Effect of in utero growth retardation on lung function at follow-up of prematurely born infants

Abstract

Effect of in utero growth retardation on lung function at follow-up of prematurely born infants. A. Greenough, B. Yuksel, P. Cheeseman. #ERS Journals Ltd 2004. ABSTRACT: The aim of the study was to determine if prematurely born children who had suffered intra-uterine growth retardation (IUGR) had more severe lung function abnormalities than those born an appropriate weight for gestational age (AGA).Analysis of the lung function results of 119 infants (median (range) gestational age of 30 (23-35) weeks) was undertaken. In total, 31 of the infants had suffered IUGR and were born small for gestational age (SGA). Functional residual capacity and airways resistance (Raw) were measured at a median post-natal age of 10 (6-24) months. Specific airway conductance (sGaw) was calculated from thoracic gas volume and Raw.The SGA children were born at a greater gestational age and had a lower body weight at testing than the AGA children. Raw and sGaw differed between the SGA and AGA children. Regression analysis demonstrated that lung volumes were significantly related to body weight at testing, Raw was related to IUGR, maternal smoking and bronchopulmonary dysplasia, and sGaw to maternal smoking.In conclusion, these results suggest that prematurely born infants who have suffered intra-uterine growth retardation may be at increased risk of impaired lung function at follow-up. Eur Respir J 2004; 24: 731-733.

Respiratory function of very prematurely born infants at follow up: influence of sex

“…Adjustment for size at birth is important, as we 20 and others have shown that intrauterine growth retardation adversely effects infant lung function; in particular, airways resistance is significantly related to intrauterine growth retardation. Results of previous studies 3 21-26 are consistent with diminished airway function in male compared with female infants and children.…”

The effects of intrauterine growth restriction and antenatal glucocorticoids on ovine fetal lung development

“…Intrauterine growth restriction (IUGR) is a significant complication of pregnancy associated with increased risks of perinatal mortality and morbidity, including compromised lung development such as respiratory distress syndrome (7) and long-term impaired lung function in children (8) and adults (9). In experimental studies, structural changes in the IUGR fetal lung have been reported that may underlie impaired lung function.…”

Lung Function Tests in Neonates and Infants with Chronic Lung Disease of Infancy: Functional Residual Capacity

“…5 FRC pleth includes the volume of any gas trapped behind obstructed airways. Plethysmography has been used by numerous research groups since the 1960s, [6][7][8][9][10][11][12][13] and guidelinesfor standardizingequipment and techniqueswere publishedrecently. 5 Commerciallyproducedinfantplethysmographs that adhere to most of these specifications, and which have FDA and the Communauté Européene (CE) certificat, are now available.…”