Effect of Initial Periodontal Therapy on the Frequency of Detecting <i>Bacteroides forsythus, Porphyromonas gingivalis</i>, and <i>Actinobacillus actinomycetemcomitans</i>

Takamatsu, Nobuhiro; Yano, Kazuko; He, Tao; Umeda, Makoto; Ishikawa, Isao

doi:10.1902/jop.1999.70.6.574

Cited by 98 publications

(26 citation statements)

References 47 publications

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“…This study showed significant reductions in the quantity of P. gingivalis and T. forsythia in both groups following nonsurgical periodontal therapy while the level of A. actinomycetemcomitans was unaffected, which is in agreement with previous studies [31–33]. Takamatsu et al [33] investigated the short-term effects of nonsurgical periodontal therapy on the quantity of P. gingivalis and T. forsythia in 26 periodontally diseased patients using DNA probe.…”

Section: Discussionsupporting

confidence: 90%

“…Takamatsu et al [33] investigated the short-term effects of nonsurgical periodontal therapy on the quantity of P. gingivalis and T. forsythia in 26 periodontally diseased patients using DNA probe. The prevalence of A. actinomycetemcomitans was also identified, but, by using PCR, this study demonstrated significant reduction in the levels of P. gingivalis and T. forsythia while levels of A. actinomycetemcomitans were unaffected.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Nonsurgical Periodontal Therapy on Clinical Response, Microbiological Profile, and Glycemic Control in Malaysian Subjects with Type 1 Diabetes

Buzinin

Alabsi

Tan

et al. 2014

The Scientific World Journal

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The association between diabetes mellitus and chronic periodontal disease has long been established. Most of the researches linking these two very common chronic diseases were based on type 2 diabetes mellitus and chronic periodontal disease. However, this study was conducted to investigate the association between type 1 diabetes and chronic periodontal disease in Malaysian subjects. Forty-one Malaysian subjects, of which 20 subjects were type 1 diabetics and with chronic periodontal disease (test group) and 21 subjects with only chronic periodontal disease (control group), were included in the study. Periodontal parameters and plaque samples for microbiological evaluation were done at baseline, 2 and 3 months after nonsurgical periodontal therapy. Blood samples were taken from only the test group and evaluated for HbA1c at baseline and 3 months after periodontal therapy. There were no statistically significant difference in periodontal parameters between groups (P>0.05) and no significant improvement in the level of HbA1c in the test group. Microbiological studies indicated that there were significant reductions in the levels of the tested pathogens in both groups. The results of our study were similar to the findings of several other studies that had been done previously.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Effects of Nonsurgical Periodontal Therapy on Clinical Response, Microbiological Profile, and Glycemic Control in Malaysian Subjects with Type 1 Diabetes

Buzinin

Alabsi

Tan

et al. 2014

The Scientific World Journal

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“…However, this therapy can often be challenged due to the complex and unfavorable radicular morphology, especially in sites of deep periodontal pockets 19 . In these cases, several studies have shown the presence of remnants of Tannarella forsythensis and mainly Aggregactibacter actinomycetemcomitans in periodontal pockets after non-surgical periodontal therapy 28 .…”

Section: Discussionmentioning

confidence: 99%

Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats

et al. 2010

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ObjectiveThe aim of this study was to compare subgingival irrigation with tetracycline hydrochloride (TTC-HCL) as adjunctive treatment to scaling and root planning (SRP) on induced periodontitis in rats. Material and methodsIn 60 rats, periodontal disease was ligature-induced at the mandibular left first molar. After 7 days, the ligature was removed and all animals were submitted to SRP, and divided into 2 groups according to the following treatment: C (n=30) - subgingival irrigation with 1 mL of saline; T (n=30) - subgingival irrigation with 1 mL of TTC-HCL (50 mg/mL). Ten animals in each group were euthanized at 7, 15 and 30 days posttreatment. The histometric values were statistically analyzed (p<0.05). ResultsIn the histometric analysis, at 7, 15 and 30 days, Group T (0.72±0.05 mm2, 0.57±0.14 mm2, 0.62±0.07 mm2), showed less bone loss (p<0.05) than Group C (1.35±0.25 mm2; 1.40±0.31 mm2; 1.29±0.27 mm2), respectively. ConclusionsSubgingival irrigation with TTC-HCL was an effective adjunctive treatment for periodontal disease induced in rats.

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“…Only methods that included intense scaling and prophylaxis followed by application of topical antiseptics allowed for sufficient microbial reduction to permit colonization of the newly implanted A. actinomycetemcomitans strains. These difficulties were not totally unexpected since the clinical literature is replete with indications regarding the difficulty clinicians have in removal and elimination of A. actinomycetemcomitans from the oral cavity of those infected with A. actinomycetemcomitans [1,36–38]. Nevertheless, the intensity of the recolonization of native A. actinomycetemcomitans was surprising in light of the massive inoculation procedure we used to implant the “foreign” A. actinomycetemcomitans .…”

Section: Discussionmentioning

confidence: 99%

Colonization and Persistence of Labeled and “Foreign” Strains of Aggregatibacter actinomycetemcomitans Inoculated into the Mouths of Rhesus Monkeys

Karched

Furgang³

et al. 2015

J Oral Biol

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Aggregatibacter actinomycetemcomitans (Aa) is a pathobiont and part of a consortium of bacteria that can lead to periodontitis in humans. Our aim was to develop a model for oral inoculation of labeled Aa into a suitable host in order to study Aa traits and ecological factors that either enhance or repress its persistence. Primate species were screened for Aa to select a host for colonization studies. Macaca mulatta (Rhesus/Rh) was selected. Rh Aa strains were isolated, subjected to sequencing and functional analysis for comparison to human strains. “Best” methods for microbial decontamination prior to inoculation were assessed. Three groups were studied; Group 1 (N=5) was inoculated with Aa Spectinomycin resistant (SpecR) Rh strain 4.35, Group 2 (N=5) inoculated with Aa SpecR human strain IDH 781, and Group 3 (N=5) the un-inoculated control. Repeated feeding with pancakes spiked with SpecRAa followed high dose oral inoculation. Cheek, tongue, and plaque samples collected at baseline 1, 2, 3, and 4 weeks after inoculation were plated on agar; 1) selective for Aa, 2) enriched for total counts, and 3) containing 50 µg/ml of Spec. Aa was identified by colonial morphology and DNA analysis. Rh and human Aa had > 93–98 % genome identity. Rh Aa attached to tissues better than IDH 781 in vitro (p < 0.05). SpecR IDH 781 was not recovered from any tissue at any time; whereas, RhSpecR 4.35 was detected in plaque, but never tongue or cheek, in all monkeys at all times (> 1 × 105 colonies/ml; p < 0.001). In conclusion, the primate model provides a useful platform for studying integration of Aa strains into a reduced but established oral habitat. Primate derived SpecRAa was consistently detected in plaque at all collection periods; however, human derived Aa was never detected. The model demonstrated both microbial as well as tissue specificity.

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Effect of Initial Periodontal Therapy on the Frequency of Detecting Bacteroides forsythus, Porphyromonas gingivalis, and Actinobacillus actinomycetemcomitans

Cited by 98 publications

References 47 publications

Effects of Nonsurgical Periodontal Therapy on Clinical Response, Microbiological Profile, and Glycemic Control in Malaysian Subjects with Type 1 Diabetes

Effects of Nonsurgical Periodontal Therapy on Clinical Response, Microbiological Profile, and Glycemic Control in Malaysian Subjects with Type 1 Diabetes

Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats

Colonization and Persistence of Labeled and “Foreign” Strains of Aggregatibacter actinomycetemcomitans Inoculated into the Mouths of Rhesus Monkeys

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