon Chelates in Bone Fracture Healing and Bone Turnover in Mice and Rats

Abstract

This study presents findings on the biological action of an integrated supplement containing the following components involved in osteogenesis and mineralization: vitamin D and silicon in the bioavailable and soluble form. A hypothesis that these components potentiate one another’s action and make calcium absorption by the body more efficient was tested. Biological tests of the effect of vitamin D and silicon chelates on bone fracture healing and bone turnover were conducted using ICR mice and albino Wistar rats. Radiographic and biochemical studies show that the supplement simultaneously containing silicon chelates and vitamin D stimulates bone tissue regeneration upon mechanical defects and accelerates differentiation of osteogenic cells, regeneration of spongy and compact bones, and restoration of bone structure due to activation of osteoblast performance. Bone structure restoration was accompanied by less damage to skeletal bones, apparently due to better absorption of calcium from food. The studied supplement has a similar effect when used to manage physiologically induced decalcification, thus holding potential for the treatment of osteomalacia during pregnancy or occupational diseases (e.g., for managing bone decalcification in astronauts).

Silicon Supplementation for Bone Health: An Umbrella Review Attempting to Translate from Animals to Humans

“…Rats were the most common animal studied (n = 18 treatments), followed by chicks (n = 13 treatments) and horses (n = 6 treatments), with mice (n = 4 treatments), calves (n = 2 treatments), pigs (n = 2 treatments), and turkeys (n = 1 treatment) making up the rest of the experiments. Two papers [26,36] each included two experiments with two different species. Overall mean ± standard deviations, as well as minimums, maximums, and medians for total standardized Si, Si supplementation amounts, and dietary Si intake, are presented in Table 4.…”

Older adults and vitamin D hip fracture connections-what is the 2022 research base indicating?

“…However, it seems reasonable to suggest that some forms of hip fracture in older populations that are often not treated for possible osteoporotic risk 24 may derive some independent or collective benefit from vitamin D supplementation as far as reducing hip fracture incidence rates as well as mortality rates or further fractures post hip fracture surgery in vulnerable older adults. [24][25][26][27][28] In combination with silicon a recent basic study has revealed some degree of vitamin D influence on bone structure restoration and improved calcium absorption that appears to offer a possible avenue for enhancing bone related regeneration and that may prove valuable to examine further in the realm of hip fracture prevention and that is supported by human clinical evidence, [29][30][31][32] even though its presence may not impact number of falls or injurious falls that often lead to hip fractures. 33 However, there are multiple contrary study findings as well as multiple design problems that remain in this body of research, even though more favorable potentially relevant clinical findings prevail than not.…”