Respiratory function of very prematurely born infants at follow up: influence of sex

Thomas, Mark R.

doi:10.1136/adc.2005.081927

Cited by 42 publications

(29 citation statements)

References 36 publications

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“…Our findings of boys with airway obstruction compared with girls are consistent with prior reports (27,(34)(35)(36), and the finding of black infants with increased airway obstruction compared with white infants also supports previous studies (37)(38)(39). The responsiveness to bronchodilators in our study (29% of infants) is comparable to that reported by Goldstein and colleagues (40), who found response to albuterol in 20 to 25% of a small cohort of healthy infants and young children born at more than 36 weeks of age, and to those of Debley and colleagues, who reported a bronchodilator response in 24% of 76 infants with recurrent wheezing (41).…”

Section: Original Researchsupporting

confidence: 82%

Pulmonary Morbidity in Infancy after Exposure to Chorioamnionitis in Late Preterm Infants

et al. 2016

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Rationale: Chorioamnionitis is an important cause of preterm birth, but its impact on postnatal outcomes is understudied.Objectives: To evaluate whether fetal exposure to inflammation is associated with adverse pulmonary outcomes at 6 to 12 months' chronological age in infants born moderate to late preterm. Methods:Infants born between 32 and 36 weeks' gestational age were prospectively recruited (N = 184). Chorioamnionitis was diagnosed by placenta and umbilical cord histology. Select cytokines were measured in samples of cord blood. Validated pulmonary questionnaires were administered (n = 184), and infant pulmonary function testing was performed (n = 69) between 6 and 12 months' chronological age by the raised volume rapid thoracoabdominal compression technique. Measurements and Main Results:A total of 25% of participants had chorioamnionitis. Although infant pulmonary function testing variables were lower in infants born preterm compared with historical normative data for term infants, there were no differences between infants with chorioamnionitis (n = 20) and those without (n = 49). Boys and black infants had lower infant pulmonary function testing measurements than girls and white infants, respectively. Chorioamnionitis exposure was associated independently with wheeze (odds ratio [OR], 2.08) and respiratory-related physician visits (OR, 3.18) in the first year of life. Infants exposed to severe chorioamnionitis had increased levels of cord blood IL-6 and greater pulmonary morbidity at age 6 to 12 months than those exposed to mild chorioamnionitis. Elevated IL-6 was associated with significantly more respiratory problems (OR, 3.23).Conclusions: In infants born moderate or late preterm, elevated cord blood IL-6 and exposure to histologically identified chorioamnionitis was associated with respiratory morbidity during infancy without significant changes in infant pulmonary function testing measurements. Black compared with white and boy compared with girl infants had lower infant pulmonary function testing measurements and worse pulmonary outcomes.

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Section: Original Researchsupporting

confidence: 82%

Pulmonary Morbidity in Infancy after Exposure to Chorioamnionitis in Late Preterm Infants

et al. 2016

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“…Male sex is considered an independent predictor for the development of BPD (Kraybill et al, 1989). The lung function in boys both in the neonatal period and at 1 year of age was noted to be worse when compared to girls (Stocks et al, 1997; Thomas et al, 2006). The reasons behind this are not known though better antioxidant defense mechanism in girls is thought to contribute to this advantage (Vento et al, 2009a; Hamon et al, 2011).…”

Section: Introductionmentioning

confidence: 91%

Sex-specific differences in hyperoxic lung injury in mice: Implications for acute and chronic lung disease in humans

Lingappan

Jiang

Wang

et al. 2013

Toxicology and Applied Pharmacology

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Sex-specific differences in pulmonary morbidity in humans are well documented. Hyperoxia contributes to lung injury in experimental animals and humans. The mechanisms responsible for sex differences in the susceptibility towards hyperoxic lung injury remain largely unknown. In this investigation, we tested the hypothesis that mice will display sex-specific differences in hyperoxic lung injury. Eight week-old male and female mice (C57BL/6J) were exposed to 72 h of hyperoxia (FiO2>0.95). After exposure to hyperoxia, lung injury, levels of 8-iso-prostaglandin F2 alpha (8-iso-PGF 2α) (LC-MS/MS), apoptosis (TUNEL) and inflammatory markers (suspension bead array) were determined. CytochromeP450 (CYP)1A expression in the lung was assessed using immunohistochemistry and western blotting. After exposure to hyperoxia, males showed greater lung injury, neutrophil infiltration and apoptosis, compared to air-breathing controls than females. Pulmonary 8-iso-PGF 2α levels were higher in males than females after hyperoxia exposure. Sexually dimorphic increases in levels of IL-6 (F>M) and VEGF (M>F) in the lungs were also observed. CYP1A1 expression in the lung was higher in female mice compared to males under hyperoxic conditions. Overall, our results support the hypothesis that male mice are more susceptible than females to hyperoxic lung injury and that differences in inflammatory and oxidative stress markers contribute to these sex-specific dimorphic effects. In conclusion, this paper describes the establishment of an animal model that shows sex differences in hyperoxic lung injury in a temporal manner and thus has important implications for lung diseases mediated by hyperoxia in humans.

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“…Male infants require more doses of surfactant, significantly longer mechanical support, and a greater proportion are oxygen dependent at 36 wk postmenstrual age (40). Findings such as these suggest that there may be sex differences in factors other than pulmonary surfactant that could contribute to the "male disadvantage."…”

mentioning

confidence: 94%

“…IT IS NOW WIDELY RECOGNIZED THAT, following preterm birth, males have a greater risk of death and illness compared with females (14,39,40,52), although the difference in mortality between males and females has declined in recent years (6,13).…”

mentioning

confidence: 97%

Sex differences in cardiorespiratory transition and surfactant composition following preterm birth in sheep

Ishak

Hanita

Sozo

et al. 2012

American Journal of Physiology-Regulatory, Integrative and Comp

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Male preterm infants are at greater risk of respiratory morbidity and mortality than females but mechanisms are poorly understood. Our objective was to identify the basis for the "male disadvantage" following preterm birth using an ovine model of preterm birth in which survival of females is greater than males. At 0.85 of term, fetal sheep underwent surgery (11 female, 10 male) for the implantation of vascular catheters to monitor blood gases and arterial pressure. After cesarean delivery at 0.90 of term, lambs were monitored for 4 h while spontaneously breathing; lambs were then euthanized and static lung compliance measured. We analyzed surfactant phospholipid composition in amniotic fluid and in bronchoalveolar lavage fluid (BALF) taken at necropsy; we also analyzed surfactant protein (SP) expression in lung tissue. Before delivery male fetuses tended to have lower pH (P = 0.052) compared with females. One hour after delivery, males had significantly lower pH and higher arterial partial pressure of CO(2) (Pa(CO(2))), lactate, glucose, and mean arterial pressure than females. Two males died 1 h after birth. Static lung compliance was 37% lower in males than females (P < 0.05). In BALF, males had significantly more protein, a lower percentage of the phosphatidylcholine (PC) 32:0 (dipalmitoylphosphatidylcholine) and higher percentages of PC34:2 and PC36:2. There were no sex-related differences in lung architecture or expression of SP-A, -B, -C, and -D. The lower lung compliance in male preterm lambs compared with females may be due to altered surfactant phospholipid composition and function. These changes may compromise gas exchange and impair respiratory adaptation after male preterm birth.

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Respiratory function of very prematurely born infants at follow up: influence of sex

Cited by 42 publications

References 36 publications

Pulmonary Morbidity in Infancy after Exposure to Chorioamnionitis in Late Preterm Infants

Pulmonary Morbidity in Infancy after Exposure to Chorioamnionitis in Late Preterm Infants

Sex-specific differences in hyperoxic lung injury in mice: Implications for acute and chronic lung disease in humans

Sex differences in cardiorespiratory transition and surfactant composition following preterm birth in sheep

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