Effect of Injections of Œstrogen on the Mast Cells of the White Mouse

Arvy, L

doi:10.1038/175506a0

Cited by 17 publications

(6 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A fall in the number of observable mast cells in the uterus and evidence of mast-cell degranulation have been associated with secretion or administration of estrogen (review: Spaziani, 1975). However, administration of estrogen alone (Arvy, 1955) or simultaneous administration of estrogen and progesterone (Maraspin and Bo, 1971) has been associated with increased mast-cell numbers in the uterus. Mast cells are known to be involved in hypersensitivity reactions and in the process of inflammation (review: Bloom, 1974), but the function of mast cells in the general physiology of mammalian organisms has remained obscure despite extensive research (review: Padawer, 1979).…”

mentioning

confidence: 99%

Changes in uterine mast cells during the estrous cycle in the Syrian hamster

Brandon

Evans

1983

Am. J. Anat.

View full text Add to dashboard Cite

Adult virgin female Syrian hamsters were killed at known stages of the estrous cycle, and mast cells were counted in the myometrium, endometrium, and mesometrial-triangle region of the uterus and in the pinna. Tissues were fixed in Helly's solution, and mast cells were stained using 0.06% toluidine blue in 0.12 M Michaelis' veronal acetate-hydrochloric acid buffer, pH 4.5. The number of mast cells in the myometrium and endometrium was found to vary with the estrous cycle, whereas the number in the mesometrial-triangle region and the pinna showed no such variation. The number of mast cells in the myometrium and endometrium was lowest on day 4 of the cycle (the day before the night during which ovulation would occur) and increased approximately twofold to maximal levels found on days 1 and 2. Intermediate levels were seen on day 3. The origin of the increase in mast cell numbers from day 4 to day 1 was investigated using a combined alcian blue--safranin stain to differentiate between immature and mature mast-cell granules. The results obtained did not support the hypothesis that the increase was due to de novo differentiation of mast cells from precursors, but, equally, no evidence was obtained to refute this hypothesis.

show abstract

mentioning

confidence: 99%

Changes in uterine mast cells during the estrous cycle in the Syrian hamster

Brandon

Evans

1983

Am. J. Anat.

View full text Add to dashboard Cite

show abstract

“…Injection of estrogen in mice results in an increased number of mast cells [25], and the effect was most pronounced in females. The synergistic action of estradiol and myelin basic protein on mast cell secretion [26] supports the importance of sex hormones in the demyelinating process.…”

Section: Discussionmentioning

confidence: 99%

Mast cells and multiple sclerosis in females and males

Krüger¹,

Mörk²

2012

WJNS

View full text Add to dashboard Cite

Mast cells were observed in autopsies from 11 females and 8 males. We confirm earlier observations that mast cells are more frequent in close vicinity to MSplaques. In these plaque-border zone areas, defined as the area within 1 mm distance of the actual plaques, the average number of mast cells was 2.34/mm 2 in males and 4.77/mm 2 in females, which in average is appr. 10 times more than earlier observed in MS. The difference in number of mast cells between females and males is significant (p < 0.005) and is of interest since females are more inclined to developing MS than males. Mast cells were rare in areas without visible plaques. The mast cells were preferably located close to capillaries and venules. A mechanism for the probable role of mast cells, based on diet-factors and mast cell mediators in the pathogenesis of MS is discussed.

show abstract

“…Uterine mast cells are known to be influenced by the ovarian hormones, progesterone and estrogen, in the rat (Gibbons and Chang, 1972), and by estrogen in the mouse (Westin, 1955) and guinea pig (Iversen, 1962). Treatment with estrogen has been reported to affect mast cells in subcutaneous tissue in the mouse (Arvy, 1955). The influence of ovarian hor-mones on mast cells in the vole remains to be investigated.…”

Section: Discussionmentioning

confidence: 99%

Observations on uterine mast cells during early pregnancy in the vole, Microtus agrestis

Brandon

Evans

1984

Anat. Rec.

View full text Add to dashboard Cite

The vole, Microtus agrestis, was chosen for this study of mast cells during early pregnancy because this species does not show spontaneous estrous cycles. Mast cell numbers in the uterus are known to vary during the estrous cycle in some species (rat, cow, Syrian hamster). Mast cell changes during early pregnancy in the vole could not reflect hormonal changes which had occurred during a preceding estrous cycle. Mast cells in the uterus (myometrium, endometrium, and mesometrial triangle) and ear skin were examined at 0 hours (virgin, estrus) and at 24, 48, 72 and 96 hours postcoitum (p.c.). The stain used was 0.06% toluidine blue in 0.12 M Michaelis's veronal acetate-hydrochloric acid buffer at pH 4.5. The number of mast cells observed in the uterus was not significantly affected when the nondehydrating fixative used routinely ( Helly 's solution) was substituted by a dehydrating fixative (Carnoy's solution without chloroform). The number of mast cells in the myometrium decreased from 0 to 72 hours p.c. and increased from 72 to 96 hours p.c. There was no significant variation in mast cell numbers in the endometrium. The number of mast cells in ear skin and in the mesometrial triangle decreased from 0 to 48 hours p.c. An increase occurred from 48 to 96 hours p.c. in ear skin and from 72 to 96 hours p.c. in the mesometrium.

show abstract

Effect of Injections of Œstrogen on the Mast Cells of the White Mouse

Cited by 17 publications

References 1 publication

Changes in uterine mast cells during the estrous cycle in the Syrian hamster

Changes in uterine mast cells during the estrous cycle in the Syrian hamster

Mast cells and multiple sclerosis in females and males

Observations on uterine mast cells during early pregnancy in the vole, Microtus agrestis

Contact Info

Product

Resources

About