Effect of Injury on Plasma Proteins

Ja, Owen

doi:10.1016/s0065-2423(08)60284-x

Cited by 72 publications

(14 citation statements)

References 188 publications

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“…The total level of protein-bound carbohydrate, and the concentration of one glycoprotein easily measurable (ai-acid glycoprotein), rise in patients with neoplastic disease, and after surgery and other types of trauma (17,18). The present experiments add a previously unrecognized member to the system of normal human plasma glycoproteins: BJC1.…”

Section: Discussionmentioning

confidence: 70%

Isolation of a Novel Glycoprotein from the Urine of a Patient with Chronic Myelocytic Leukemia

Rudman¹,

Chawla²,

Rio³

et al. 1974

J. Clin. Invest.

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A B S T R A C T Patient B. J. witlh chr-oniic myelocytic leukemia excreted 0.5-1.1 g protein per day in the urine. Gel filtration on Sephadex G-75 showed about one-third of this protein to be in molecular weight range 20,000-40,000 (fraction BJC). BJC, prepared from 9 liters of urine by gel filtration, was chromatographed on carboxymethylcellulose. Two BJC2 was found in the urine by immunoelectrophoresis in 10% of patients with neoplastic disease and was not observed in urine of other patients or in human plasma.Amino acid composition, carbohydrate content, and antigenic specificity indicate BJC1 is a previously unrecogniized member of the system of normal human

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Section: Discussionmentioning

confidence: 70%

Isolation of a Novel Glycoprotein from the Urine of a Patient with Chronic Myelocytic Leukemia

Rudman¹,

Chawla²,

Rio³

et al. 1974

J. Clin. Invest.

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“…1.155±-0.065 [30] 1.165±0.039 [24] 1.24440.068 [13] Female 1.148±0.070 [23] 1.177±0.053 [26] 1.254±0.082 [26] More than 20% above ideal weight None 1.187i0.052 [21] 1.253±0.084 [32] Values are in centipoise at 37.0°C, given as mean±SD. The number of subjects in each grouip is shown in brackets.…”

Section: Resultsmentioning

confidence: 99%

“…The four acute phase reactants measured, haptoglobin, a,-acid glycoprotein, a,-antitrypsin, and ceruloplasmin, were elevated more than 25% in diabetic serum. These proteins are called "acute phase reactants" because their levels increase after injury, surgery, and other types of stress or illness (30,31 The observed increase in serum viscosity in diabetes is considerably less than that known to produce symptoms. In the hyperviscosity syndrome, serum viscosity is typically more than doubled (35,37).…”

Section: Discussionmentioning

confidence: 99%

Disturbance of Serum Viscosity in Diabetes Mellitus

McMillan¹

1974

J. Clin. Invest.

112

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A B S T R A C T The serum viscosity of diabetic patients has been found to be increased. The elevation averaged 8% above healthy subjects and 6% above nondiabetic patients. The serum viscosity elevation was greater when diabetic sequelae associated with microangiopathy were present. No relation of serum viscosity to age, sex, obesity, duration of disease, or type of treatment was demonstrated. Serum total protein and glucose levels were found to be correlated with serum viscosity, and increases in their serum concentrations were observed in diabetes. Analysis demonstrated that their elevation did not explain either the viscosity increase or the difference in viscosity between diabetics with and without sequelae.Intrinsic viscosity, abbreviated [n], is a concentrationindependent solute property related to molecular shape.[n] was found to be 7% higher in diabetic than in normal serum. The [X7] difference accounted for at least half of the serum viscosity elevation. The rest of the increase was due to increased serum protein level and increased nonprotein solids, presumably glucose and lipid. Associated with increased [n] was a decline in albumin: globulin ratio and elevation of the acute phase reactant proteins, al-acid glycoprotein, al-antitrypsin, haptoglobin, and ceruloplasmin. Studies comparing diabetic and normal serum fractionated by using 21.5% sodium sulfate showed that changes in [n] were attributable to changes in serum protein composition rather than an inherent qualitative disturbance of protein present in one of the fractions.

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“…This is at variance with the present findings, although in the human studies no account is taken of possible changes in concentration of iron transferrin with the stage of the disease. Iron transferrin is reported to be decreased in iron deficiency anaemia and certain infections, whilst it is increased in haemolytic anaemia and haemorrhage (Owen, 1967). A decrease in iron transferrin, with a concomitant increase in ceruloplasmin, has been demonstrated in e.s.r.…”

Section: Spleenmentioning

confidence: 99%

“…has been used to demonstrate similar increases in the blood of patients with Hodgkin's disease and with cancers of the breast (Foster et al, 1973) and to study the effects of radiotherapy on plasma ceruloplasmin concentrations in a variety of cancer patients (Swartz and Wiesner, 1972). However, serum ceruloplasmin concentrations also increase during pregnancy, acute and chronic infections, collagen disorders and myocardial infarction, following surgery and after administration of oestrogens and thyroid and pituitary hormones (Hrgovcic et al, 1973c;Hughes, 1972;Owen, 1967). Changes in the concentrations of individual plasma proteins are therefore not specific to leukaemia or even to malignant diseases, although some relationship appears to exist between the concentrations of ceruloplasmin and iron transferrin in blood.…”

Section: Spleenmentioning

confidence: 99%

Electron spin resonance study of changes during the development of a mouse myeloid leukaemia. I. Paramagnetic metal ions

Dodd¹

1975

Br J Cancer

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Summary.-The blood, spleen and liver of mice were examined by means of electron spin resonance (e.s.r.), throughout the course of myeloid leukaemia induced by intravenous injection of leukaemic spleen cells. In blood, marked increases in the concentrations of iron transferrin and ceruloplasmin occurred within the first 3 days after injection. In the spleen, changes in the concentrations of paramagnetic copper and iron complexes were detectable by about the 5th day, before any measurable splenic enlargement, whilst in the liver changes were detectable by about the 8th day. The changes occurring in blood, spleen and liver during the development of leukaemia appear to be related and they are discussed in terms of iron transport.

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Effect of Injury on Plasma Proteins

Cited by 72 publications

References 188 publications

Isolation of a Novel Glycoprotein from the Urine of a Patient with Chronic Myelocytic Leukemia

Isolation of a Novel Glycoprotein from the Urine of a Patient with Chronic Myelocytic Leukemia

Disturbance of Serum Viscosity in Diabetes Mellitus

Electron spin resonance study of changes during the development of a mouse myeloid leukaemia. I. Paramagnetic metal ions

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