Effect of individualized weight‐loss programmes on adiponectin, leptin and resistin levels in obese adolescent boys

Elloumi, Mohamed; Ounis, Omar Ben; Makni, Emna; Praagh, Emmanuel Van; Tabka, Zouhaïr; Lac, G.

doi:10.1111/j.1651-2227.2009.01365.x

Cited by 73 publications

(98 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The PE program was unable to increase TA values in any of the groups, contrarily to other studies (22). TA and adiponectin multimers seem to require marked reductions in adiposity to improve.…”

Section: Longitudinal Studycontrasting

confidence: 39%

“…Contrarily, another study found no impact on TA levels after a nutritional counseling program in prepubertal Portuguese children, despite the improvement in BMI z-score (BMIzsc) and blood lipids (21). Different results were found in a study involving obese adolescent boys, as improvements in adiponectin levels were obtained both by energy restriction and by exercise separately, moreover, cumulative effects were present when both approaches were combined (22).…”

mentioning

confidence: 88%

See 1 more Smart Citation

Adiponectin and markers of metabolic syndrome in obese children and adolescents: impact of 8-mo regular physical exercise program

et al. 2014

View full text Add to dashboard Cite

Background: Adiponectin circulates as low-, medium-, and high-molecular-weight multimers (LMW, MMW, and HMW) and influences lipid profile and insulin resistance (IR), HMW being considered as the most biologically active form. We aimed to study the relation between adiponectin and markers of metabolic syndrome (MS) in pediatric obesity, and the impact of physical exercise. Methods:The study consisted of a cross-sectional part and an 8-mo physical exercise program. Lipid profile, insulin, glucose, C-reactive protein (CRP), total adiponectin (TA), and homeostasis model assessment IR (HOMA-IR) were measured. Adiponectin multimers were studied in a prepubertal group. results: Obesity is associated with increased dyslipidemia, IR, and inflammation. TA is correlated inversely with adiposity, triglycerides, HOMA-IR, and CRP, and positively with highdensity lipoprotein cholesterol (HDLc)/total cholesterol (TC) ratio. HMW mimicked TA associations. The intervention program led to a reduction of TC, low-density lipoprotein cholesterol (LDLc), insulin, HOMA-IR, and trunk percentage of fat, and an increase of HDLc/TC ratio, in the obese group. BMI improvements prevented adiponectin reduction and correlated with increments in HMW and MMW. conclusion: Obesity-related increase in MS features might be linked to lower adiponectin. HMW and MMW were the multimers that most explained the MS features. The intervention program improved the lipid profile and IR, and prevented the reduction of adiponectin. a diponectin is mainly secreted by adipocytes in humans (1,2), but total adiponectin (TA) levels are paradoxically lower in obese children, and even lower in obese individuals with metabolic syndrome (MS) (3,4).Adiponectin improves lipid metabolism by lowering the synthesis of free fatty acid and stimulating β-oxidation (5).Furthermore, it is inversely related with triglyceride (TG) levels and positively related with high-density lipoprotein cholesterol (HDLc) concentration. A study from our group showed that adiponectin modulates the effect of apo E genotype on lipid profile (6). Adiponectin also presents an anti-inflammatory action, e.g., it inhibits proinflammatory tumor necrosis factor-α (TNF-α) secretion by macrophages. This activity might have an important role in insulin resistance (IR), as TNF-α inhibits insulin signaling (7,8), while adiponectin increases insulin sensitivity (9).In pediatric ages, adiponectin levels correlate negatively with age (6). The difference between genders is well established, with women presenting with higher adiponectin concentrations (6,10). Sexual hormones might underlie sex-related changes as before puberty; no differences are found between genders (11).The body fat distribution influences adiponectin levels, with abdominal obesity associated with lower concentrations (4,12). The association between central adiposity and reduced adiponectin was seen with visceral fat accumulation in children (13) and adults (14).Adiponectin circulates as three complexes: trimers, hexamers (two trimers), and larger...

show abstract

Section: Longitudinal Studycontrasting

confidence: 39%

mentioning

confidence: 88%

Adiponectin and markers of metabolic syndrome in obese children and adolescents: impact of 8-mo regular physical exercise program

et al. 2014

View full text Add to dashboard Cite

show abstract

“…We focused our attention on adiponectin, and we found that the highest circulating levels of this adipocytokine were found in the underweight groups of teens. This observation is consistent with the previously described effects of weight-loss on increases in serum adiponectin (Elloumi et al, 2009). Interestingly, high levels of serum adiponectin have been reported in anorectic patients (Nedvidkova et al, 2005;Pannacciulli et al, 2003).…”

Section: Discussionsupporting

confidence: 82%

Adolescent Obesity Predicts Cardiovascular Risk

Derejczyk¹,

Kłapcińska²,

Sadowska-Krępa³

et al. 2012

Recent Advances in Cardiovascular Risk Factors

View full text Add to dashboard Cite

“…On the basis of the crossover concept, 11 several studies have individualized and calibrated the intensity of exercise training at LIPOXmax and showed that this type of training is efficient for contracting the metabolic dysfunction-related obesity, consequently leading to better lipid oxidation during exercise, as well as body composition and insulin sensitivity improvement in obese children. 6,10,12 The assessment of functional capacity and exercise tolerance is commonly examined in obese subjects by cardiopulmonary exercise test with measurement of respiratory gas exchange, which requires sophisticated equipment and specially trained personnel. Although the cardiopulmonary exercise test remains the gold-standard method of assessing the individual's metabolic, cardio-respiratory fitness and maximal capacity for exercise, the high-intensity nature of exhaustive stress tests may be inappropriate for certain low-fit or patient groups.…”

Section: Introductionmentioning

confidence: 99%

Six-minute walking test predicts maximal fat oxidation in obese children

et al. 2012

Self Cite

View full text Add to dashboard Cite

BACKGROUND: Obesity is associated with reduced exercise maximal fat oxidation rate (FATmax), which is generally assessed by cardiopulmonary cycling test. The six-minute walking test (6MWT) presents an alternative method in patients. OBJECTIVE: The aim of this study was to establish a practical reference equation facilitating the prediction of FATmax from the 6MWT in obese children of both genders. DESIGN: This study is a cross-sectional study using mixed linear and multiple regression models. RESEARCH METHODS AND PROCEDURES: Anthropometric measurements were recorded and submaximal cycling test and 6MWT conducted for 131 school-aged obese children, 68 boys and 63 girls. A multiple regression analysis for FATmax, including six-minute walking distance (6MWD), anthropometric and cardiac parameters as the dependent variables, was performed for the two genders separately. RESULTS: Mean 6MWD and FATmax were 564.9 ± 53.7 m and 126.5 ± 12.1 mg min À1 for boys and 506.7 ± 55.0 m and 120.7 ± 10.0 mg min À1 for girls, respectively. The 6MWD, body mass index, Z-score, fat-free mass, waist and hip circumferences (WC and HC), rest heart rate, and systolic and diastolic blood pressures were highly correlated with FATmax for both genders. There was a significant correlation between 6MWD and FATmax in both boys and girls (r ¼ 0.88 and r ¼ 0.81, Po0.001, respectively). Stepwise regression analyses revealed that the combinations of 6MWD with HC for boys and 6MWD with WC for girls improved the predictability of the model (R 2 ¼ 0.81 for boys and R 2 ¼ 0.72 for girls; Po0.001). CONCLUSION: In obese children, the 6MWT can be used to predict FATmax when formal test of exercise capacity and gas exchange analysis are unavailable or impractical. It is therefore possible to prescript targeted exercises at FATmax, without performing indirect calorimetry, just from a field test.

show abstract

Effect of individualized weight‐loss programmes on adiponectin, leptin and resistin levels in obese adolescent boys

Cited by 73 publications

References 28 publications

Adiponectin and markers of metabolic syndrome in obese children and adolescents: impact of 8-mo regular physical exercise program

Adiponectin and markers of metabolic syndrome in obese children and adolescents: impact of 8-mo regular physical exercise program

Adolescent Obesity Predicts Cardiovascular Risk

Six-minute walking test predicts maximal fat oxidation in obese children

Contact Info

Product

Resources

About