Effect of increased systemic venous pressure on lymph pressure and flow

Szabó, György; Magyar, Zsuzsanna

doi:10.1152/ajplegacy.1967.212.6.1469

Cited by 64 publications

(39 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As shown in Table 1, there generally seems to exist a threshold level in the outflow venous pressure above which thoracic duct flow decreases significantly. In the experiments inserting a catheter in the thoracic duct or in the efferent duct of the caudal mediastinal lymph node, such a threshold has also been observed when raising the outflow level of the catheter (Cole, Witte, Kash, Rodger, Bleisch & Muelheims, 1967;Szab o & Magyar, 1967;Drake et al 1985). In experiments using the interposed cannula in the thoracic duct (W egria et al 1963), a threshold was, however, not observed in anaesthetized dogs.…”

Section: Effect Of Outflow Venous Pressurementioning

confidence: 97%

Lymph Flow Pattern in the Intact Thoracic Duct in Sheep

Onizuka

Flatebø

Nicolaysen

1997

The Journal of Physiology

View full text Add to dashboard Cite

To study the lymph flow dynamics in the intact thoracic duct, we applied an ultrasound transit‐time flow probe in seven anaesthetized and four unanaesthetized adult sheep (.60 kg). In unanaesthetized non‐fasting animals we found that lymph flow in the thoracic duct was always regular pulsatile (pulsation frequency, 5.2 ± 0.8 min−1) with no relation to heart or respiratory activity. At baseline the peak level of the thoracic duct pulse flow was 11.6–20.7 ml min−1 with a nadir of 0–3.6 ml min−1. Mean lymph flow was 5.4 ± 3.1 ml min−1. The flow pattern of lymph in the thoracic duct was essentially the same in the anaesthetized animals. In both the anaesthetized and unanaesthetized animals, the lymph flow response to a stepwise increase in the outflow venous pressure showed interindividual variation. Some were sensitive to any increase in outflow venous pressure, but others were resistant in that lymph flow did not decrease until outflow venous pressure was increased to higher levels. This resistance was also observed in the high lymph flow condition produced by fluid infusion in the anaesthetized animal and mechanical constriction of the caudal vena cava in the unanaesthetized animals. Pulsation frequency of the thoracic duct flow initially increased and then decreased with a stepwise increase in the outflow venous pressure. This initial increase might be a compensatory response to maintain lymph flow against elevated outflow venous pressure. To test the effect of long‐term outflow venous pressure elevation in unanaesthetized sheep, outflow venous pressure was increased by inflation of a cuff around the cranial vena cava for 1, 5 or 25 h. The cuff was inflated to a level where lymph flow was reduced. Lymph flow remained low or decreased further during the entire cuff‐inflation period. We calculated the lymph debt caused by the outflow venous pressure elevation and the amount ‘repaid’ when venous pressure returned to normal. Lymph debt for 25 h was 6400 ml but only 200 ml was repaid. Since we observed no visible oedema formation in the lower body of the sheep, the non‐colloidal components of the lymph must have been reabsorbed into the bloodstream, most likely in the lymph nodes.

show abstract

Section: Effect Of Outflow Venous Pressurementioning

confidence: 97%

Lymph Flow Pattern in the Intact Thoracic Duct in Sheep

Onizuka

Flatebø

Nicolaysen

1997

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…(20) is that the lymph flow is sensitive to the central venous pressure (P RA ). Although there are a number of observations that suggest that lymph flow is sensitive to thoracic duct pressure [28,118-121] and systemic venous pressure [122,123], these results are indirect and not conclusive.…”

Section: Discussionmentioning

confidence: 99%

Quantitative modeling of the physiology of ascites in portal hypertension

Levitt

2012

BMC Gastroenterol

View full text Add to dashboard Cite

Although the factors involved in cirrhotic ascites have been studied for a century, a number of observations are not understood, including the action of diuretics in the treatment of ascites and the ability of the plasma-ascitic albumin gradient to diagnose portal hypertension. This communication presents an explanation of ascites based solely on pathophysiological alterations within the peritoneal cavity. A quantitative model is described based on experimental vascular and intraperitoneal pressures, lymph flow, and peritoneal space compliance. The model's predictions accurately mimic clinical observations in ascites, including the magnitude and time course of changes observed following paracentesis or diuretic therapy.

show abstract

“…6,7) In addition, the elevated venous pressure resists the lymphatic inflow. 8,9) Blalock and Burwell have demonstrated the development of increased pressure and dilatation in the thoracic duct in their experiments on the hemodynamics of constrictive pericarditis. 10) It has been shown in animal studies that, in the presence of normal venous pressure, even when the thoracic duct is ligated, the development of chylous ascites is prevented by collaterals between the lymphatic and systemic circulations.…”

Section: A B Discussionmentioning

confidence: 99%

Chylous Ascites and Pleural Effusion Secondary to Constrictive Pericarditis Presenting With Signs of Lymphatic Obstruction

et al. 2004

View full text Add to dashboard Cite

SUMMARYChylous ascites is a clinical entity characterized by accumulation of milky fluid containing high amounts of triglycerides in the peritoneal cavity. The cause is usually lymphatic obstruction secondary to neoplastic processes. Constrictive pericarditis rarely causes cylous ascites through elevated venous pressure and lymphatic stasis. To the best of our knowledge, there is no report of constrictive pericarditis leading to chylous ascites in a patient presenting with objective lymphangiographic findings of lymphatic obstruction rather than stasis. We present a case of chylous ascites and pleural effusion secondary to constrictive pericarditis presenting with signs of lymphatic obstruction in lymphangiography, in whom complete clinical and laboratory improvement was achieved after pericardiectomy. (Jpn Heart J 2004; 45: 535-540)

show abstract

Effect of increased systemic venous pressure on lymph pressure and flow

Cited by 64 publications

References 0 publications

Lymph Flow Pattern in the Intact Thoracic Duct in Sheep

Lymph Flow Pattern in the Intact Thoracic Duct in Sheep

Quantitative modeling of the physiology of ascites in portal hypertension

Chylous Ascites and Pleural Effusion Secondary to Constrictive Pericarditis Presenting With Signs of Lymphatic Obstruction

Contact Info

Product

Resources

About