Effect of in vitro zinc supplementation on HSPs expression and Interleukin 10 production in heat treated peripheral blood mononuclear cells of transition Sahiwal and Karan Fries cows

Zinc supplementation prior to heat shock enhances HSP70 synthesis through HSF1 phosphorylation at serine 326 in human peripheral mononuclear cells

“…46 In line with the above-described data for tissue cells, oral zinc supplementation in healthy, but mildly zinc deficient elderly showed an increase in the ex vivo heat shock response of their isolated CD3 + and CD3 − cells. 31 In contrast, the addition of zinc decreased HSP70 induction during the heat shock response, as was detected for cow PBMC 19 and for Epstein Barr virus transformed human B cells from female donors, 30 both in vitro. Moreover, clear data on the effects of zinc deficiency on the heat shock-induced HSP70 expression by immune cells were not found.…”

“…17,18 However, reports of the role of zinc in heat shock protein activation are conflicting, as it has also been reported that zinc supplementation might decrease HSP70 levels following heat shock. 19 Many studies have reported that HSP70 protein expression can be induced by zinc alone 13,14,16 or zinc in combination with lipopolysaccharide (LPS) or through toxic drugs such as Acetaminophen, 18 but not by heat shock alone or in combination with zinc. Moreover, there is little research on zincinduced HSP70 expression in human blood cells, since most studies were performed using tissue cells and on animals.…”

The Impact of Trace Elements on Osteoarthritis

“…Zinc exerts anti-inflammatory effect through reducing the expression of proinflammatory cytokines, which can alleviate OA ( 145 ). Moreover, zinc supplementation significantly promotes the expression of interleukin-10 mRNA and blocks the expression of interleukin-1β mRNA and matrix metalloproteinases-13 protein, thereby massively raising serum interleukin-10 levels and reducing matrix metalloproteinases-13 and interleukin-1β levels ( 146 ). Interleukin-10 disturbs the secretion of proinflammatory cytokines and decreases the production of matrix metalloproteinases in chondrocytes ( 147 ).…”

Evaporative cooling in late gestation heat‐stressed Murrah buffaloes increases efficiency of next reproductive cycle

“…Environmental modifications have been performed in an attempt to alleviate heat stress in dairy cattle, for example, water spray and fans (Armstrong et al., ), evaporative cooling (Chaiyabutr, Chanpongsang, & Suadsong, ). The zinc supplementation in heat‐stressed lymphocytes ameliorates the adverse effects of thermal stress and modulates immunity in periparturient dairy cows in tropics (Sheikh, Aggarwal, & Aarif, ). Dry buffaloes under heat stress also experience reduced immune function and are at higher risk of diseases compared with buffaloes that are cooled when dry (do Amaral et al., ).…”