Effect Of Inhalation Exposure To Kerosene And Petrol-Fumes On Some Anaemia-Diagnostic Indices In Rats

Uboh, F. E.; Ebong, P. E.; Eka, O.U.; Eyong, E. U.; Akpanabiatu, M. I.

doi:10.4314/gjes.v4i1.2442

Cited by 19 publications

(23 citation statements)

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“…The results of this study support our earlier report on the hematotoxicity, growth depression and weight loss associated with exposure of male and female rats to gasoline vapors (Uboh et al, 2005(Uboh et al, , 2008. Also, the hematotoxic effect reported in this study to be associated with exposure of rats to gasoline vapors correlates with the result of the work reported for rats and humans occupationally exposed to benzene and xylene (d 0 Azevedo et al, 1996;Rothman et al, 1996).…”

Section: Discussionsupporting

confidence: 90%

Vitamins A and E reverse gasoline vapors-induced hematotoxicity and weight loss in female rats

et al. 2010

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In this study, gasoline vapors-induced hematotoxicity, growth-depression and weight-loss reversal effect of vitamins A (retinol) and E (α-tocopherol) was assessed in female Wistar albino rats. The rats were exposed to gasoline vapors (17.8 ± 2.6 cm(3)/h/m(3)/day), 6 hours/day, 6 days/week, for 20 weeks. Vitamins A and E at prophylactic dosage (400 and 200 IU/kg/day, respectively) were orally administered to the rats, separately, in the last 2 weeks of exposure. The levels of hemoglobin (Hb), hematocrit or packed cell volume (PCV), red blood cells (RBC), growth rate and weight gain in the rats exposed to the vapors were significantly lower (p < 0.05) compared, respectively, to the levels obtained for control rats. On the other hand, the levels of white blood cells (WBCs) in the test rats were significantly higher (p < 0.05) compared, respectively, with the level obtained for female control rats. These observations indicated that exposure to gasoline vapors may cause hematotoxicity, growth depression and weight loss in female rats. However, administration of vitamins A and E was observed to produce a significant recovery (p < 0.05) in hematotoxicity, growth depression and weight loss observed to be associated with exposure to gasoline vapors, although the rats administered with vitamin E were noted to respond more favorably than those administered with vitamin A. This suggests that although retinol and α-tocopherol may be used to reverse or prevent hematotoxicity, growth depression and weight loss in subjects exposed to gasoline vapors, the reversal potency of α-tocopherol is higher than that of retinol.

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Section: Discussionsupporting

confidence: 90%

Vitamins A and E reverse gasoline vapors-induced hematotoxicity and weight loss in female rats

et al. 2010

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“…The present study revealed that the values of TC, TGs, LDL-C, VLDL-C were increased while the value of HDL-C was decreased in serum of gasoline 80 inhaled male rats compared with control. These results are also obtained in rats exposed to gasoline fumes where there was an increase in mean of plasma TC and LDL-C levels [25], in rats exposed to gasoline vapors where exposure increased TC, TGs, LDL-C, VLDL-C and decreased HDL-C [19], in rats exposed to petrol and kerosene fumes increased TGS and TC [26], and in rabbit fed petroleum contaminated diet revealed alternation in blood lipid concentration [27]. Similar results were observed in orchiectomized rats showing modulated plasma lipid profile [28] and patients on regular hemodialysis [29].…”

Section: Discussionsupporting

confidence: 56%

“…Liver is one of the organs affected by gasoline vapors toxicity [26]. The results of this study indicate that exposure of rats to gasoline vapor caused significant alterations in the biochemical parameters of liver function.…”

Section: Discussionmentioning

confidence: 64%

Protective Effect of Vitamins C and E against Gasoline Vapors Induced Haematological and Biochemical Changes in Male Rats

Sedky¹

2015

J. Sci. Res.

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The present work was designed to investigate the changes in some hematological, biochemical parameters and lipid profile as well as possible protective role of vitamins C and E against gasoline vapors induced toxicity in male rats. The present results showed that gasoline 80 vapors significantly decreased (p≤0.05) the concentration of total serum protein (TSP) and albumin concentrations and increased (p≤0.05) in serum activities of serum aminotransferases (ALT and AST) and alkaline phosphatase (ALP) compared to the control group. Also, exposure to gasoline 80 vapors induced significant decrease (p≤0.05) in hemoglobin concentration, red blood cell count (RBCs), packed cell volume (PCV) and high density lipoprotein cholesterol (HDL-C) compared to control group. On the other hand, exposure to gasoline 80 vapors resulted in significant increase (p≤0.05) in the levels of total cholesterol (TC), triglycerides (TGs), LDLcholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) relative to untreated experimental animals. However, concomitant treatment with gasoline vapors and administration of vitamins C and E exhibited a protective role on the observed toxic effect of gasoline vapors in male rats. The results of the present study indicated that toxic effects of gasoline vapors could be reduced by dietary supplementation of vitamins C and E.

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“…This is similar to report of chronic study by Dede et al [10] using Bonny light crude oil, kerosene and gasoline which showed reduction in haemoglobin (Hb) and PCV levels in albino rats suggesting that long term exposure to petroleum samples could induce anemia. Wachukwu et al [3], Dede et al [4], Ayalogu et al [11] and Uboh et al [12,13] also reported similar observations using gasoline. The reduction in haemoglobin level can be due to suppressive effect of petroleum sample on erythropoiesis [14] or as a result of haemolysis, which was caused by excessive destruction of erythrocytes.…”

Section: Discussionmentioning

confidence: 65%

Effect of Vitamin E on Haematological Parameters in Albino Rats Treated with Gasoline

George

Adegoke

2012

J. Sci. Res.

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This study was carried out to ascertain the antioxidant properties of vitamin E on haematoxicity caused by gasoline in albino rats using the haemoglobin and white cell count as indices. Thirty-five rats fed diet containing 1000iu of vitamin E per 100mg of feed for 2 weeks (to saturation) prior experiment were injected gasoline intraperitoneally while symptoms of toxicity and haematological parameters were monitored. The result showed that feeding on vitamin E diet increased the haemoglobin concentration while decreasing the elevated white cell count observed in gasoline treated rats, thereby conferring some protection against gasoline on the rats. The study also showed dose dependent reduction in haemoglobin concentration and increase white cell count in gasoline treated rats compared with increase haemoglobin and decrease white cell count in vitamin E treated rats. There was significant increase in haemoglobin concentration and decrease white cell count of vitamin E treated rats when compared with gasoline treated rats. This suggests that vitamin E conferred some protection on the rats against the haematotoxic effect of gasoline. Therefore feeding on diet containing vitamin E could help reverse the effect of gasoline intoxication in the body since it acts mainly as an antioxidant.

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Effect Of Inhalation Exposure To Kerosene And Petrol-Fumes On Some Anaemia-Diagnostic Indices In Rats

Cited by 19 publications

References 0 publications

Vitamins A and E reverse gasoline vapors-induced hematotoxicity and weight loss in female rats

Vitamins A and E reverse gasoline vapors-induced hematotoxicity and weight loss in female rats

Protective Effect of Vitamins C and E against Gasoline Vapors Induced Haematological and Biochemical Changes in Male Rats

Effect of Vitamin E on Haematological Parameters in Albino Rats Treated with Gasoline

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