Effect of inhaled formaldehyde on learning and memory of mice

Lu, Zhisong; Li, Chang Ming; Qiao, Yan; Yan, Yu; Yang, Xu

doi:10.1111/j.1600-0668.2008.00524.x

Cited by 96 publications

(91 citation statements)

References 26 publications

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“…Experiments on animals have demonstrated that low-level exposure to FA by inhalation has an impact on oxidant stress in a tissue-specific manner [2]. In addition, inhalation of FA has been shown to inhibit learning and memory performance in mice [3].…”

Section: Introductionmentioning

confidence: 99%

Changes in subjective symptoms and allergy state among medical students exposed to low-level formaldehyde 6 months after completion of a gross anatomy dissection course

Mori

Hoshiko

Hara

et al. 2013

Environ Health Prev Med

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Objectives Our purpose was to clarify whether subjective symptoms of low-level formaldehyde (FA) exposure in medical students were transient or persistent and to investigate whether the allergy state changed as a result of exposure. Methods We surveyed the prevalence of medical students' subjective symptoms and their allergy state before, during, and 6 months after completion of a gross anatomy dissection course by using two self-administrative questionnaires. Students completed the first survey at the end of the anatomy course to assess symptoms before and during the course. The second survey was completed 6 months after course completion.Results The prevalence of most subjective symptoms was lower 6 months after the course than during the course. The major symptoms experienced during the course were eye fatigue, runny nose, and dry eyes. The most common symptom 6 months after the course was eye fatigue. Four students continued to experience symptoms even after course completion. Three students developed symptoms only after course completion. Forty-eight students had allergies before the course began and the severity of the allergies did not change after the course. Additionally, the prevalence of most subjective symptoms 6 months after the course was lower than before the course. The patterns of subjective symptoms in the three periods differed between male and female students; the prevalence of most subjective symptoms tended to be higher in females. Conclusions Subjective symptoms resulting from FA exposure during a gross anatomy course were transient and did not affect students' allergy states.

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Section: Introductionmentioning

confidence: 99%

Changes in subjective symptoms and allergy state among medical students exposed to low-level formaldehyde 6 months after completion of a gross anatomy dissection course

Mori

Hoshiko

Hara

et al. 2013

Environ Health Prev Med

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show abstract

“…[13] Inhaled FA has also been shown to cause behavioral and memory disorders in rats and has been defined as probably cytotoxic. [14][15][16] Long-term exposure to FA from 14 to 30 years may cause irreversible neurotoxicity and was suggested to be related to astrocytoma in the brain. [17] Because neurons have an elevated metabolic rate and high content of oxidizable substrates, neural tissues are highly sensitive to free radical attacks.…”

mentioning

confidence: 99%

Nigella sativa protects against formaldehyde-induced neurotoxicity in the rat frontal cortex

Mohamad¹,

Essa²,

Ata³

2015

Anatomy

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Formaldehyde (FA) is a compound commonly used in industry and medicine that can react with different macromolecules such as proteins, nucleic acids and low molecular weight substances as amino acids. [1,2] In particular, anatomists and medical students are exposed to FA gas during cadaver dissections. [3,4] Humans are exposed to FA from direct environmental sources like paint, plywood, cosmetics, cigarette smoke, photochemical smog and even various fruits as well as from the metabolism of xenobiotics. [5,6] FA is accepted as toxic over certain doses and its at high room temperatures its harmful effects increase due to volatility. [7][8][9][10] Physiological FA forms by the metabolism of L-methionine, histamine or methylamine in the body, and contribute to biological methylation by folic acid. [11] Acute exposure to FA causes central nervous system symptoms such as headache, malaise, insomnia, anorexia

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“…Many studies have discussed the toxic effects of FA on the central nervous system [62] [64] [65]. Long-term exposure to FA can lead to irreversible neuro-…”

Section: Experimental Studymentioning

confidence: 99%

Clinical and Experimental Study of the Toxic Neuropsychiatric Effects of Formaldehyde Exposure: Has Garlic a Protective Role?

Soliman¹,

Shalaby²,

Al-sayed³

et al. 2018

ODEM

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Background: The central nervous system is one of the most important systems affected by formaldehyde (FA). Aim of Work: This study was designed to assess its toxic neuropsychiatric effects both clinically and experimentally and the protective effects of garlic. Methods: Clinically: 20 workers in the gross anatomy laboratory and 20 libertarians underwent a standardized clinical assessment including medical, neurological and psychiatric examination. Experimental: 40 male rats were divided randomly into four groups. Group I is control group. Group II received 10 mg/kg of FA intraperitoneally once daily for 14 days. Group III was treated with fresh garlic juice (1 ml/100g body weight) once daily by oral gavage for 14 days. Groups VI received fresh garlic juice plus formaldehyde daily for 14 days. At the end of the experiment, the rats' brains were obtained for histological examination and biochemical analysis. Results: Clinical and psychiatric profile of FA exposed persons' revealed cognitive impaired, anxious and depressed persons. There were hostile persons with more hostility toward outside. Experimentally, hippocampal and frontal superoxide dismutase and reduced glutathione showed highly significant decrease while malondialdehyde and nitric oxide level showed highly significant increase in formaldehyde treated group when compared with control group. Also histopathological changes in the hippocampal and frontal cortices by light microscope revealed many distorted cells with deeply stained shrunked nuclei and cytoplasm was surrounded by vacuolated pale areas in FA exposed group. Minimization of biochemical and histopathological changes were observed in combined formaldehyde and garlic treated group. Conclusion: The profiles of personality arouse dangerous affairs about the toxic impact of FA on persons, family, and society. Formaldehyde-induced neuronal damage, oxidative stress and lipid peroxidation in brain were minimized by addition of garlic.

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Effect of inhaled formaldehyde on learning and memory of mice

Cited by 96 publications

References 26 publications

Changes in subjective symptoms and allergy state among medical students exposed to low-level formaldehyde 6 months after completion of a gross anatomy dissection course

Changes in subjective symptoms and allergy state among medical students exposed to low-level formaldehyde 6 months after completion of a gross anatomy dissection course

Nigella sativa protects against formaldehyde-induced neurotoxicity in the rat frontal cortex

Clinical and Experimental Study of the Toxic Neuropsychiatric Effects of Formaldehyde Exposure: Has Garlic a Protective Role?

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